Primary histiocytic sarcoma of the uterine cervix: an extremely rare entity

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Objective. Histiocytic sarcoma (HS) is an extraordinary rare tumor and it has an offensive clinical course. HS of the uterine cervix is a far uncommon tumor with just a few cases described so far. Here we presented a case of primary HS of the uterine cervix in a 62-year-old female initially misdiagnosed as large cell non-keratinizing squamous cell carcinoma. To the best of our knowledge, this is the first reported case of HS of the uterine cervix from Iran.

Case report. The patient presented with post-menopausal vaginal bleeding. Further evaluations revealed the presence of a relatively large cervical mass that was sampled. Under the preliminary diagnosis of large cell non-keratinizing squamous cell carcinoma, the patient underwent radical surgery. Postoperative pathological examination confirmed the diagnosis of HS of the uterine cervix. The patient received chemotherapy.

Conclusion. Clinical presentations of HS of the uterine cervix are very similar to more common cervical tumors; as a result its diagnosis relies on immunohistochemical methods. A correct diagnose could lead to the proper and timely treatment.

1. TAKAHASHI E, NAKAMURA S. Histiocytic sarcoma: an updated literature review based on the 2008 WHO classification. J Clin Exp Hematop. 2013; 53(1):1-8.

2. SWERDLOW SH, CAMPO E, HARRIS NL. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th edition. Lyon, France: IARC Press; 2008, 354-357.

3. JAFFE E S. Histiocytic and dendritic cell neoplasms. In: Jaffe E S, Harris N L, Stein, H et al. (eds), World Health Orgnization classification of tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press 2001: 275-277.

4. CHEN CJ, WILLIAMS EA, MCANENEY TE, et al. Histiocytic sarcoma of the cavernous sinus: case report and literature review, Brain Tumor Pathol 2015; 32:66-71.

5. MATHE G, GERARD-MARCHANT R, TEXIER JL, SCHLUMBERGER JR, BERUMEN L, PAINTRAND M. The two varieties of lymphoid tissue “reticulosarcomas”, histiocytic and histioblastic types. Br J Cancer, 1970; 24:687-695.

6. HORNICK JL, JAFFE ES, FLETCHER CD. Extranodal histiocytic sarcoma: Clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol2004; 28:1133-44.

7. VOS JA, ABBONDANZO SL, BAREKMAN CL, ANDRIKO JW, MIETTINEN M, AGUILERA NS. Histiocytic sarcoma: a study of five cases including the histiocyte marker CD163. Mod Pathol. 2005; 18(5):693-704.

8. WANG H, ZHANG J, TAO Q, et al. Flow cytometry used to identify histiocytic sarcoma: A case report. Cytometry B Clin Cytom. 2015, doi: 10.1002/cyto.b.21262. [Epub ahead of print]

9. SUN W, NORDBERG ML, FOWLER MR. Histiocytic sarcoma involving the central nervous system: clinical, immunohistochemical, and molecular genetic studies of a case with review of the literature. Am J Surg Pathol 2003; 27:258-265.

10. COPIE-BERGMAN C, WOTHERSPOON AC, NORTON AJ, DISS TC, ISAACSON PG. True histiocytic lymphoma. A morphologic immunohistochemical and molecular genetic study of 13 cases. Am J Surg Pathol 1998; 22:1386-92.

11. SWERDLOW SH, INTERNATIONAL AGENCY FOR REARCH ON CANCER. World Health Organization classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC; 2008.

12. DE VOS FY, GERDING MN, ARENDS JW, WEGMAN JJ. Histiocytic sarcoma localised in the thyroid: A case report. Ann Hematol 2008; 87:681-2.

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