Prostate cancer: an occupational hazard in Romania?

Open access

Abstract

Several occupational carcinogens (arsenic, cadmium) and industries (rubber production) have been associated with prostate cancer risk but most of the data are from studies conducted on screened populations. Here we explored this association in Romanian men, a population with low PSA screening test coverage. We have analyzed 468 prostate cancer cases pathologically confirmed and 495 non-cancer hospital controls, recruited in the ROMCAN project. Personal information, including occupational activity, was collected through interview. Two experts classified jobs and activities into 15 economic sectors with similar patterns of exposure. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between ever employed in each economic sector and prostate cancer risk. We observed a higher non adjusted risk for employment in electricity, gas, steam and air conditioning supply activities (OR=3.95, p=0.029), manufacturing–light industry (OR=1.88, p=0.039), financial, insurance and gambling (OR=1.44, p=0.046) and a lower risk for employment in construction industry (OR=0.62, p=0.010). After adjusting for potential confounders, only the low risk in construction workers was maintained (OR=0.55, p=0.004). Our study provides some evidence on the role of occupational factors on the prostate cancer risk but further assessments are needed. Healthy lifestyle promotion and prevention should be reinforced at workplaces.

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  • 1. Ferlay J Colombet M Soerjomataram I Dyba T Randi G Bettio M Gavin A Visser O Bray F. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. European Journal of Cancer. 2018;103:356–87.

  • 2. Taitt H.E. Global Trends and Prostate Cancer: A Review of Incidence Detection and Mortality as Influenced by Race Ethnicity and Geographic Location. Am J Mens Health.2018;12:1807–23.

  • 3. Center MM Jemal A Lortet-Tieulent J Ward E Ferlay J Brawley O Bray F. International variation in prostate cancer incidence and mortality rates. Eur. Urol. 2012;61:1079–92.

  • 4. Sritharan J MacLeod J Harris S Cole DC Harris A Tjepkema M Peters PA Demers PA. Prostate cancer surveillance by occupation and industry: the Canadian Census Health and Environment Cohort (CanCHEC). Cancer Med. 2018;7:1468–78.

  • 5. Pukkala E Martinsen JI Lynge E Gunnarsdottir HK Sparén P Tryggvadottir L Weiderpass E Kjaerheim K. Occupation and cancer - follow-up of 15 million people in five Nordic countries. Acta Oncol. 2009;48:646–790.

  • 6. Gann PH. Risk Factors for Prostate Cancer. Rev Urol. 2002;4:S3–S10.

  • 7. LeMasters GK Genaidy AM Succop P Deddens J Sobeih T Barriera-Viruet H Dunning K Lockey J. Cancer risk among firefighters: a review and meta-analysis of 32 studies. J. Occup. Environ. Med. 2006;48:1189–1202.

  • 8. Rao D Yu H Bai Y Zheng X Xie L. Does night-shift work increase the risk of prostate cancer? a systematic review and meta-analysis. Onco Targets Ther. 2015;8:2817–26.

  • 9. Ragin C Davis-Reyes B Tadesse H Daniels D Bunker CH Jackson M Ferguson TS Patrick AL Tulloch-Reid MK Taioli E. Farming Reported Pesticide Use and Prostate Cancer. Am J Mens Health. 2013;7: 102–9.

  • 10. Kogevinas M Sala M Boffetta P Kazerouni N Kromhout H Hoar-Zahm S. Cancer risk in the rubber industry: a review of the recent epidemiological evidence. Occup Environ Med. 1998;55:1–12.

  • 11. van der Gulden JW. Metal workers and repairmen at risk for prostate cancer: a review. Prostate. 1997;30:107–16.

  • 12. Parent MÉ Désy M Siemiatycki J. Does Exposure to Agricultural Chemicals Increase the Risk of Prostate Cancer among Farmers? Mcgill J Med. 2009;12:70–7.

  • 13. Román MD Niclis C Aballay LR Lantieri MJ Díaz MDP Muñoz SE. Do Exposure to Arsenic Occupation and Diet Have Synergistic Effects on Prostate Cancer Risk? Asian Pac J Cancer Prev. 2018;19:1495–1501.

