Red blood cell transfusion and skeletal muscle tissue oxygenation in anaemic haematologic outpatients
Article Category: Research Article
Published Online: Nov 09, 2016
Page range: 449 - 455
Received: Jul 03, 2015
Accepted: Aug 06, 2015
DOI: https://doi.org/10.1515/raon-2015-0046
© 2016 Radiol Oncol
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Background
Stored red blood cells (RBCs) accumulate biochemical and biophysical changes, known as storage lesion. The aim of this study was to re-challenge current data that anaemia in chronically anaemic haematology patients is not associated with low skeletal muscle tissue oxygen (StO2), and that RBC storage age does not influence the tissue response after ischaemic provocation, using near-infrared spectroscopy.
Patients and methods
Twenty-four chronic anaemic haematology patients were included. Thenar skeletal muscle StO2 was measured at rest (basal StO2), with vascular occlusion testing (upslope StO2, maximum StO2) before and after transfusion.
Results
Basal StO2 was low (53% ± 7%). Average RBC storage time was 10.5 ± 3.9 days. Effects of RBC transfusions were as follows: basal StO2 and upslope StO2 did not change significantly; maximum StO2 increased compared to baseline (64 ± 14%
Discussion
Resting skeletal muscle StO2 in chronic anaemic patients is low. RBC storage time affects skeletal muscle StO2 in the resting period and after ischaemic provocation.