Observational Case-Control Study on The Risk Factors of Fetal Macrosomia and Fetal-Maternal Associated Pathology

Open access


Background and aims: The purpose of this study was to evaluate the frequency of demographic and clinical risk factors for fetal macrosomia, maternal pregestational, gestational and intra partum pathology associated with macrosomia, and to investigate the dynamic of these parameters in a decade.

Material and method: We conducted two studies, a case-control study of 261 mothers who delivered macrosomic babies and 241 mothers who delivered normal weight babies in 2016, and then we compared the parameters obtained from the study group of 261women who delivered in 2016 macrosomic babies with those of a study group of 220 women who delivered macrosomic babies in 2006 at Gynecology I County Hospital of Cluj-Napoca. The data was stored and analyzed using Microsoft Excel.

Results and conclusions: Overweight before pregnancy, the excessive weight gain during pregnancy, and the delivery of a macrosomic baby increase the risk to deliver in the future a macrosomic baby. Mothers who delivered macrosomic babies had a higher incidence of thyroid gland pathology (hypofunction) and gestational diabetes than those who delivered normal weight babies.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Sahoo J Mitra S Nayk PK Kamalanathan S. Comment on prediction of neonates’ macrosomia with maternal lipid profile of healthy mothers Mossayebi et al. Pediatr Neonatol 55(6): 497-8 2014

  • 2. Araujo Junior E Peixoto AB Zamarian AC Elito Junior J Tonni G. Macrosomia. Best Pract Res Clin Obstet Gynaecol 38: 83-96 2017

  • 3. Pavlov E Dobrioglo I Ciobanu V. Risc factors in the macrosomic fetus birth. Vol 5. Accessed at: http://library.usmf.md:8080/jspui/handle/123456789/188 2013

  • 4. Zapata-Masias Y Margueta B Gomez R Bosquet EG. Obstetric and perinatal outcomes in women over 40 years of age: Association with fetal growth disorders. Early Hum Dev 100: 17-20 2016

  • 5. Koynagi A Zhang J Hirayama F et al. Macrosomia in 23 developing countries: an analysis of a multicounty facility-based cross-sectional survey. Lancet 381(9865): 476-83 2013

  • 6. World Health Organization. Obesity and overweight. Fact sheet (reviewed February 2018). Accessed at: http://www.who.int/mediacentre/factsheets/fs311/en

  • 7. AR Baur. Macrosomia Medscape. Accessed at: https://emedicine.medscape.com/article/262679-overview 2017

  • 8. Paladi Gh Cernețchi O. Fetal macrosomia; Fetal-pelvic disproportion. Obstetric pathology manual 2: 494-499 2007

  • 9. Wahlberg J Ekman B Nystrom L Hanson U Persson B Amquvist HJ. Gestational diabetes: Glycaemic predictors for fetal macrosomia and maternal risk of future diabetes. Diabetes Res Clin 114: 99-105 2016

  • 10. Reid EW McNeill JA Alderdice FA Tully MA Holmes VA. Physical activity sedentary behavior and fetal macrosomia in uncomplicated pregnancies: a prospective cohort study. Midwifery 30(12): 1202-9 2014

  • 11. Yang S Xiong C Yang R et al. Parental Body Mass Index Gestational Weight Gain and Risk of Macrosomia: a population-based case-control study in China. Paediatr Perinat Epidemiol 29(5): 462-71 2015

  • 12. Eichenwald EC Hansen AR Martin CR Stark AR. Cloherty and Starks Manual of Neonatal Care 8-th edition: pp: 1-14; 64-93 2016

  • 13. Kulkarni SR Kumaran K Rao SR et al. Maternal lipids are as important as glucose for fetal growth: findings from the Pune Maternal Nutrition Study. Diabetes Care 36(9): 2706-13 2013

  • 14. Romanian Society of Diabetes Nutrition and Diabetic Diseases (SRDBN). Clinical guide 2013

  • 15. Onubogu CU Equbounu I Ugochkwu EF Nwabueze AS Ugochkwu O. The influence of maternal anthropometric characteristics on the birth size of term singleton south-east Nigerian newborn infants. Niger J Clin Pract 20(7): 852-859 2017

  • 16. Ogonowski J Miazqowski T. Intergenerational transmission of macrosomia in women with gestational diabetes and normal glucose tolerance. Eur J Obstet Gynecol Reprod Biol 195: 113-6 2015

  • 17. Rawal S Tsai MY Hinkle SN et al. A Longitudinal Study of Thyroid Markers Across Pregnancy and the Risk of Gestational Diabetes J Clin Endocrinol Metab 103(7): 2447-2456 2018

  • 18. Vrijkolte TG Hrudey EJ Twickler MB. Early Maternal Thyroid Function During Gestation Is Associated with Fetal Growth Particularly in Male Newborns. J Clin Endocrinol Metab 102(3): 1059-1066 2017

  • 19. Grissa O Yessoufou A Tabka Z et al. Antioxidant status and circulating lipids are altered in human gestational diabetes and macrosomia. Transl Res 150(3): 164-71 2007.

Journal information
Impact Factor

CiteScore 2018: 0.19

SCImago Journal Rank (SJR) 2018: 0.128
Source Normalized Impact per Paper (SNIP) 2018: 0.229

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 169 169 13
PDF Downloads 178 178 24