Health-related quality of life assessed by the EORTC QLQ-C30 questionnaire in the general slovenian population

Vaneja Velenik 1 , Ajra Secerov-Ermenc 1 , Jasna But-Hadzic 1 , and Vesna Zadnik 2
  • 1 Institute of Oncology Ljubljana, Division of Radiotherapy, Ljubljana, Slovenia
  • 2 Institute of Oncology Ljubljana, Epidemiology and Cancer Registry, Ljubljana, Slovenia
Vaneja Velenik, Ajra Secerov-Ermenc, Jasna But-Hadzic and Vesna Zadnik
  • Corresponding author
  • Institute of Oncology Ljubljana, Epidemiology and Cancer Registry, Ljubljana, Slovenia
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Abstract

Background

The aim of our study was to obtain reference data of the EORTC QLQ-C30 quality of life dimensions for the general Slovenian population. We intend to provide the researchers and clinicians in our country with the expected mean health-related quality of life (HRQL) scores for distinctive socio-demographic population groups.

Methods

The EORTC QLQ-C30 questionnaire supplemented by a socio-demographic inquiry was mailed or distributed to 1,685 randomly selected individuals in the Slovenian population aged 18 – 90. Answers from 1,231 subjects representing socio-demographic diversity of the Slovenian population were collected and transformed into EORTC dimensions and symptoms. The impact of socio-demographic features on HRQL scores was assessed by multiple linear regression models.

Results

Gender, age and self-rated social class are the important confounders in the quality of life scores in our population. Men reported better quality of life on the majority of the specific scales and, at the same time, reported fewer symptoms. There was no gender-specific difference in cognitive functioning. The mean scores were consistently lower with age in both sexes.

Conclusions

This is the first study to report the normative EORTC QLQ-C30 scores for one of the south-eastern European populations. The reported expected mean scores allow Slovenian oncologists to estimate what the quality of life in cancer patients would be, had they not been ill. As they are derived by common methodology, our results can easily be included in any further international comparisons or in the calculation of European summarized HRQL scores.

  • 1

    Zadnik V, Primic Zakelj M, Lokar K, Jarm K, Ivanus U, Zagar T. Cancer burden in Slovenia with the time trends analysis. Radiol Oncol 2017; 51: 47-55.

    • Crossref
    • PubMed
    • Export Citation
  • 2

    Primic Žakelj M, Zadnik V, Žagar T, Zakotnik B. Survival of Cancer Patients in Slovenia 1991-2005. Ljubljana: Institute of Oncology Ljubljana; 2009.

  • 3

    Juul T, Petersen MA, Holzner B, Laurberg S, Christensen P, Gronvold M. Danish population-based reference data for the EORTC QLQ-C30: associations with gender, age and morbidity. Qual Life Res 2014; 23: 2183-93.

    • Crossref
    • PubMed
    • Export Citation
  • 4

    Luckett T, King MT, Butow PN, Oguchi M, Rankin N, Price MA, et al. Choosing between the EORTC QLQ-C30 and FACT-G for measuring health-related quality of life in cancer clinical research: issues, evidence and recommendations. Ann Oncol 2011;22: 2179-90.

    • Crossref
    • PubMed
    • Export Citation
  • 5

    Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez N J, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993; 85: 365-76.

    • Crossref
    • PubMed
    • Export Citation
  • 6

    Life ESG oQo. EORTC QLQ-C30 (version 3.0.) Slovenian. Brussels: EORTC; 1996.

  • 7

    Klee M, Groenvold M, Machin D. Quality of life of Danish women: population-based norms of the EORTC QLQ-C30. Qual Life Res 1997; 6: 27-34.

    • PubMed
    • Export Citation
  • 8

    Hjermstad MJ, Fayers PM, Bjordal K, Kaasa S. Health-related quality of life in the general Norwegian population assessed by the European Organization for Research and Treatment of Cancer Core Quality-of-Life Questionnaire: the QLQ=C30 (+ 3). J Clin Oncol 1998; 16: 1188-96.

    • Crossref
    • PubMed
    • Export Citation
  • 9

    Derogar M, van der Schaaf M, Lagergren P. Reference values for the EORTC QLQ-C30 quality of life questionnaire in a random sample of the Swedish population. Acta Oncol 2012; 51: 10-6.

    • Crossref
    • Export Citation
  • 10

    Michelson H, Bolund C, Nilsson B, Brandberg Y. Health-related quality of life measured by the EORTC QLQ-C30--reference values from a large sample of Swedish population. Acta Oncol 2000; 39: 477-84.