  • 14. Deng Y Wang M Tian T Lin S Xu P Zhou L Dai C Hao Q Wu Y Zhai Z. The Effect of Hexavalent Chromium on the Incidence and Mortality of Human Cancers: A Meta-Analysis Based on Published Epidemiological Cohort Studies. Front Oncol.2019:9.

  • 15. Benedetti M Zona A Beccaloni E Carere M Comba P. Incidence of Breast Prostate Testicular and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties. Int J Environ Res Public Health. 2017:14.

  • 16. Adler C.; Friesen M.C.; Yeboah E.D.; Tettey Y.; Biritwum R.B.; Adjei A.A.; Tay E.; Okyne V.; Mensah J.E.; Truelove A.; et al. Usual adult occupation and risk of prostate cancer in West African men: The Ghana Prostate Study. Occup Environ Med. 2019;76:71–7.

  • 17. Crişan N Feciche BO Porav Hodade D Mihaly Z Meteş O et al. Experienţa „Centrului de screening în cancerul de prostată” Cluj-Napoca în primul an de activitate. Revista Romana de Urologie. 2006:1.

  • 18. Iordache PD Mates D Gunnarsson B Eggertsson HP Sulem P. Guðmundsson J Benónísdóttir S Csiki IE Rascu S Radavoi D et al. Profile of common prostate cancer risk variants in an unscreened Romanian population. J Cell Mol Med. 2018;22:1574–82.

  • 19. Jinga V Csiki IE Manolescu A Iordache P Mates IN Radavoi D Rascu S Badescu D Badea P. Mates D. Replication study of 34 common SNPs associated with prostate cancer in the Romanian population. J Cell Mol Med. 2016;20:594–600.

  • 20. Iordache PD Mates D Gunnarsson B Eggertsson H.P Sulem P Benonisdottir S Csiki IE Rascu S Radavoi D Ursu R et al. Identification of Lynch syndrome risk variants in the Romanian population. J. Cell. Mol. Med. 2018 22 6068–6076.

  • 21. Loomis D Guha N Hall AL Straif K. Identifying occupational carcinogens: an update from the IARC Monographs. Occup Environ Med. 2018;75:593–603.

  • 22. Cogliano VJ Baan R Straif K Grosse Y Lauby-Secretan B El Ghissassi F Bouvard V Benbrahim-Tallaa L Guha N Freeman C et al. Preventable Exposures Associated With Human Cancers. J Natl Cancer Inst. 2011;103:1827–39.

  • 23. Krstev S Baris D Stewart PA Hayes RB Blair A Dosemeci M. Risk for prostate cancer by occupation and industry: a 24-state death certificate study. Am J Ind Med. 1998;34:413–20.

  • 24. Sauvé JF Lavoué J Parent MÉ. Occupation industry and the risk of prostate cancer: a case-control study in Montréal Canada. Environ Health. 2016:15.

  • 25. Lynch BM Friedenreich CM Kopciuk KA Hollenbeck AR Moore SC Matthews CE. Sedentary behavior and prostate cancer risk in the NIH-AARP Diet and Health Study. Cancer Epidemiol Biomarkers Prev. 2014;23:882–9.

  • 26. Stocks T Hergens MP Englund A Ye W Stattin P. Blood pressure body size and prostate cancer risk in the Swedish Construction Workers cohort. Int J Cancer 2010;127:1660–68.

  • 27. Keller JE Howe HL. Cancer in Illinois construction workers: A study. American Journal of Industrial Medicine. 1993;24:223–30.

  • 28. Peters CE Demers PA Kalia S Hystad P Villeneuve PJ Nicol AM Kreiger N Koehoorn MW. Occupational exposure to solar ultraviolet radiation and the risk of prostate cancer. Occup Environ Med. 2016; 73:742–8.

  • 29. Teschke K Olshan A Daniels J De Roos AJ Parks C Schulz M Vaughan T Kromhout H. Occupational exposure assessment in case–control studies: opportunities for improvement. Occup Environ Med. 2002;59:575–94.

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