A Comparative Assessment of Serum Vitamin C and Serum Lead Among Periodontitis and Diabetic Patient

Open access

Abstract

Background and Aims: Pre and post-operative nutritional status are not often tested on a consistent basis when patients are analyzed and diagnosed with Type 2 Diabetes Mellitus (T2DM) or have chronic periodontitis. Thus, this study pursues to evaluate the predictive value of serum vitamin C and lead levels in this population at baseline and after periodontal treatment.

Materials and Methods: In an interventional study setting we enrolled 120 subjects which were later categorized into four sub-groups: set 1 – individuals with chronic periodontitis, set 2 – individuals with T2DM, set 3 – individuals with T2DM and chronic periodontitis respectively set 4 - healthy individuals as control group. Scaling and root planing was performed only to individuals with periodontitis and T2DM. At baseline and 21 days after periodontitis treatment blood was obtained from the subjects and analysis of serum vitamin C and serum lead was done and data obtained was statisticaly analysed.

Results: ANOVA test showed baseline values of both the parameters to be statistically significant different between groups and within groups (p<0.001). Alteration was seen in the parameters postoperatively regarding serum vitamin C was increased and lead level decreased; paired t-test showed statistically significant difference (p<0.001).

Conclusion: Serum Vitamin C can be considered a key biomarker. Increased lead level can be a risk factor for commencement and progression of T2DM and chronic periodontitis.

1. Laires MJ, Monteiro CP, Bicho M. Role of cellular magnesium in health and human disease. Front Biosci 9: 262-276, 2004.

2. Houston DK, Johnson MA. Does vitamin C intake protect against lead toxicity? Nutr Rev 58(3 Pt 1): 73-75, 2000.

3. Van der Velden U, Kuzmanova D, Chapple IL. Micronutritional approaches to periodontal therapy. J Clin Periodontol 38: 142-158, 2011.

4. Pendyala G, Thomas B, Kumari S. The challenge of antioxidants to free radicals in periodontitis. J Indian Soc Periodontol 12: 79-83, 2008.

5. Thurnham DI, McCabe GP. Influence of infection and inflammation on biomarkers of nutritional status with an emphasis on vitamin A and iron. World Health Organization, 2012.

6. Wiebe CB, Putnins EE. The periodontal disease classification system of the American academy of periodontology- An Update. J Can Dent Assoc 66: 594-597, 2000.

7. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 33: S62-S69, 2010.

8. Shetty A, Bhandary R, Thomas B, Ramesh A. A Comparative evaluation of serum magnesium in diabetes mellitus type 2 patients with and without periodontitis - A clinico-biochemical study. J Clin Diagn Res 10: ZC59-ZC61, 2016.

9. Van Dyke TE. Proresolving lipid mediators : potential for prevention and treatment of periodontitis. J Clin Periodontol 38: 119-125, 2011.

10. Milward MR, Chapple ILC. The role of diet in periodontal disease. Dental Health 52: 18-21, 2013.

11. Will JC, Ford ES, Bowman BA. Serum vitamin C concentrations and diabetes: findings from the Third National Health and Nutrition Examination Survey. Am J Clin Nutr 70: 49-52, 1999.

12. Riemersma RA, Carruthers KF, Elton RA, Fox KA. Vitamin C and the risk of acute myocardial infarction. Am J Clin Nutr 71: 1181-1186, 2000.

13. Auyeung L, Wang PW, Lin RT, et al.. Evaluation of periodontal status and effectiveness of non-surgical treatment in patients with type 2 diabetes mellitus in Taiwan for a 1 – year period. J Periodontol 83: 621-628, 2012.

14. Shetty P, Kumari S. Serum total anti-oxidants, super oxide dismutase (SOD), myeloperoxidase and vitamin C levels in periapical inflammation- A Original Study. RJPBCS 3: 934-939, 2012.

15. Sies H, Jones DP. Oxidative stress. Encyclopedia of stress 3: 45-58, 2007.

16. Taylor RJ. Fact sheet: Nutrients that reduce lead poisoning. 2010. Accessed at: https://www.lead.org.au/fs/Fact_sheet-Nutrients_that_reduce_lead_poisoning_June_2010.pdf

17. Saraiva MCP, Taichman RS, Braun T, Nriagu J, Eklund SA, Burt BA. Lead exposure and periodontitis in US adults. J Periodont Res 42: 45-52, 2007.

18. Meerwaldt R, Links T, Zeebregts C, Tio R, Hillebrands JL, Smit A. The clinical relevance of assessing advanced glycation end products accumulation in diabetes. Cardiovasc Diabetol 7: 29, 2008.

19. Thomas B, Ramesh A, Suresh S, Prasad BR. A comparative evaluation of antioxidant enzymes and selenium in the serum of periodontitis patients with diabetes mellitus type 2. Contemp Clin Dent 4: 176-180, 2013.

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

The Journal of Romanian Society of Diabetes Nutrition and Metabolic Diseases

Journal Information


CiteScore 2017: 0.11

SCImago Journal Rank (SJR) 2017: 0.122
Source Normalized Impact per Paper (SNIP) 2017: 0.077

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 167 167 24
PDF Downloads 90 90 15