Late Onset of Pancreatic Metastases from Renal Cell Carcinoma. A Case Report

Vesna Janevska 1 , Aleksandar Shumkovski 2 , Dafina Nikolova 3 , Learta Asani 4 , Stefan Pandilov 1 , and Vlatko Karanfilovski 1
  • 1 Institute for Pathology, Faculty of Medicine, Macedonia, Skopje
  • 2 University Clinic for Abdominal Surgery, , Republic of North Macedonia, Skopje
  • 3 University Clinic of Gastroenterohepatology, , Republic of North Macedonia, Skopje
  • 4 City General Hospital 8th September, , Republic of North Macedonia, Skopje

Abstract

Metastasis of renal cell carcinoma (RCC) to the pancreas is a rare entity accounting only 0.25–3% of all pancreatic tumors. We present a rare case of isolated three focal pancreatic metastases from RCC, occurring 15 years after the left nephrectomy. The majority of the pancreatic metastases are asymptomatic, as it was in case of our patient excluding the weight loss for the last three months. We demonstrate the importance of the medical history, radiological examinations, histological and immunohistochemical analysis in making a definitive diagnosis.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Katsourakis A, Noussios G, Hadjis I, Alatsakis M, Chatzitheoklitos E.Late Solitary Pancreatic Metastasis from Renal Cell Carcinoma: A Case Report. Case Rep Med.2012; 2012: 464808 doi:10.1155/2012/464808

  • 2. Sanghwa K, Sungpil Y, Suk K,Tae-nam K, Hyung-Il S.Pancreatic resection for renal cell carcinoma metastasis: a case review. Ann Hepatobiliary Pancreat Surg. 2017; 21(3): 176–179. doi: 10.14701/ahbps.2017.21.3.176 PMid: 28990007 PMCid: PMC5620481

  • 3. Thadani A, Pais S, Savino J. Metastasis of Renal Cell Carcinoma to the Pancreas 13 Years Post-Nephrectomy. GastroenterolHepatol (N Y). 2011; 7(10): 697–699. PMid: 22298966PMCid: PMC3265015

  • 4. Kling SM, Tannouri S, Jiang W, Yeo CJ. Pancreatic Mass in a Patient with a History of Resected Renal Cell Carcinoma and Resected Adenocarcinoma of the Ampulla of Vater: A Case Report. J Pancreat Cancer. 2018; 4(1): 41–44. doi: 10.1089/pancan.2018.0001. eCollection 2018

  • 5. Sotiropoulos G, Lang H, Liu C, Brokalaki E, Molmenti E, Broelsch C. Surgical Treatment of Pancreatic Metastases of Renal Cell Carcinoma. JOP. Journal of the Pancreas. 2005; 6(4): 339–343.

  • 6. Shaun Kian Hong C, Khoon Leong C. Metastatic Renal Cell Carcinoma to the Pancreas A Review. Arch Pathol Lab Med. 2016; 140(6): 598–602. doi: 10.5858/arpa.2015-0135-RS.

  • 7. Alves Ribeiro M, Petersen da Costa Ferreira C, de Lucia Hernani B,ArnaldoSzutan L,Galli Mortati M, Toledo Bueno Pereira F et al. Uncommon site of metastasis from renal cell carcinoma: Case report. Int J Surg Case Rep. 2019; 56: 45–48. doi: 10.1016/j.ijscr.2019.02.013PMid: 30849687PMCid: PMC6406048

  • 8. Hoshino Y, Shinozaki H,Kimura Y, Masugi Y, Ito H,Terauchi T et al. Pancreatic metastases from renal cell carcinoma: a case report and literature review of the clinical and radiological characteristics. World J SurgOncol. 2013; 11: 289. doi: 10.1186/1477-7819-11-289PMid: 24209713PMCid: PMC3835140

  • 9. Boscà Robledo A, Barber Millet S, Orbis Castellanos J, MontalváOrón E, SalomFuster J, De Juan BurgueñoM. Metastasis of the gallbladder in clear cell renal carcinoma. Oncol Lett. 2012; 3(5): 1136–1138. doi: 10.3892/ol.2012.616PMid: 22783406PMCid: PMC3389630

  • 10. Sand M, Bechara F, Kopp J, Krins N, Behringer D, Mann B. Gallbladder metastasis from renal cell carcinoma mimicking acute cholecystitis. Eur. J. Med. Res. 2009; 14: 90–92.

  • 11. Kassabian A, Stein J, Jabbour N, Parsa K, Skinner D, Parekh D et al. Renal cell carcinoma metastatic to the pancreas: a single-institution series and review of the literature. Urology. 2000; 56: 211–215.

  • 12. Ghavamian R, Klein KA, Stephens DH, Welch TJ, LeRoy AJ, Richardson RL et al. Renal cell carcinoma metastatic to the pancreas: clinical and radiological features. Mayo Clin. Proc. 2000; 75: 581–585.

  • 13. Wente MN, Kleeff J, Esposito I, Hartel M, Müller MW, Fröhlich BE et al. Renal cell metastasis into the pancreas: a single-center experience and overview of the literature. Pancreas.2005; 30: 218–222.

  • 14. Sellner F, Tykalsky N, De Santis M, Pont J, Klimpfinger M. Solitary and multiple isolated metastases of clear cell renal carcinoma to the pancreas: an indication for pancreatic surgery. Ann SurgOncol. 2006; 13: 75–85. 10.1245/ASO.2006.03.064.

  • 15. Lavu H, Yeo JC.Metastatic Renal Cell Carcinoma to the Pancreas. Gastroenterol Hepatol (N Y). 2011; 7(10): 699–700. PMid: 22298967 PMCid: PMC3265016

  • 16. Strobel O, Hackert T, Hartwig W, Bergmann F, Hinz U, Wente MN, et al. Survival data justifies resection for pancreatic metastases. Ann SurgOncol. 2009; 16(12): 3340–9. doi: 10.1245/s10434-009-0682

  • 17. Kalra S, Atkinson B, Matrana M, Matin S, Wood C, Karam J et all. Prognosis of patients with metastatic renal cell carcinoma and pancreatic metastases. BJU Int. 2015; 117(5): 761–765. doi. org/10.1111/bju.13185

OPEN ACCESS

Journal + Issues

Search