Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer

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Abstract

Mast cells proteases, tryptase and chymase are directly involved in the growth and progression of solid tumors due to their important role in tumor angiogenesis. We examined the density of tryptase positive mast cells and the mean density of new blood vessels in gastric malignant tumors of patients with and without Helicobacter pylori infection, using immunohistochemical staining for tryptase (for mast cells) and CD 105 (for new vessels). Tryptase and CD 105 expression was detected in gastrectomy specimens. In this study, mast cell density correlates with angiogenesis and the growth and progression of gastric cancer. It also shows that the participation of Helicobacter pylori infection in the growth and progress of gastric neoplasia is due to an increase of peritumoral angiogenesis, with subsequent local and distant tumor spread and perivascular growth, but without perineural and nodal involvement.

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  • 1. YANG L. et al. Cancer stem cells biomarkers in gastric carcinogenesis. J. Gastrointestin Canc. 2013; 44:428-435.

  • 2. LAZĂR D. et al. Tumor angiogenesis in gastric cancer. Rom. J. Morphol. Embryol. 2006; 47:5-13.

  • 3. RIBATTI D. et al. Mast cells and angiogenesis in gastric carcinoma. Int. J. Exp. Pathol. 2010; 91:350-356.

  • 4. AMMENDOLA M. Infiltrating mast cells correlate with angiogenesis in bone metastases from gastric cancer patients. Int. J. Mol. Sci. 2015; 16:3237-3250.

  • 5. YU JX ZHANG XT LIAO YQ ZHANG QY CHEN H LIN M KUMAR S. Relationship between expression of CD105 and growth factors in malignant tumors of gastrointestinal tract and its significance. World J Gastroenterol. 2003; 9(12):2866-2869.

  • 6. BODEY B BODEY B JR SIEGEL SE KAISER HE. Over-expression of endoglin (CD105): a marker of breast carcinomainduced neo vascularization. Anticancer Res 1998; 18:3621-3628.

  • 7. DALLAS NA et al. Endoglin (CD105): a marker of tumor vasculature and potential target for therapy. Clin. Cancer Res. 2008; 14 (7):1931-1937.

  • 8. CH’NG S. et al. Mast cells and cutaneous malignancies. Modern Pathology. 2006; 1(1):149-159.

  • 9. DE SOUZA DA JR. The role of mast cell specific chymase and tryptase in tumor angiogenesis. 2015; 2015: Article ID 142359 13 pages.

  • 10. HASSAN S. et al. Expression of protooncogene c-kit and its ligand stem cell factor (SCF) in gastric carcinoma cell lines. Dig. Dis. Sci. 1988; 43:8-14.

  • 11. AMMENDOLA M. et al. Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated. Gastroentrol. Res. Pract. 2013; 2013: Article ID 703163 5 pages.

  • 12. BOWREY PF et al. Histamine mast cells and tumour cell proliferation in breast cancer: does preoperative cimetidine administration have an effect? Br J Cancer. 2000; 82(1):167-70.

  • 13. LACHTER J et al. Mast cells in colorectal neoplasias and premalignant disorders. Dis Colon Rectum. 1995; 38(3):290-3.

  • 14. DALLAS NA et al. Endoglin (CD105): a marker of tumor vasculature and potential target for therapy. Clin Cancer Res. 2008; 14(7):1931-1937.

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