The hypothesis that under some circumstances enteroviral infections can lead to type1 diabetes (T1D) was proposed several decades ago, based initially on evidence fromanimal studies and sero-epidemiology. The mechanisms leading to the diseaseinvolve complex interactions between the virus, host target tissue (pancreas) and theimmune system. The following article is intended as a review of several recentinformation of the topic based on human studies that try to establish a connectionbetween a viral infection and Type 1 diabetes. Through understanding better thisassociation and it’s implications in the onset of T1D potential new ways ofprevention and treatment may emerge.
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1. Hober D Sane F Jaïdane H Riedweg K Goffard A Desailloud R. Immunology in the clinic review series; focus on type 1 diabetes and viruses: role of antibodies enhancing the infection with Coxsackievirus-B in the pathogenesis of type 1 diabetes. Clin Exp Immunol 168: 47-51 2012.
2. Lind K Hühn MH Flodström-Tullberg M. Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes. Clin Exp Immunol 168: 30-38 2012.
3. Coppieters KT Wiberg A Tracy SM von Herrath MG. Immunology in the clinic review series: focus on type 1 diabetes and viruses: the role of viruses in type 1 diabetes: a difficult dilemma.cClin Exp Immunol 168: 5-11 2012.
4. Yeung WC Rawlinson WD Craig MA. Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies. BMJ 342: d35 2011.
5. Stene LC Rewers M. Immunology in the clinic review series; focus on type 1 diabetes and viruses: the enterovirus link to type 1 diabetes: critical review of human studies. Clin Exp Immunol 168: 12-23 2012.
6. Gale EAM. Viruses and type 1 diabetes: ignorance acquires a better vocabulary. Clin Exp Immunol 168: 1-4 2012.
7. Vehik K Dabelea D. The changing epidemiology of type 1 diabetes: why is it going through the roof? Diabetes Metab Res Rev 27: 3-13 2011.
8. Kondrashova A Reunanen A Romanov A et al. A six-fold gradient in the incidence of type 1 diabetes at the eastern border of Finland. Ann Med 37: 67-72 2005.
9. Tracy S Drescher KM Jackson JD Kim K Kono K. Enteroviruses type 1 diabetes and hygiene: a complex relationship. Rev Med Virol 20: 106-116 2010.
10. Getts MT Miller SD. 99th Dahlem conference on infection inflammation and chronic inflammatory disorders: triggering of autoimmune diseases by infections. Clin Exp Immunol 160: 15-21 2010.
11. Stetson DB Medzhitov R. Antiviral defense: interferons and beyond. J Exp Med 203: 1837-1841 2006.
12. Stene LC Tuomilehto J Rewers M. Global epidemiology of type 1 diabetes. In: The epidemiology of diabetes mellitus. Ekoé J-M Rewers M Williams R Zimmet P eds. Chichester: Wiley-Blackwell pp 355-383 2008.
13. Gamble DR Kinsley ML FitzGerald MG Bolton R Taylor KW. Viral antibodies in diabetes mellitus. BMJ 3(5671): 627-630 1969.
14. Gundersen E. Is diabetes of infectious origin? J Infect Dis 41: 197-202 1927.
15. Gale EAM. Congenital rubella: citation virus or viral cause of type 1 diabetes? Diabetologia 51: 1559-1566 2008.