A Pilot Study on Markers of Genetic Predisposition in Tuberculous Pneumonia Patients In Latgale

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Tuberculosis (TB) is still one of the top ten leading causes of death in the world. Compared to other Baltic and Eastern European countries, TB incidence (24.8 new cases per 100 000 people in 2017) in Latvia is relatively high. One of the regions with the highest TB incidence is Latgale (31.1 cases per 100 000 people). The aim of this pilot study was to identify markers of genetic predisposition to TB in Latgale. The study included 26 patients (16 males and 10 females) aged between 18 and 85 with bilateral TB pneumonia and without HIV infection. HLA typing was performed in HLA-DRB1, -DQA1, and -DQB1 loci by a polymerase chain reaction with low resolution sequence-specific primers. HLA-DRB1*07 and HLA-DRB1*11 alleles were identified as risk alleles for TB. HLA-DRB1*15 allele was a protective allele. Due to the limitations of this exploratory study, a broader study needs to be conducted to revealing specific risk and protective HLA Class II alleles for TB in the subpopulation of Latgale.

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  • Amirzargar A. A. Yalda A. Hajabolbaghi M. Khosravi F. Jabbari H. Rezaei N. Niknam M. H. Ansari B. Moradi B. Nikbin B. (2004). The association of HLA-DRB DQA1 DQB1 alleles and haplotype frequency in Iranian patients with pulmonary tuberculosis. Int. J. Tuberc. Lung Dis. 8 1017–1021.

  • Anonymous (2002). Latgales Reģiona Attīstības Aģentūra. Par Latgali. Vispārīga informācija [Latgale Region Development Agency. About Latgale. General Information] (in Latvian). Available from: http://www.latgale.lv/lv/about/summary (accessed 17 October 2018).

  • Anonymous (2017). World Health Organization. Tuberculosis surveillance and monitoring in Europe 2017. Available from: https://ecdc.europa.eu/sites/portal/files/documents/ecdc-tuberculosis-surveillance-monitoring-Europe-2017-WEB.pdf (accessed 17 October 2018).

  • Anonymous (2018). Slimību profilakses un kontroles centrs. Statistika un pētījumi. Tuberkuloze [Center for Disease Prevention and Control. Statistics and studies. Tuberculosis] (in Latvian). Available from: https://www.spkc.gov.lv/lv/statistika-un-petijumi/infekcijas-slimibas/datu-vizualizacija/tuberkuloze (accessed 17 October 2018).

  • Duarte R. Carvalho C. Pereira C. Bettencourt A. Carvalho A. Villar M. Domingos A. Barrosb H. Marques J. Pinho Costa P. Mendonça D. Martins B. (2011). HLA class II alleles as markers of tuberculosis susceptibility and resistance. Rev. Port. Pneumol.17 (1) 15–19.

  • Dubaniewicz A. Moszkowska G. Szczerkowska Z. (2005). Frequency of DRB1–DQB1 two-locus haplotypes in tuberculosis: Preliminary report. Tuberculosis 85 259–267.

  • Kim H. S. Park M. H. Song E. Y. Park H. Kwon S. Y. Han S. K. Shimet Y.-S. (2005). Association of HLA-DR and HLA-DQ genes with susceptibility to pulmonary tuberculosis in Koreans: Preliminary evidence of associations with drug resistance disease severity and disease recurrence. Hum. Immunol.66 1074–1081.

  • Kovalchuka L. Cvetkova S. Trofimova J. Eglite J. Gintere S. Lucenko I. Oczko-Grzesik B. Viksna L. Krumina A. (2016). Immunogenetic markers definition in Latvian patients with lyme borreliosis and lyme neuroborreliosis. Int. J. Environ. Res. Public Health 13 (12) 1194.

  • Kuranov A. Kozhamkulov U. Vavilov M. Belova E. Bismilda V. Alenova A. Ismailov S. Momynaliev K. (2014). HLA-class II alleles in patients with drug-resistant pulmonar tuberculosis in Kazakhstan. Tissue Antigens 83 106–112.

  • Li C.-P. Zhou Y. Xiang X. Zhou Y. He M. (2015). Relationship of HLA-DRB1 gene polymorphism with susceptibility to pulmonary tuberculosis: Updated meta-analysis. Int. J. Tuberc. Lung Dis. 19 (7) 841–849.

  • Mishra G. Kumar N. Kaur G. Jain S. Tiwari P. K. Mehra N. K. (2014). Distribution of HLA-A B and DRB1 alleles in Sahariya tribe of North Central India: An association with pulmonary tuberculosis. Infection Genetics and Evolution22 175–182.

  • Ruggiero G. Cosentini E. Zanzi D. Sanna V. Terrazzano G. Matarese G. Sanduzzi A. Perna F. Zappacosta S. (2004). Allelic distribution of human leucocyte antigen in historical and recently diagnosed tuberculosis patients in Southern Italy. Immunology111 318–322.

  • Starshinova A. A. Korneva N. V. Dovgalyuk I. F. Pavlova M. V. Pavlova I. E. Bubnova L. N. (2015). Influence of HLA-DRB1* allelic sets on the development of tuberculosis in children [Старшинова А.А. Корнева Н.В. Довгалюк И.Ф. Павлова М.В. Павлова И.Е. Бубнова Л.Н. Влияние аллелей генотипа HLA-DRB1* на развитие туберкулеза у детей]. Medical Immunology [Медицинская иммунология] 17 (3) 275–280 (in Russian).

  • Sveinbjornsson G. Gudbjartsson D. F. Halldorsson B. V. Kristinsson K. G. Gottfredsson M. Barrett J. C. Gudmundsson L. J. Blonda K. Gylfason A. Gudjonsson S. A. Helgadottir H. T. Jonasdottir A. Jonasdottir A. Karason A. Kardum L. B. Knežević J. Kristjansson H. Kristjansson M. Love A. Luo Y. Magnusson O. T. Sulem P. Kong A. Masson G. Thorsteinsdottir U. Dembic Z. Nejentsev S. Blonda T. Jonsdottir I. Stefansson K. (2016). HLA class II sequence variants influence tuberculosis risk in populations of European ancestry. Nat. Genet.48 (3) 318–322.

  • Wang J. Song C. Wang S. (2001). Association of HLA-DRB1 genes with pulmonary tuberculosis. Chinese J. Tuberc. Respir. Dis. [Zhonghua jie he he hu xi za zhi] 24 302–305 (in Chinese).

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