Persistent organic pollutants (POPs) are chemical substances that persist in the environment, bioaccumulate through the food web, and pose a risk of causing adverse effects to human health and the environment. The aim of the study was to assess the POP (polychlorinated biphenyls (PCBs), polybrominated diphenylethers (PBDEs), DDT and their derivatives) levels in blood serum to identify possible risk group workers. Blood serum samples (116 in total) were collected from two groups of employees — electricians, who can come in contact with PCB-containing transformer and capacitor oil, and welders, who were used as a control group. Sample purification was done by double solid phase extraction. The concentrations of POPs in blood serum were determined by gas chromatography with electron capture detector GC/ECD and recovery controlled by internal standard CB-174. None of the 116 samples contained the full range of tested POPs. However, all samples contained at least one of pesticides, and a marker PCB and mono-ortho PCB. Blood serum samples of 52% of electricians and 97.8% of welders contained non-ortho PCB compared to 84% and 74.7%, respectively, for PBDE’s. The concentrations of 18 detected PCBs, 4 detected PBDEs and 6 chlorinated pesticides and their metabolites varied in wide ranges and the differences in mean values between groups were not statistically significant (p > 0.05). The estimated concentrations of POPs correspond to the lowest levels detected in other countries. Mean concentrations of low-chlorinated marker PCBs were higher in the electrician group, suggesting that the employment sites are contaminated with PCBs, or that employees have contact with PCB-containing items.
Anonymous (2003). The Air Toxics Hot Spots Program Guidance Manual for Preparation of Health Risk Assessments. August 2003. Appendix E, Toxicity Equivalency Factors for Polychlorinated Dibenzo-p-Dioxins Dibenzofurans And Polychlorinated Biphenyls. Available at: http://oehha.ca.gov/air/hot_spots/pdf/HRAguidefinal.pdf (accessed 30 September 2016).
Anonymous (2004). Toxicological Profile for Polybrominated Biphenyls and Polybrominated Diphenyl Ethers. Agency for Toxic Substances and Disease Registry. September 2004. Available at: http://www.atsdr.cdc.gov/ToxProfiles/tp68.pdf (accessed 30 September 2016).
Anonymous (2000a). Air Quality Guidelines for Eirope. Second Edition, Chapter 5.10 PCBs, WHO Regional Office for Europe, Copenhagen, 2000. 288 pp.
Anonymous (2000b). Interlaboratory Quality Assessment of Levels of PCBs, PCDDs and PCDFs, in Human Milk and Blood Plasma: Fourth Round of WHO-coordinated study. WHO, Copenhagen. 56 pp.
Broding, H. C., Schettgen, T., Hillert, A., Angerer, J., Göen, T., Drexler H. (2008). Subjective complaints in persons under chronic low-dose exposure to lower polychlorinated biphenyls (PCBs). Int. J. Hyg. Environ. Health, 211, 648–657.
Broding, H. C., Schettgen, T., Göen, T., Angerer, J., Drexler H. (2007). Development and verification of a toxicokinetic model of polychlorinated biphenyl elimination in persons working in a contaminated building. Chemosphere, 68, 1427–1434.
Draper, W. M., Liang, J., Fowler, M., Kharrazi, M., Flessel, F. P., Perera S. K. (2007). Testing for Persistent Organic Pollutants in Banked Maternal Serum Specimens. In: Krieger, R. I., Ragsdale, N., Seiber, J. N. (eds.). Assessing Exposures and Reducing Risks to People from the Use of Pesticides. ACS Symposium Series, Vol. 951, Chapter 4. Oxford University Press, Oxford, pp. 49–69.
Hopf, N. B., Ruder, A. M., Succop, P. (2009). Background levels of polychlorinated biphenyls in the U.S. population. Sci. Total Environ., 407, 6109–6119.
Jackson, L. W., Lynch, C. D., Kostyniak, P. J., McGuinness, B. M., Louis, G. M. (2010). Prenatal and postnatal exposure to polychlorinated biphenyls and child size at 24 months of age. Reprod. Toxicol., 25–31.
Glynn, A., Aune, M., Darnerud, P. O., Bjerselius, R., Becker, W., Lignell, S. (2007). Determinants of serum concentrations of organochlorine compounds in Swedish pregnant women: A cross-sectional study. Environ. Health, 6, 2.
Guvenius, M. D., Aronsson, A., Ekman-Ordeberg, G., Bergman, A., Noren, K. (2003). Human prenatal and postnatal exposure to polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorobiphenylols and pentachlorophenol. Environ. Health Perspect., 111, 1235–1241.
Kočan, A., Petrik, J., Drobna, B., Chovancova, J. (1994). Levels of PCBs and some organochlorine pesticides in the human population of selected areas of the Slovak Republic. Chemosphere, 29, 9–11.
Liebl, B., Schettgen, T., Kerscher, G., Broding, H. C., Angerer, J., Drexler, H., Otto, A. (2004). Evidence for increased internal exposure to lower chlorinated polychlorinated biphenyls (PCB) in pupils attending a contaminated school. Int. J. Hyg. Environ. Health, 207, 315–324.
Lung, S.-C. C., Guo, Y.-L. L., Chang, H.-Y. (2005). Serum concentrations and profiles of polychlorinated biphenyls in Taiwan Yu-cheng victims twenty years after the incident. Environ. Pollut., 136, 71–79.
Peters, R. J. B. (2004). Man-Made Chemicals in Human Blood. Netherlands Organisation for Applied Scientific Research (TNO). 60 pp.
Sjödin, A., Hagmar, L., Klasson-Wehler, E., Kronholm-Diab, K., Jakobsson, E., Bergman, A. (1999). Flame retardant exposure: polybrominated diphenyl ethers in blood from Swedish workers. Environ. Health Perspect., 107 (8), 643–648.
Teibe, U. (2007). Bioloģiskā statistika [Biological Statistics]. LU akadēmiskais apgāds, Rīga. 156 lpp.
Teibe, U., Berķis, U. (2001). Varbūtību teorijas un matemātiskās statistikas elementi medicīnas studentiem [Elements of Probability Theory and Mathematical Statistics for Medical Students]. AML/RSU, Rīga. 88 lpp.
Thomas, G. O., Wilkinson, M., Hodson, S., Jones, K. C. (2006). Organohalogen chemicals in human blood from the United Kingdom. Environ. Pollut., 141, 30–41.
Toms, L., Harden, H., Holson, P., Päpke, O., Jake, J., Müller, R., Müller, J. (2006). Assessment of the Concentrations of Polybrominated Diphenyl Ether Flame Retardants in the Australian Population: Levels in Blood. National Research Centre for Environmental Toxicology, Canberra. 77 pp.
Ross, G. (2004). The public health implications of polychlorinated biphenyls (PCBs) in the environment. Ecotoxicol. Environ. Safety, 59 (3), 275–291.
Walizewski, S. M., Aguire, A. A., Benitez, A., Infanzon, R. M., Infanzon, R. (1999). Organoshlorine pesticide residues in human blood serum of inhabitants of Veracruz, Mexico. Bull. Environ. Contam. Toxicol., 62, 397–402.