Pain in the cervico-facial pathology: elements of etiopathogenesis, diagnosis and therapeutic principles

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The authors conduct a review of the etiopathogenesis, the main diagnostic methods and the treatment principles in cervico-facial pain. Pain in otorhinolaryngology is a multifactorial symptom, based on the rich innervation and vascularisation of the cephalic extremity. Pain can be of central or peripheral origin, acute and chronic. With the diversification of methods for exploring pain-generating lesions, different treatment protocols could also be achieved.

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  • 1. Bose CJ Capobianco DJ Cutrer FJ Cutrer FJ Dodick DW Garza I et al. Headache and other craniofacial pain. In: Bradley WG Daroff RB Fenichel GM Jankovic J (eds). Neurology in clinical practice. Volume 2. Fifth Edition. Butterworth-Heinemann Munich; 2008 p. 2011–62.

  • 2. International Headache Society. Headache Classification Subcommittee of the International Headache Society. The international classification of headache disorders. 2nd Edition. Cephalalgia. 2004;24(Suppl 1):9–160.

  • 3. Silberstein SD Olesen J Bousser MG Diener HC Dodick D First M et al. The international classification of headache disorders 2nd Edition (ICHD-II)–revision of criteria for 8.2 Medication-overuse headache. Cephalalgia. 2005;25(6):460–5.

  • 4. Enache R Sarafoleanu D. Pain in otorhinolaryngology. Rom J Rhinol. 2013;3(10):103-16.

  • 5. Tran Ba Huy P Manach Y. Les urgencies en ORL. Societe Fracaise d’ORL et de Chirurgie de la Face et de Cou. Paris; 2002 p.431-49.

  • 6. Cady RK Schreiber CP. Sinus headache: a clinical conundrum. Otolaryngol Clin North Am. 2004;37(2):267–88.

  • 7. Krams B Echenne B Leydet J Rivier F Roubertie A. Benign paroxysmal vertigo of childhood: long-term outcome. Cephalalgia. 2011;31(4):439–43. DOI: 10.1177/0333102410382797. Epub 2010 Sep 17.

  • 8. Oshinsky ML. Headache pathogenesis. In: Silberstein SD. (ed) Neurology and clinical neuroscience. 1st Edition. Mosby St Louis; 2007 p. 734-8.

  • 9. Sarafoleanu C. Sindroamele algice de origine rino-sinusala. In: Sarafoleanu C. (sub redactia) Rinologie. Editura Medicala Bucuresti; 2003 p.567-82.

  • 10. Paulson EP Graham SM. Neurologic diagnosis and treatment in patients with computed tomography and nasal endoscopy negative facial pain. Laryngoscope. 2004;114(11):1992–6.

  • 11. Stein C Clark JD Oh U Vasko MR Wilcox GL Overland AC et al. Peripheral mechanism of pain and analgesia. Brain Res Rev. 2009;60(1):90-113. DOI: 10.1016/j.brainresrev.2008.12.017. Epub 2008 Dec 31.

  • 12. Jarvis MF Boyce-Rustay JM. Neuropathic pain: models and mechanisms. Curr Pharm Des. 2009;15(15):1711-6.

  • 13. Lebovitz A. The psychological assessment of pain in patients with chronic pain. In: Wilson PR Watson P Haythornwaite J Jensen TS eds. Clinical Pain Management: Chronic Pain. 2nd Edition. London: Hodder and Stoughton Ltd; 2008 p. 122-31.

  • 14. Dodick DW Rozen TD Goadsby PJ Silberstein SD. Cluster headache. Cephalalgia. 2000;20(9):787–803.

  • 15. Altura BM Altura BT Gebrewold A. Alcohol induced spasm of cerebral blood vessels: relation to cerebrovascular accidents and sudden death. Science. 1983;220(4594):331-3.

  • 16. Ashina M. Tension-type headache. In: Silberstein SD. (ed) Neurology and clinical neuroscience. 1st Edition. Mosby; 2008 p. 757-61.

