Cognitive Disorders, Depressive Status and Chronic Complications of Type 2 Diabetes Mellitus

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Abstract

Background and aims: Depression and cognitive disorders were reported more frequently in patients with diabetes mellitus (DM). Our aim was to analyze the association of cognitive disorders and depression association with chronic complications of DM in a group of Romanian patients. Materials and methods: The data was analyzed from 181 patients, with a mean age of 58,3 years to whom we applied the MMSE (Mini- Mental State Examination) and MADRS (Montgomery-Asberg Depression Rating Scale) questionnaires. We also analyzed the presence of chronic DM complications, HbA1c and lipid profile. Results: Most patients with type 2 diabetes mellitus (T2DM) had mild cognitive impairment (92%), more common in the age group 50-59 years. Chronic macrovascular complications were present in 74.58%, while chronic microvascular complications were present in 61.87% of patients with T2DM who associated mild and moderate cognitive impairment (p = 0.013). The most common form of depression was mild depression (90.2%), present in most patients with DM, regardless of progression and type of treatment. MADRS depression test scores were statistically significant correlated with the presence of peripheral artery disease - PAD (p <0.001), ischemic heart disease - IHD (p <0.001) and chronic kidney disease - CKD (p =0.05). We did not find a statistically significant correlation with HbA1c and serum lipid values (p˃0,05). Conclusion: Chronic diabetes macrovascular complications (PAD, IHD) and CKD were more frequently associated with cognitive disorders and depression in patients with T2DM independent of the degree of metabolic control.

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  • 1. Botts A Munshi M. Diabetes Education in Geriatric Population. In: Educating Your Patient with Diabetes.Weinger K (ed). Humana Press Boston pp 289-307 2009.

  • 2. Alagiakrishnan K1 Zhao N Mereu L Senior P Senthilselvan A. Montreal cognitive assessment is superior to Standardized Mini-Mental Status Exam in detecting mild cognitive impairment in the middle-aged and elderly patients with type 2 diabetes mellitus. Biomed Res Int 2013:186106 2013.

  • 3. Petrak F Herpertz S Albus C et al. Study protocol of the Diabetes and Depression Study (DAD): a multi-center randomized controlled trial to compare the efficacy of a diabetes-specific cognitive behavioral group therapy versus sertraline in patients with major depression and poorly controlled diabetes mellitus. BMC Psychiatry 13: 206 2013.

  • 4. Cukierman T Gerstein HC Williamson JD. Cognitive decline and dementia in diabetes - a systematic overview of prospective observational studies. Diabetologia 42: 2460-2469 2005.

  • 5. Cox DJ Kovatchev BP Gonder-Fredrerick LA et al. Relationships between hyperglycemia and cognitive performance among adults with type 1 and type 2 diabetes. Diabetes Care 28: 71-77 2005.

  • 6. Cukierman-Yaffe T Gerstein HC Williamson JD et al. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial. Diabetes Care 32: 221-226 2009.

  • 7. Lam RW. Introduction. In: Depression. Lam RW (ed). Oxford University Press Oxford pp 1-5 2012.

  • 8. Holt RI de Groot M Lucki I Hunter CM Sartorius N Golden SH. NIDDK international conference report on diabetes and depression: current understanding and future directions. Diabetes Care 37: 2067-2077 2014.

  • 9. Maes M Meltzer HY. The serotonin hypothesis of major depression. In: Psychopharmacology: the fourth generation of progress. Bloom FE Kupfer DJ (ed). Raven Press New York pp 933-944 1995.

  • 10. Hayashino Y Mashitani T Tsujii S Ishii H; Diabetes Distress and Care Registry at Tenri Study Group. Elevated levels of hs-CRP are associated with high prevalence of depression in japanese patients with type 2 diabetes: the Diabetes Distress and Care Registry at Tenri (DDCRT 6). Diabetes Care 37: 2459-2465 2014.

  • 11. Slovácek L Slovácková B Chovanec V. Ischemic disease of the lower extremities versus depression symptoms and quality of life. Cas Lek Cesk 145: 788-791 2006.

  • 12. Poongothai S Anjana RM Pradeepa R et al. Association of depression with complications of type 2 diabetes - the Chennai Urban Rural Epidemiology Study (CURES- 102). J Assoc Physicians India 59:644-648 2011.

  • 13. Bajaj S Agarwal SK Varma A Singh VK. Association of depression and its relation with complications in newly diagnosed type 2 diabetes. Indian J Endocrinol Metab 16: 759-763 2012.

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