Small cell neuroendocrine carcinoma: A rare second primary malignancy after treatment of nasopharyngeal carcinoma

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Small cell neuroendocrine carcinoma (SCNEC) of the nasopharynx and nasal cavity is a rare condition. It is an aggressive malignancy with a high recurrence rate. Despite its rarity in the sinonasal region, it may occur as a second primary malignancy. Patients with cancer of the head and neck region are more prone to develop a second primary tumor due to the field cancerization phenomenon, and a higher incidence is seen in those who have previously received radiation therapy. A detailed clinical and histopathological examination is pivotal to diagnose SCNEC as a second primary malignancy. We wish to highlight such a peculiar case from our center.

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  • 1. Chen CL Hsu MM. Second primary epithelial malignancy of nasopharynx and nasal cavity after successful curative radiation therapy of nasopharyngeal carcinoma. Hum Pathol. 2000;31(2):227-32.

  • 2. Bellahammou K Lakhdissi A Akkar O Kouhen F Rais F Dahraoui S et al. Small-cell neuroendocrine carcinoma of nasopharynx: a case report. IJSM. 2017;3(2):132-5.

  • 3. Aguiar A Jacome M Azevedo I Monteiro E Castro V. Small-cell neuroendocrine carcinoma originating from the nasopharynx: report of a rare case. Rep Radiother Oncol. 2015;2(3):e3814. DOI: 10.17795/rro-3814.

  • 4. Nagy AA Trombitas V Vlad D Albu S. Sinonasal neuroendocrine carcinoma – a case report. Romanian Journal of Rhinology. 2014;4(14):117-20.

  • 5. Radhakrishnan D Supriya NK Varma KR. Sinonasal neuroendocrine carcinoma in a young female - a case report. Journal of Clinical and Diagnostic Research. 2017;11(11):ED05-ED06. Available from:

  • 6. Montone KT. The differential diagnosis of sinonasal/nasopharyngeal neuroendocrine/neuroectodermally derived tumors. Arch Pathol Lab Med. 2015;139(12):1498-507. DOI: 10.5858/arpa.2014-0383-RA.

  • 7. Azevedo D Rios E Vendeira L Sarmento C. Small cell neuroendocrine carcinoma of the nasopharynx: a rare case report. Autops Case Rep. 2017;7(1):31-5. DOI: 10.4322/acr.2017.002.

  • 8. Lin CH Chiang TP Shum WY Hsu CH Tsai YC Tsao TY et al. Primary small cell neuroendocrine carcinoma of the nasal cavity after successful curative therapy of nasopharyngeal carcinoma: a case report. Kaohsiung J Med Sci. 2009;25(3):145-50.

  • 9. Shah K Perez-Ordóñez B. Neuroendocrine neoplasms of the sinonasal tract: neuroendocrine carcinomas and olfactory neuroblastoma. Head Neck Pathol. 2016;10(1):85-94. DOI: 10.1007/s12105-016-0696-7. Epub 2016 Feb 1.

  • 10. Silva EG Butler JJ MacKay B Goepfert H. Neuroblastomas and neuroendocrine carcinomas of the nasal cavity. A proposed new classification. Cancer. 1982;50(11):2388-405.

  • 11. Rosenthal DI Barker JL El-Naggar AK Glisson BS Kies MS Diaz EM et al. Sinonasal malignancies with neuroendocrine differentiation: patterns of failure according to histologic phenotype. Cancer. 2004;101(11):2567-73.

  • 12. Guo C Pan Q Su M Li R. Clinical immunophenotype of nasopharyngeal neuroendocrine carcinoma with metastatic liver cancer. Clin Chim Acta. 2017;471:283-5. DOI: 10.1016/j.cca.2017.06.016. Epub 2017 Jun 17.

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