  • 17. Devor M Amir R Rappaport ZH. Pathophysiology of trigeminal neuralgia: the ignition hypothesis. Clin J Pain. 2002;18(1):4-13.

  • 18. Kondev L Minster A. Headache and facial pain in children and adolescents. Otolaryngol Clin North Am. 2003;36(6):1153-70.

  • 19. Baier B Winkenwerder E Dieterich M. “Vestibular migraine”: effects of prophylactic therapy with various drugs. A retrospective study. J Neurol. 2009;256(3):436–42. DOI: 10.1007/s00415-009-0111-3. Epub 2009 Mar 6.

  • 20. Tepper SJ Rapoport A Sheftell F. The pathophysiology of migraine. Neurologist. 2001;7(5):279-86.

  • 21. Schreiber CP Hutchinson S Webster CJ Ames M Richardson MS Powers C. Prevalence of migraine in patients with a history of self-reported or physician-diagnosed “sinus” headache. Arch Intern Med. 2004;164(16):1769–72.

  • 22. Lempert T Neuhauser H. Migrainous vertigo. Neurol Clin. 2005;23(3):715–30 vi.

  • 23. Rozen TD. Trigeminal autonomic cephalalgias. Neurol Clin. 2009;27(2):537–56. DOI: 10.1016/j.ncl.2008.11.005.

  • 24. Prasad S Galetta S. Trigeminal neuralgia: historical notes and current concepts. Neurologist. 2009;15(2):87–94. DOI: 10.1097/NRL.0b013e3181775ac3.

  • 25. Scher AI Stewart WF Lipton RB. Migraine and headache: a meta-analytic approach. In: Crombie IK Croft PR Linton SJ Leresche L Von Korff M. (eds) Epidemiology of pain. IASP Press Seattle; 1999 p. 159–70.

  • 26. Magis D Schoenen J. Treatment of migraine: update on new therapies. Curr Opin Neurol. 2011;24(3):203–10. DOI: 10.1097/WCO.0b013e3283462c3f.

  • 27. Kari E DelGaudio JM. Treatment of sinus headache as migraine: the diagnostic utility of triptans. Laryngoscope. 2008;118(12):2235–9. DOI: 10.1097/MLG.0b013e318182f81d.

  • 28. Thurel C Serrie A Cunin G Tran Ba Huy P. Traitement des douleurs irreductibles des cancers de la sphere ORL. Rev Prat. 1989;4;294-8.

  • 29. Cruccu G Gronseth G Alksne J Argoff C Brainin M Burchiel K Nurmikko T et al. AAN-EFNS guidelines on trigeminal neuralgia management. Eur J Neurol. 2008;15(10):1013–28. DOI: 10.1111/j.1468-1331.2008.02185.x. Epub 2008 Aug 21.

  • 30. Xie Z. 51 cases of occipital neuralgia treated with acupuncture. J Tradit Chin Med. 1992;12(3):180-1.

  • 31. Gronseth G Cruccu G Alksne J Argoff C Brainin M Burchiel K et al. Practice parameter: the diagnostic evaluation and treatment of trigeminal neuralgia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the European Federation of Neurological Societies. Neurology. 2008;71(15):1183–90. DOI: 10.1212/01.wnl.0000326598.83183.04. Epub 2008 Aug 20.

  • 32. Katusic S Williams DB Beard CM Bergstralh E Kurland LT. Incidence and clinical features of glossopharyngeal neuralgia Rochester Minnesota 1945-1984. Neuroepidemiology. 1991;10(5-6):266-75.

  • 33. Braun ES Schwedt JA Swarm TJ Hocking RA. Pain management in the head and neck patient. In: Flint PW Haughey BH Lund VJ Niparko JK Richardson MA Robbins KT et al (eds) Cummings Otolaryngology Head & Neck Surgery. Volume 1. 5th Edtion. Mosby/Elsevier; 2010 p. 239–49.

  • 34. Graff-Radford SB Newman A Ananda A. Treatment options for glossopharyngeal neuralgia. Therapy. 2005;2(5):733-7. DOI: 10.1586/14750708.2.5.733.

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