Invasive fungal rhinosinusitis

Lucia Gariuc 1 , Alexandru Sandul 1 , and Lupoi Daniel 2
  • 1 Otorhinolaryngology Department, “Nicolae Testemitanu” State University of Medicine and Pharmacy, Chisinau
  • 2 ENT&HNS Department, “Sfanta Maria” Hospital, Bucharest, Romania


Invasive fungal rhinosinusitides are a group of disorders with three subtypes (acute invasive fungal rhinosinusitis, chronic invasive fungal rhinosinusitis and granulomatous invasive fungal rhinosinusitis), requiring urgent diagnosis and early treatment due to the reserved vital and functional prognosis. This disorder occurs in immunocompromised patients, but it can also occur in immunocompetent people. Aspergillus and Mucormicosis species are the most common microorganisms found in invasive fungal rhinosinusites. The otorhinolaryngologic clinical examination and imaging techniques provide important diagnostic information in patients with risk factors for invasive fungal rhinosinusitis, including intracranial or orbital extension identification. The treatment of invasive fungal rhinosinusites (acute or chronic) consists of reversing immunosuppression, appropriate systemic antifungal therapy and aggressive and prompt surgical debridement of the affected tissues.

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