Positive outcome in a high-grade myxofibrosarcoma: a case report

Open access


Myxofibrosarcoma or myxoid malignant fibrous histiocytoma is one of the most common sarcomas of the limb. It is usually treated multimodally. Most frequent sites of metastasis are the bone, lung and lymph nodes. The present paper is a case report of a 65-year-old male with myxofibrosarcoma of the fibularis longus muscle, for which he first underwent surgery - tumor resection with appropriate margins. The tumor was staged pT2b cN0 cM0. Postoperative PET-CT revealed metabolically inactive pulmonary nodules. Two months after surgery, he underwent adjuvant radiotherapy, a total dose of 60 Gy and 6 courses of chemotherapy (doxorubicin and ifosfamide). Pulmonary nodules have been stationary on all subsequent imagistic studies. He is free of recurrence on long-term follow-up.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. DeVita VT Lawrence TS Rosenberg SA. DeVita Hellman and Rosenberg’s cancer: Principles & practice of oncology. 10th ed. 2014 United States: Lippincott Williams and Wilkins 1540.

  • 2. Mentzel T van den Berg E Molenaar W. Myxofibrosarcoma. In: Fletcher C Unni K Mertens F. WHO classification of tumors - pathology and genetics tumors of soft tissue and bone. 2002 Lyon: IARC Press 102-1031.

  • 3. Castro BAC Piancastelli ACC Meyer RLB Piancastelli PM Ribeiro CA Miranda RMC. Myxofibrosarcoma - Case report. 2016; 91(1):97-9.

  • 4. Dodd LG Bui MM. Atlas of Soft Tissue and Bone Pathology: With Histologic Cytologic and Radiologic Correlations. 2015 New York: Demos Medical 68-71.

  • 5. Schepper AM Vanhoenacker F Gielen J Parizel PM. Imaging of soft tissue tumors. 3. 2006 Berlin Heidelberg New York: Springer-Verlag 196-198.

  • 6. Mentzel T Calonje E Wadden C Camplejohn RS Beham A Smith MA Fletcher CD. Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant. Am J SurgPathol. 1996; 20:391-405.

  • 7. Merck C Angervall L Kindblom LG Oden A. Myxofibrosarcoma. A malignant soft tissue tumor of fibroblastichistiocytic origin. A clinicopathologic and prognostic study of 110 cases using multivariate analysis. Acta PatholMicrobiol Immunol Scand. 1953; Suppl 282:1-40.

  • 8. Weiss SW Enzinger FM. Myxoid variant of malignant fibrous histiocytoma. Cancer. 1977; 39:1672-1685.

  • 9. Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Sarcoma Meta-analysis Collaboration. Lancet. 1997; 350:1647–54.

  • 10. Enneking WF Spanier SS Goodman MA. A system for the surgical staging of musculoskeletal sarcoma. ClinOrthopRelat Res. 1980; 153:106-120.

  • 11. Smolle MA Dimosthenis A Per-Ulf T Szkandera J Liegl-Atzwanger B Leithner A. Diagnosis and treatment of soft-tissue sarcomas of the extremities and trunk. EFORT Open Rev. 2017; 2:421-431.

  • 12. The ESMO/ European Sarcoma Network Working Group. Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis treatment and follow-up. Ann Oncol. 2014; 25:iii102-iii112.

  • 13. Judson I Verweij J Gelderblom H et al. European Organisation and Treatment of Cancer Soft Tissue and Bone Sarcoma GroupDoxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue sarcoma: a randomised controlled phase 3 trial. Lancet Oncol. 2014; 15:415-423.

  • 14. Antman K Crowley J Balcerzak SP et al. An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas. J ClinOncol. 1993; 11:1276-1285.

Journal information
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 305 184 3
PDF Downloads 291 230 0