    • Crossref
    • PubMed
    • Export Citation
  • 11

    Schwarz R, Hinz A. Reference data for the quality of life questionnaire EORTC QLQ-C30 in the general German population. Eur J Cancer 2001; 37: 1345-51.

    • Crossref
    • PubMed
    • Export Citation
  • 12

    Waldmann A, Schubert D, Katalinic A. Normative data of the EORTC QLQ-C30 for the German population: a population-based survey. PLoS One 2013; 8: e74149.

    • Crossref
    • PubMed
    • Export Citation
  • 13

    van de Poll-Franse LV, Mols F, Gundy CM, Creutzberg CL, Nout RA, Verdonckde Leeuw IM, et al. Normative data for the EORTC QLQ-C30 and EORTC-sexuality items in the general Dutch population. Eur J Cancer 2011; 47: 667-75.

    • Crossref
    • PubMed
    • Export Citation
  • 14

    Finck C, Barradas S, Singer S, Zenger M, Hinz A. Health-related quality of life in Colombia: reference values of the EORTC QLQ-C30. Eur J Cancer Care (Engl) 2012; 21: 829-36.

    • Crossref
    • PubMed
    • Export Citation
  • 15

    Park SY, Bae DS, Nam JH, Park CT, Cho CH, Lee JM, et al. Quality of life and sexual problems in disease-free survivors of cervical cancer compared with the general population. Cancer 2007; 110: 2716-25.

    • Crossref
    • PubMed
    • Export Citation
  • 16

    Yun YH, Kim YA, Min YH, Chang YJ, Lee J, Kim M S, et al. Health-related quality of life in disease-free survivors of surgically treated lung cancer compared with the general population. Ann Surg 2012; 255: 1000-7.

    • Crossref
    • PubMed
    • Export Citation
  • 17

    Hinz A, Singer S, Brahler E. European reference values for the quality of life questionnaire EORTC QLQ-C30: Results of a German investigation and a summarizing analysis of six European general population normative studies. Acta Oncol 2014; 53: 958-65.

    • Crossref
    • Export Citation
  • 18

    Fayers PM. Interpreting quality of life data: population-based reference data for the EORTC QLQ-C30. Eur J Cancer 2001; 37: 1331-4.

    • Crossref
    • PubMed
    • Export Citation
  • 19

    Scott NW, Fayers PM, Aaronson NK, Bottomley A, de Graeff A, Groenvold M, et al. The use of differential item functioning analyses to identify cultural differences in responses to the EORTC QLQ-C30. Qual Life Res 2007; 16: 115-29.

    • Crossref
    • PubMed
    • Export Citation
  • 20

    SI-Stat Data Portal. SURS. [citated 2016 Aug 31 ]. Available at: http://pxweb.stat.si/pxweb/dialog/statfile1.asp

  • 21

    Maucec Zakotnik J, Tomsic S, Kofol-Bric T, Korosec A. Health and lif style in Slovenian population. Trends from CINDI researches 2001-2004-2008; in Slovene. [Slovenian]. Ljubljana: IVZ; 2012.

  • 22

    Fayers P, Aaronson N, Bjordal K, Groenvold M, Curran D, Bottomley A. EORTC QLQ-C30 Scoring Manual(Third edition ed.). Brussels: EORTC; 2001.

  • 23

    Hjermstad MJ, Fayers PM, Bjordal K, Kaasa S. Using reference data on quality of life--the importance of adjusting for age and gender, exemplified by the EORTC QLQ-C30 (+3). Eur J Cancer 1998; 34: 1381-9.

    • Crossref
    • PubMed
    • Export Citation
  • 24

    Zadnik V. Geografska analiza vpliva socialno-ekonomskih dejavnikov na incidenco raka v Sloveniji v obdobju 1995-2002 [Geographical analysis of the association of socioeconomic status and cancer incidence in Slovenia in the period 1995-2002; in Slovene]. [PhD thesis]. Ljubljana: University of Ljubljana; 2006.

  • 25

    Farkaš J, Pahor M, Zaletel-Kragelj L. Self-rated health in different social classes of Slovenian adult population: nationwide cross-sectional study. Int J Public Health 2011; 56: 45-54.

    • Crossref
    • PubMed
    • Export Citation
  • 26

    Fossa SD, Hess SL, Dahl AA, Hjermstad MJ, Veenstra M. Stability of health-related quality of life in the Norwegian general population and impact of chronic morbidity in individuals with and without a cancer diagnosis. Acta Oncol 2007; 46: 452-61.

    • Crossref
    • PubMed
    • Export Citation
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