Epidemiological Study of Canine Mast Cell Tumours According to the Histological Malignancy Grade

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Abstract

The aim of the study was to identify significant relationships between the tumour malignancy grade and dogs’ age, breed, sex, size, and location of mast cell tumours (MCTs). MCTs accounted for 13.27% of all diagnosed canine skin tumours. The highest incidence was recorded among Boxers, Labrador Retrievers, American Staffordshire Terriers, and Golden Retrievers. Statistical analysis revealed significantly higher probability of occurrence of the grade I mast cell tumour in the French Bulldog in the head, neck, torso, and limb regions, the grade-II mast cell tumour in Boxer, Doberman, Dachshund, shepherds, and setters in the scrotal region, and the grade III mast cell tumour in Shar-Pei in the axilla region. In the group of the oldest dogs aged 11-16, there was higher risk of development of MCTs grade II and III. Young dogs (aged 2-3 and 4-6) were found to be more prone to development of MCTs grade I. There was no correlation between MCTs grade and dogs’ sex and size. To the authors’ knowledge this is the first report on statistical relationships between the degree of mast cell tumour malignancy and dogs’ phenotypic traits, age and tumour location. This analysis indicate predilections for development of the particular mast cell tumour malignancy degrees in certain dog breeds, age, and anatomical location

Artuković B, Medven L, Hohšteter M, Šoštarić-Zuckermann IC, Kurilj AG, Beck A, Huber D, Grabarević D, Severin K, Grabarević Z (2014) Prevalence of cutaneous mast cell sarcoma in dogs in Croatia. Vet Arhiv 84: 601-614.

Blackwood L, Murphy S, Buracco P, De Vos JP, De Fornel- Thibaud P, Hirschberger J, Kessler M, Pastor J, Ponce F, Savary-Bataille K, Argyle DJ (2012) European consensus document on mast cell tumours in dogs and cats. Vet Comp Oncol 10: e1-e29.

Bostock DE (1986) Neoplasms of the skin and subcutaneous tissues in dogs and cats. Br Vet J 142: 1-19.

Brznden LB, Eriksen T, Kristensen AT (2010) Mast cell tumours and other skin neoplasia in Danish dog - data from the Danish Veterinary Cancer Registry. Acta Vet Scand 52: 6.

Camus MS, Priest HL, Koehler JW, Driskell EA, Rakich PM, Ilha MR, Krimer PM (2016) Cytologic criteria for mast cell tumor grading in dogs with evaluation of clinical outcome. Vet Pathol 53: 1117-1123.

Dobson JM (2013) Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013: 941275.

Dobson JM, Samuel S, Milstein H, Rogers K, Wood JL (2002) Canine neoplasia in the UK: estimates of incidence rates from a population of insured dogs. J Small Anim Pract 43: 240-246.

Dobson JM, Scase TJ (2007) Advances in the diagnosis and management of cutaneous mast cell tumours in dogs. J Small Anim Pract 48: 424-431.

Govier SM (2003) Principles of treatment for mast cell tumors. Clin Tech Small Anim Pract 18: 103-106.

Grabarević Z, Spoljar JB, Kurilj AG, Sostarić-Zuckermann IC, Artuković B, Hohsteter M, Beck A, Dzaja P, Strmecki NM (2009) Mast cell tumor in dogs-incidence and histopathological characterization. Coll Antropol 33: 253-258.

Hendrick MJ, Mahaffey EA, Moore FM, Vos JH, Walder EJ (1998) Histological classification of the mesenchymal tumors of skin and soft tissues of domestic animals. 2nd series, vol II, Armed Forces Institute of Pathology, Washington, D.C., pp 5-63.

Jasik A, Reichert M (2009) Epidemiological analysis of canine skin tumors. Medycyna Wet 65: 848-853.

Kaldrymidou H, Leontides L, Koutinas AF, Saridomichelakis MN, Karayannopoulou M (2002) Prevalence, distribution and factors associated with the presence and the potential for malignancy of cutaneous neoplasms in 174 dogs admitted to a clinic in northern Greece. J Vet Med 49: 87-91.

Kessler M, Von Bombard D, Matis U (1997) Canine and feline mast cell tumors. Epidemiology, diagnosis and therapy. Kleintierpraxis 42: 361.

Kiupel M, Webster JD, Bailey KL, Best S, DeLay J, Detrisac CJ, Fitzgerald SD, Gamble D, Ginn PE, Goldschmidt MH, Hendrick MJ, Howerth EW, Janovitz EB, Langohr I, Lenz SD, Lipscomb TP, Miller MA, Misdorp W, Moroff S, Mullaney TP, Neyens I, O’Toole D, Ramos-Vara J, Scase TJ, Schulman FY, Sledge D, Smedley RC, Smith K, W Snyder P, Southorn E, Stedman NL, Steficek BA, Stromberg PC, Valli VE, Weisbrode SE, Yager J, Heller J, Miller R (2011) Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior. Vet Pathol 48: 147-155.

Leidinger EF, Freeman K, Kirtz G, Hooijberg EH, Sick K (2014) Breed related odds ratio and anatomic distribution of canine mast cell tumours in Austria. Retrospective study of cases in the years 2000-2010. Tierarztl Prax Ausg K Kleintiere Heimtiere 42: 367-373.

