The impact of gastroesophageal reflux in the ENT pathology

Abstract

Frequently encountered in medical practice, the gastroesophageal reflux (GER) is a chronic condition characterized by the passage of gastric acid or gastric contents into the esophagus. In otorhinolaryngology, the diagnosis of pharyngo-laryngeal or rhinosinusal inflammatory conditions secondary to GER is one of exclusion and it is based on a detailed anamnesis in which we are interested in symptoms, behavioural and medical risk factors, on the ENT clinical examination, the laryngo-fibroscopical assessment, the phoniatric examination, the barite pharyngo-esogastric exam, the upper gastrointestinal endoscopy and the esophageal manometry.

The authors are making a systematization of the contribution of the gastroesophageal reflux has in the ENT pathology, emphasising the sympytoms and the most frequent associated pathological entities.

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  • 1. Vakil N., van Zanten S.V., Kahrilas P., Dent J., Jones R.; Global Consensus Group. - The Montreal definition and classification of gastroesophageal reflux disease. Am J Gastroenterol., 2006;101(8):1900-1920.

  • 2. Barnhart D.C. - Gastroesophageal reflux disease in children. Seminars In Pediatric Surgery. http://dx.doi.org/10.1053/j.sempedsurg.2016.05.009.

  • 3. El-Serag H.B. - Time trends of gastroesophageal reflux disease: a systematic review. Clin Gastroenterol Hepatol., 2007;5(1):17-26. Epub 2006 Dec 4.

  • 4. Patti MG. - Gastroesophageal reflux disease. Available at: emedicine.medscape. com/article/176595-overview.

  • 5. Rival R., Wong R., Mendelsohn M., Rosgen S., Goldberg M., Freeman J. - Role of gastroesophageal reflux disease in patients with cervical symptoms. Otolaringol Head Neck Surg., 1995;113(4):364-369.

  • 6. Koufman J.A., Amin M.R., Panetti M. - Prevalene of reflux in 113 consecutive patients with laryngeal and voice disorders. Otolaringol Head Neck Surg., 2000;123(4):385-388.

  • 7. Ho K.Y., Kang J.Y., Seow A. - Prevalence of gastrointestinal symptoms in a multiracial Asian population, with particular reference to reflux-type symptoms. Am J Gastroenterol., 1998;93(10):1816-1822.

  • 8. Ruigomez A., Garcia Rodriguez L.A., Wallander M.A., Johansson S., Graffner H., Dent J. - Natural history of gastro-oesophageal reflux disease diagnosed in general practice. Aliment Pharmacol Ther., 2004;20(7):751-760.

  • 9. Lagergren J., Bergstrom R., Lindgren A., Nyrén O. - Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med., 1999;340(11):825-831.

  • 10. Vaezi M.F. - Sensitivity and specificity of reflux-attributed laryngeal lesions: experimental and clinical evidence. Am J Med., 2003;115 Suppl 3A:97S-104S.

  • 11. Richter J.E. - Extraesophageal presentations of gastroesophageal reflux disease. Semin Gastrointest Dis., 1997;8(2):75-89.

  • 12. Wong R.K., Hanson D.G., Waring P.J., Shaw G. - ENT manifestations of of gastroesophageal reflux. Am J Gastroenterol., 2000;95(8 Suppl):S15-S22.

  • 13. Vaezi M.F. - Laryngeal manifestations of gastroesophageal reflux disease. Curr Gastroenterol Rep., 2008;10(3):271-277.

  • 14. Carr M.M., Nagy M.L., Pizzuto M.P., Poje C.P., Brodsky L.S. - Correlation of findings at direct laryngoscopy and bronchoscopy with gastroesophageal reflux disease in children: a prospective study. Arch Otolaryngol Head Neck Surg., 2001;127(4):369-374.

  • 15. Hanson D.G., Jiang J.J. - Diagnosis and management of chronic laryngitis associated with reflux. Am J Med., 2000;108 Suppl 4a:112S-119S.

  • 16. Habermann W., Eherer A., Lindbichler F., Raith J., Friedrich G. - Ex juvantibus approach for chronic posterior laryngitis: results of short-term pantoprazole therapy. J Laryngol Otol., 1999;113(8):734-739.

  • 17. Havas T.E., Priestley J., Lowinger D.S. - A management strategy for vocal process granuloma. Laryngoscope, 1999;109(2 Pt 1):301-306.

  • 18. Hoffman H.T., Overholt E., Karnell M., McCulloch T.M. - Vocal process granuloma. Head Neck, 2001;23(12):1061-1074.

  • 19. Chan G., Boyle J.O., Yang E.K., Zhang F., Sacks P.G., Shah J.P., Edelstein D., Soslow R.A., Koki A.T., Woerner B.M., Masferrer J.L., Dannenberg A.J. - Cyclooxygenase-2 Expression Is Up-Regulated in Squamous Cell Carcinoma of the Head and Neck. Cancer Res., 1999;59(5):991-994.

  • 20. Galli J., Cammarota G., Calò L., Agostino S., D'Ugo D., Cianci R., Almadori G. - The role of acid and alkaline reflux in laryngeal squamous cell carcinoma. Laryngoscope, 2002;112(10):1861-1865.

  • 21. Lewin J.S., Gillenwater A.M., Garrett J.D., Bishop-Leine J.K., Nguyen D.D., Callender D.L., Ayers G.D., Myers J.N. - Characterization of laryngpharyngeal reflux in patients with premalignant or early carcinoma of the larynx. Cancer, 2003;97(4):1010-1014.

