Case report from Mayo Clinic: Locally advanced Bartholin gland carcinoma
Tumors of the Bartholin gland are rare, comprising less than 5% of all vulvar malignancies. Treatment is largely based on that of vulvar and anal squamous cell carcinomas. A case of invasive, grade 4, poorly differentiated squamous cell carcinoma of the Bartholin gland is presented. Our patient, a 47-year-old woman, had a history significant for cervical intraepithelial neoplasia treated with conization, type 2 diabetes mellitus, and tobacco use. The course of treatment included preoperative radiotherapy plus 5-fluorouracil and cisplatin chemotherapy, followed by restaging and posterior exenteration in combination with vaginal reconstruction.
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Elkas JC Berek JS. Clinical manifestations diagnosis pathology and staging of vulvar cancer. UpToDate Patient Information [homepage on the Internet]. UpToDate Inc.; c2007 [cited 2007 Mar 5]. Available from: http://uptodate.com
Chen KT. Disorders of Bartholin's gland. UpToDate Patient Information [homepage on the Internet]. UpToDate Inc.; c2007 [cited 2007 Mar 5]. Available from: http://uptodate.com
Moore DH Thomas GM Montana GS Saxer A Gallup DG Olt G. Preoperative chemoradiation for advanced vulvar cancer: a phase II study of the Gynecologic Oncology Group. Int J Radiat Oncol Biol Phys 1998; 42: 79-85.
Han SC Kim DH Higgins SA Carcangiu M-L Kacinski BM. Chemoradiation as primary or adjuvant treatment for locally advanced carcinoma of the vulva. Int J Radiat Oncol Biol Phys 2000; 47: 1235-44.
Rotman M Lange CS. Anal cancer: radiation and concomitant continuous infusion chemotherapy. Int J Radiat Oncol Biol Phys 1991; 21: 1385-7.
Bartelink H Roelofsen F Eschwege F Rougier P Bosset JF Gonzalez Gonzalez D et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. J Clin Oncol 1997; 15: 2040-9.
UKCCCR Anal Cancer Trial Working Party UK Co-ordinating Committee on Cancer Research. Epidermoid anal cancer: results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy 5-fluorouracil and mitomycin. Lancet 1996; 348: 1049-54.
Flam M John M Pajak TF Petrelli N Myerson R Doggett S et al. Role of mitomycin in combination with fluorouracil and radiotherapy and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. J Clin Oncol 1996; 14: 2527-39.
Mundt AJ Lujan AE Rotmensch J Waggoner SE Yamada SD Fleming G et al. Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies. Int J Radiat Oncol Biol Phys 2002; 52: 1330-7.
Mundt AJ Roeske JC Lujan AE. Intensity-modulated radiation therapy in gynecologic malignancies. Med Dosim 2002; 27: 131-6.
Mundt AJ Roeske JC Lujan AE Yamada SD Waggoner SE Fleming G et al. Initial clinical experience with intensity-modulated whole-pelvis radiation therapy in women with gynecologic malignancies. Gynecol Oncol 2001; 82: 456-63.
Roeske JC Lujan A Rotmensch J Waggoner SE Yamada D Mundt AJ. Intensity-modulated whole pelvis radiation therapy in patients with gynecologic malignancies. Int J Radiat Oncol Biol Phys 2000; 48: 1613-21.
Garofalo MC Lujan AE Mundt AJ. Intensity-modulated radiation therapy in the treatment of vulvar carcinoma: a feasibility study [abstract]. Radiology 2002; 225 Suppl: 597.
Mell LK Schomas DA Salama JK et al. Multi-institutional analysis of dosimetric predictors of acute hematologic toxicity in anal cancer patients treated with concurrent chemotherapy and intensity modulated radiation therapy (IMRT). Int J Radiat Oncol Biol Phys In press.
Salama JK Mell LK Schomas DA et al. Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: a multicenter experience. Int J Radiat Oncol Biol Phys In press.