McNiel EA, Prink AL, O’Brien TD (2006) Evaluation of risk and clinical outcome of mast cell tumours in pug dogs. Vet Comp Oncol 4: 2-8.

Miller DM (1995) The occurrence of mast cell tumors in young Shar-Peis. J Vet Diagn Invest 7: 360-363.

Misdorp W (2004) Mast cells and canine mast cell tumours. A review. Vet Q 26: 156-169.

Murphy S, Sparkes AH, Brearley MJ, Smith KC, Blunden AS (2004) Relationships between the histological grade of cutaneous mast cell tumours in dogs, their survival and the efficacy of surgical resection. Vet Rec 154: 743-746.

O’Connell K, Thomson M (2013) Evaluation of prognostic indicators in dogs with multiple, simultaneously occurring cutaneous mast cell tumours: 63 cases. Vet Comp Oncol 11: 51-62.

Patnaik AK, Ehler WJ, MacEwen EG (1984) Canine cutaneous mast cell tumor: morphologic grading and survival time in 83 dogs. Vet Pathol 21: 469-474.

Peters JA (1969) Canine mastocytoma: excess risk as related to ancestry. J Natl Cancer Inst 42: 435-443.

Pionnier-Capitan M, Bemilli C, Bodu P, Ce´le´rier G, Ferrie´ JG, Fosse P, Garcia M, Vigne JD (2011) New evidence for Upper Palaeolithic small domestic dogs in South-Western Europe. J Archaeol Sci 38: 2123-2140.

Rothwell TL, Howlett CR, Middleton DJ, Griffiths DA, Duff BC (1987) Skin neoplasms of dogs in Sydney. Aust Vet J 64: 161-164.

Sailasuta A, Ketpun D, Piyaviriyakul P, Theerawatanasirikul S, Theewasutrakul P, Rungsipipat A (2014) The Relevance of CD117-Immunocytochemistry Staining Patterns to Mutational Exon-11 in c-kit Detected by PCR from Fine-Needle Aspirated Canine Mast Cell Tumor Cells. Vet Med Int 2014: 787498.

Sapierzyński R (2010) Practical oncology in dogs and cats, 1st ed., Elsevier Urban Partner, Wrocław.

Sfiligoi G, Rassnick KM, Scarlett JM, Northrup NC, Gieger TL (2005) Outcome of dogs with mast cell tumors in the inguinal or perineal region versus other cutaneous locations: 124 cases (1990-2001). J Am Vet Med Assoc 226: 1368-1374.

Shoop SJ, Marlow S, Church DB, English K, McGreevy PD, Stell AJ, Thomson PC, O’Neill DG, Brodbelt DC (2015) Prevalence and risk factors for mast cell tumours in dogs in England. Canine Genet Epidemiol 26: 1.

Śmiech A, Ślaska B, Surdyka M, Grzybowska-Szatkowska L, Łopuszyński W, Różańska D (2016) Identification of additional mitochondrial DNA mutations in canine mast cell tumours. Acta Vet Scand 58: 28.

Thamm DH, Vail DM (2001) Mast cell tumors, In: Withrow SJ, MacEwen EG (eds) Small Animal Clinical Oncology, 3rd ed., WB Saunders Company, Philadelphia, pp 261-282.

Villamil JA, Henry CJ, Bryan JN, Ellersieck M, Schultz L, Tyler JW, Hahn AW (2011) Identification of the most common cutaneous neoplasms in dogs and evaluation of breed and age distributions for selected neoplasms. J Am Vet Med Assoc 239: 960-965.

Wakshlag JJ, Rassnick KM, Malone EK, Struble AM, Vachhani P, Trump DL, Tian L (2011) Cross-sectional study to investigate the association between vitamin D status and cutaneous mast cell tumours in Labrador retrievers. Br J Nutr 106 (Suppl 1): S60-S63.

Warland J, Dobson J (2013) Breed predispositions in canine mast cell tumour: a single centre experience in the United Kingdom. Vet J 197: 496-498.

Welle MM, Bley CR, Howard J, Rufenacht S (2008) Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment. Vet Dermatol 19: 321-339.

White CR, Hohenhaus AE, Kelsey J, Procter-Gray E (2011) Cutaneous MCTs: associations with spay/neuter status, breed, body size, and phylogenetic cluster. J Am Anim Hosp Assoc 47: 210-216.

Zemke D, Yamini B, Yuzbasiyan-Gurkan V (2002) Mutations in the juxtamembrane domain of c-KIT are associated with higher grade mast cell tumors in dogs. Vet Pathol 39: 529-535.

Zinc MC, Farhoody P, Elser SE, Ruffini LD, Gibbons TA, Rieger RH (2014) Evaluation of the risk and age of onset of cancer and behavioral disorders in gonadectomized Vizslas. J Am Vet Med Assoc 244: 309-319.

Polish Journal of Veterinary Sciences

The Journal of Committee of Veterinary Sciences of Polish Academy of Sciences and University of Warmia and Mazury in Olsztyn

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