Caplan’s Syndrome (rheumatoid pneumoconiosis), a rare disease entity: case report

Mircea-Constantin Diaconu 1 , Laura-Georgiana Moise 2 ,  and Agripina Rașcu 1 , 2
  • 1 Department of Occupational Medicine, Colentina Clinical Hospital, Bucharest, Romania
  • 2 Occupational Medicine Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania


Caplan’s syndrome, known as rheumatoid pneumoconiosis, was first described by Anthony Caplan in 1953, who identified a rare lung disorder found in coal mine workers with rheumatoid arthritis. Although Caplan’s syndrome was found in patients with a variety of pneumoconioses, it mostly affects individuals with long exposure to crystalline silica. We present a case of Caplan’s syndrome in a patient with advanced stage of rheumatoid arthritis and silicosis.

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  • 1. Alaya Z, Braham M, Aissa S, Kalboussi H, Bouajina E. A case of Caplan syndrome in a recently diagnosed patient with silicosis: A case report. Radiology case reports. 2018;13(3):663-6.

  • 2. Schreiber J, Koschel D, Kekow J, Waldburg N, Goette A, Merget R. Rheumatoid pneumoconiosis (Caplan’s syndrome). European Journal of Internal Medicine. 2010;21(3):168-72.

  • 3. De Capitani EM, Schweller M, Silva CM, Metze K, Cerqueira EM, Bértolo MB. Rheumatoid pneumoconiosis (Caplan’s syndrome) with a classical presentation. Jornal brasileiro de pneumologia: publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia. 2009.

  • 4. Kay J, Upchurch KS. ACR/EULAR 2010 rheumatoid arthritis classification criteria. Rheumatology. 2012;51(suppl_6):vi5-9.

  • 5. Tellesson WG. Rheumatoid pneumoconiosis (Caplan’s syndrome) in an asbestos worker. Thorax. 1961;16(4):372.

  • 6. Honma K, Vallyathan V. Rheumatoid pneumoconiosis: a comparative study of autopsy cases between Japan and North America. Annals of Occupational Hygiene. 2002;46(suppl_1):265-7.

  • 7. Alaya Z, Braham M, Aissa S, Kalboussi H, Bouajina E. A case of Caplan syndrome in a recently diagnosed patient with silicosis: A case report. Radiology case reports. 2018 Jun 1;13(3):663-6.

  • 8. Calvert GM, Rice FL, Boiano JM, Sheehy JW, Sanderson WT. Occupational silica exposure and risk of various diseases: an analysis using death certificates from 27 states of the United States. Occupational and environmental medicine. 2003;60(2):122-

  • 9. Otsuki T, Miura Y, Nishimura Y, Hyodoh F, Takata A, Kusaka M, Katsuyama H, Tomita M, Ueki A, Kishimoto T. Alterations of Fas and Fas-related molecules in patients with silicosis. Experimental Biology and Medicine.2006;231(5):522-33.

  • 10. Benvenuti Pernis: Silica and immune system. Acta Bio-Medica; Atenei Parmensis.2005;76 Suppl 2:38-44.

  • 11. Nemakayala DR, Ramphul K. Caplan Syndrome.

  • 12. Silicoza-Ghid de Practica Medicala, Revista Româna de Medicina Muncii. 2010;61(1-2):4-11.

  • 13. Przygodzka M, Filipowicz-Sosnowska A. Prevalence of thyroid diseases and antithyroid antibodies in women with rheumatoid arthritis. Pol Arch Med Wewn.2009;119:39–43.

  • 14. Emamifar A, Hangaard J, Hansen IM. Thyroid disorders in patients with newly diagnosed rheumatoid arthritis is associated with poor initial treatment response evaluated by disease activity score in 28 joints-C-reactive protein (DAS28-CRP): An observational cohort study. Medicine.2017;96(43).

  • 15. Castaneda S, Gonzalez-Juanatey C, Gonzalez-Gay MA. Inflammatory arthritis and heart disease. Current pharmaceutical design. 2018;24(3):262-80.


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