LncRNA NEAT1 promotes endometrial cancer cell proliferation, migration and invasion by regulating the miR-144-3p/EZH2 axis
Article Category: Research Article
Published Online: Nov 20, 2019
Page range: 434 - 442
Received: May 22, 2019
Accepted: Sep 21, 2019
DOI: https://doi.org/10.2478/raon-2019-0051
© 2019 Wei Wang, Liang Ge, Xiao-Juan Xu, Ting Yang, Yue Yuan, Xiao-Ling Ma, Xue-Hong Zhang, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Background
Endometrial cancer (EC) is one of the most common gynaecological tumours in the worldwide. Long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) promotes cell proliferation, migration and invasion in EC cells. However, the molecular mechanisms of NEAT1 in EC have not been fully clarified. We conducted this study to reveal the function of NEAT1 in EC tissues and cell lines.
Materials and methods
Cancer and adjacent tissues were collected from EC patients. HEC-1A and Ishikawa cells were cultured
Results
NEAT1 was highly expressed in EC tissues and cells. Knockdown of NEAT1 inhibited the proliferation, migration and invasion of EC cells. Additionally, NEAT1 acted as a ceRNA of miR-144-3p, leading to EZH2 upregulation. Overexpression of miR-144-3p suppressed the proliferation and invasion of EC cells.
Conclusions
NEAT1 promotes EC cells proliferation and invasion by regulating the miR-144-3p/EZH2 axis.