Detection of Brachyspina carriers within Polish Holstein-Friesian bulls

Open access


The aim of this paper was to verify the hypothesis whether carriers of genetic defect Brachyspina occur in the Polish Holstein-Friesian Cattle. PCR method was used to screen 78 Polish Holstein-Friesian bulls. Eight bulls were identified as heterozygotes for 3,3 kb deletion in the FANCI gene – the mutation causing Brachyspina defect. All carriers were sons of 3 sires: Cleitus Jabot, Sandy-Valley Bolton ET and Coyne-Farms Dorcy ET which were descendants of the US sire Sweet Haven Tradition (HOUSAM 1682485). Systematic screening of young bulls having in the pedigree Barchyspina carrier is necessary to prevent spreading of the recessive mutation in the dairy cattle population in Poland.

Agerholm JS, McEvoy F, Arnbjerg J (2006) Brachyspina syndrome in a Holstein calf. J Vet Diagn Invest 18: 418-422.

Agerholm JS, Peperkamp K (2007) Familial occurrence of Danish and Dutch cases of the bovine brachyspina syndrome. BMC Vet Res 3: 8.

Charlier C, Agerholm JS, Coppieters W, Karlskov-Mortensen P, Li W, de Jong G, Fasquelle C, Karim L, Cirera S, Cambisano N, Ahariz N, Mullaart E, Georges M, Fredholm M (2012) A Deletion in the Bovine FANCI Gene Compromises Fertility by Causing Fetal Death and Brachyspina. PloS One 7: e43085.

Czarnik U, Grzybowski G, Kamiński S, Prusak B, Zabolewicz T (2007) Effectiveness of a program aimed at the elimination of BLAD-carrier bulls from the Polish Holstein-Friesian cattle. J Appl Genet 48: 375-377.

Fang L, Li Y, Zhang Y, Sun D, Liu L, Zhang Y, Zhang S (2013) Identification of brachyspina syndrome carriers in Chinese Holstein cattle. J Vet Diagn Invest 25: 508-510

OMIA000151-9913. Online Mendelian Inheritance of Animals.

Ruść A, Hering D, Puckowska P, Barcewicz M, Kaminski S (2013) Screening of Polish Holstein-Friesian bulls towards eradication of Complex Vertebral Malformation (CVM) carriers. Pol J Vet Sci 16: 579-581

VanRaden PM, Olson KM, Null DJ, Hutchison JL (2011) Harmful recessive effects on fertility detected by absence of homozygous haplotypes. J Dairy Sci 94: 6153-6161

Polish Journal of Veterinary Sciences

The Journal of Committee of Veterinary Sciences of Polish Academy of Sciences and University of Warmia and Mazury in Olsztyn

Journal Information

IMPACT FACTOR 2016: 0.697
5-year IMPACT FACTOR: 0.773

CiteScore 2016: 0.73

SCImago Journal Rank (SJR) 2016: 0.315
Source Normalized Impact per Paper (SNIP) 2016: 0.486


All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 216 133 10
PDF Downloads 120 94 7