The influence of doxazosin, an α1-adrenergic receptor antagonist on the urinary bladder contractility in pigs

Open access

Abstract

In the present study influence of doxazosin on the porcine urinary bladder contractility has been examined. Immature pigs were treated for 30 days with: a) doxazosin (n = 5) per os at a dose of 0.1 mg/kg b.w. or b) placebo (n = 5; control group). Thereafter, animals were sacrificed and urinary bladder strips from the trigone were suspended in organ baths. The tension of the smooth musce was measured before and after exposition to acetylocholine (ACh; 10-5 - 10-3 M), norepinephrine (NE; 10-9 - 10-7 M) and 5-hydroxytryptamine (5-HT; 10-7 - 10-5 M). Both the ACh and 5-HT at the highest doses significantly increased the contractility in each group, but this response was weaker in doxazosin-treated animals. NE caused relaxation in both groups, but the effect was weaker in doxazosine-treated group. The results of our study have shown that long-term administration of doxazosin caused a desensitization of the detrusor smooth muscle for in vitro applied mediators of the autonomic nervous systems.

Cohen ML, Drey K (1989) Contractile responses in bladder body, bladder neck and prostate from rat, guinea pig and cat. J Pharmacol Exp Ther 248: 1063-1068.

Cohen SA, Parsons JK (2012) Combination pharmacological therapies for the management of benign prostatic hyperplasia. Drugs Aging 29: 275-284.

Eroglu M, Sezgin A, Semercioz A, Metin A, Kandirali E, Ali Onur M (2007) Contractile responses of rabbit bladder neck to adrenaline, acetylcholine and papaverine after doxazosin treatment. Int Urol Nephrol 39: 137-141.

Khan MA, Thompson CS, Dashwood MR, Mumtaz FH, Mikhailidis DP, Morgan RJ (2000) Doxazosin modifies serotonin-mediated rabbit urinary bladder contraction. Potential clinical relevance. Urol Res 28: 116-121.

Li B, Gao W, Dong C, Han X, Li S, Jia R, Xiao C (2012) Long-term safety, tolerability, and efficacy of α1-adrenergic blocker in young men with primary bladder neck obstruction: results from a single centre in China. Int Urol Nephrol 44: 711-716.

Lowe FC (2004) Role of the newer alpha, -adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia- related lower urinary tract symptoms. Clin Ther 26: 1701-1713

Polish Journal of Veterinary Sciences

The Journal of Committee of Veterinary Sciences of Polish Academy of Sciences and University of Warmia and Mazury in Olsztyn

Journal Information


IMPACT FACTOR 2016: 0.697
5-year IMPACT FACTOR: 0.773

CiteScore 2016: 0.73

SCImago Journal Rank (SJR) 2016: 0.315
Source Normalized Impact per Paper (SNIP) 2016: 0.486

Cited By

Metrics

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 127 104 6
PDF Downloads 79 74 5