  • 22. Samuelson C.F. - Gastroesophageal reflux and obstructive sleep apnea. Sleep, 1989;5:475-476.

  • 23. Kerr P., Shoenut J.P., Millar T., Buckle P., Kryger M.H. - Nasal CPAP reduces gastroesophageal reflux in obstructive sleep apnea syndrome. Chest, 1992;101(6):1539-1544.

  • 24. Graf K.I., Karaus M., Heinemann S., Korber S., Dorow P., Hampel K.E. - Gastroesophageal reflux in patients with sleep apnea syndrome. Z Gastroenterol., 1995;33(12):689-693.

  • 25. Ing A.J., Ngu M.C., Breslin A.B. - Obstructive sleep apnea and gastroesophageal reflux. Am J Med., 2000;108 Suppl 4a:120S-125S.

  • 26. Locke G.R. 3rd, Talley N.J., Fett S.L., Zinsmeister A.R., Melton L.J. 3rd - Prevalence and clinical spectrum of gastroesophageal reflux: a population- based study in Olmsted County, Minnesota. Gastroenterology, 1997;112(5):1448-1456.

  • 27. Valipour A., Makker H.K., Hard R., Emegbo S., Toma T., Spiro S.G. - Symptomatic gastroesophageal reflux in subjects with a breathing sleep disorder. Chest, 2002;121(6):1748-1753.

  • 28. Jecker P., Orloff L.A., Wohlfeil M., Mann W.J. - Gastroesophageal reflux disease (GERD), extraesophageal reflux (EER) and recurrent chronic rhinosinusitis. Eur Arch Otorhinolaryngol., 2006;263(7):664-667. Epub 2006 Mar 9.

  • 29. Delehaye E., Dore M.P., Bozzo C., Mameli L., Delitala G., Meloni F. - Correlation between nasal mucociliary clearance time and gastroesophageal reflux disease: our experience on 50 patients. Auris Nasus Larynx, 2009;36(2):157-161. doi: 10.1016/j.anl.2008.06.004. Epub 2008 Sep 5.

  • 30. Katle E.J., Hart H., Kjaergaard T., Kvaloy J.T., Steinsvag S.K. - Nose- and sinus-related quality of life and GERD. Eur Arch Otorhinolaryngol., 2012;269(1):121-125. doi: 10.1007/s00405-011-1675-y. Epub 2011 Jun 26.

  • 31. Temnikova I.V., Onuchina E.V., Subbotina M.V., Kozlova N.A. - Especially chronic rhinosinusitis associated with gastroesophageal reflux disease. Eksp Klin Gastroenterol., 2015;(3):21-25.

  • 32. Dibaise J.K., Sharma V.K. - Does gastroesophageal reflux contribute to the development of chronic sinusitis? A review of the evidence. Dis Esophagus., 2006;19(6):419-424.

  • 33. Roesch-Ramos L., Roesch-Dietlen F., Remes-Troche J.M., Romero-Sierra G., Mata-Tovar Cde J., Azamar-Jacome A.A., Barranca-Enríquez A. - Dental erosion, an extraesophageal manifestation of gastroesophageal reflux disease. The experience of a center for digestive physiology in Southeastern Mexico. Rev Esp Enferm Dig., 2014;106(2):92-97.

  • 34. Phipps C.D., Wood W.E., Gibson W.S., Cochran W.J. - Gastroesophageal reflux contributing to chronic sinus disease in children. Arch Otolaryngol Head Neck Surg., 2000;126(7):831-836.

  • 35. Sylvester D.C., Karkos P.D., Vaughan C., Johnston J., Dwivedi R.C., Atkinson H., Kortequee S. - Chronic Cough, Reflux, Postnasal Drip Syndrome, and the Otolaryngologist. International Journal of Otolaryngology, 2012;vol. 2012, Article ID 564852, 5 pages

  • 36. doi:10.1155/2012/564852.

  • 37. De Benedetto M., Monaco G., Marra F. - Extra-laryngeal manifestations of gastro-oesophageal reflux. Acta Otorhinolaryngol Ital., 2006;26(5):256-259.

  • 38. Schwarz S.M. - Pediatric gastroesophageal reflux. Available at: http://emedicine.medscape.com/article/930029-overview#a5.

  • 39. Rudolph C.D. - Supraesophageal complications of gastroesophageal reflux in children: challenges in diagnosis and treatment. Am J Med., 2003;115 Suppl 3A:150S-156S.

  • 40. Weaver E.M. - Association between gastroesophageal reflux and sinusitis, otitis media and laryngeal malignancy: a systemic review of the evidence. Am J Med., 2003;115 Suppl 3A:81S-89S.

  • 41. Bouchard S., Lallier M., Yazbeck S., Bensoussan A. - The otolaryngologic manifestations of gastresophageal reflux: when is a pH study indicated? J Pediatr Surg., 1999;34(7):1053-1056.

  • 42. Caruso G., Passali F.M. - ENT manifestations of gastro-oesophageal reflux in children. Acta Otorhinolaryngol Ital., 2006;26(5):252-255.

  • 43. Tasker A., Dettmar P.W., Panetti M., Koufman J.A., Birchall J.P., Pearson J.P. - Reflux of gastric juice and glue ear in children. Lancet, 2002;359(9305):493.

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