A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by 103Pd seeds

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Abstract

103Pd seed is being used for prostate brachytherapy. Additionally, the dose enhancement effect of gold nanoparticles (GNP) has been reported in previous studies. The aim of this study was to characterize the dosimetric effect of gold nanoparticles in brachytherapy with a 103Pd source. Two brachytherapy seeds including 103 Pd source was simulated using MCNPX Monte Carlo code. The seeds’ models were validated by comparing the MC with reported results. Then, GNPs (10 nm in diameter) with a concentration of 7mg Au/g were simulated uniformly inside the prostate of a humanoid computational phantom. Additionally, the dose enhancement factor (DEF) of nanoparticles was calculated for both modeled brachytherapy seeds. A good agreement was found between the MC calculated and the reported dosimetric parameters. For both seeds, an average DEF of 23% was obtained in tumor volume for prostate brachytherapy. The application of GNPs in conjunction with 103Pd seed in brachytherapy can enhance the delivered dose to the tumor and consequently leads to better treatment outcome.

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  • [1] Yang R Wang J Zhang H. Dosimetric Comparison of Permanent Prostate Brachytherapy Plans Utilizing Cs-131 I-125 and Pd-103 Seeds. Cancer Biother Radiopharm. 2009;24(6):701-5.

  • [2] Ververs J Anscher M Rivard M Todor D. A Treatment Planning Feasibility Study for Prostate LDR Brachytherapy Treatments Using the New 103-Pd CivaString Source. Comparison with Clinical Cases Using the TheraSeed Model 200 103-Pd Source. Med Phys. 2013;40(6):310.

  • [3] Rivard MJ Reed JL DeWerd LA. 103Pd strings: Monte Carlo assessment of a new approach to brachytherapy source design. Med Phys 2014;41(1):011716.

  • [4] Chandran PR Thomas RT. Chapter 14 - Gold Nanoparticles in Cancer Drug Delivery. In: Ninan STG editor. Nanotechnology Applications for Tissue Engineering.Oxford: William Andrew Publishing; 2015; 221-37.

  • [5] Gilles M Brun E Sicard-Roselli C. Gold nanoparticles functionalization notably decreases radiosensitization through hydroxyl radical production under ionizing radiation. Colloids Surf B: Biointerfaces 2014;123:770-7.

  • [6] Xie WZ Friedland WF Li WB et al. Simulation on the molecular radiosensitization effect of gold nanoparticles in cells irradiated by x-rays. Phys Med Biol. 2015;60(16):6195-212.

  • [7] Yao XF Huang CF Chen XF et al. Chemical Radiosensitivity of DNA Induced by Gold Nanoparticles. J Biomed Nanotechnol. 2015;11(3):478-85.

  • [8] Alexis F Rhee JW Richie JP et al. New frontiers in nanotechnology for cancer treatment. Urologic Oncology: Seminars and Original Investigations. 2008;26(1):74-85.

  • [9] Gao Z Zhang L Sun Y. Nanotechnology applied to overcome tumor drug resistance. J Control Release 2012;162(1):45-55.

  • [10] Geso M. Nanoparticle augmented radiation treatment decreases cancer cell proliferation. Nanomedicine: Nanotechnology Biology and Medicine 2013;9(2):302-3.

  • [11] Joh DY Kao GD Murty S et al. Theranostic Gold Nanoparticles Modified for Durable Systemic Circulation Effectively and Safely Enhance the Radiation Therapy of Human Sarcoma Cells and Tumors. Transl Oncol. 2013;6(6):722-732.

  • [12] Nazir S Hussain T Ayub A et al. Nanomaterials in combating cancer: Therapeutic applications and developments. Nanomedicine: Nanotechnology Biology and Medicine. 2014;10(1):19-34.

  • [13] Bertrand N Wu J Xu X et al. Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology. Adv Drug Deliv Revi. 2014;6666:2-25.

  • [14] Brede C Labhasetwar V. Applications of Nanoparticles in the Detection and Treatment of Kidney Diseases. Adv Chronic Kidney Dis. 2013;20(6):454-65.

  • [15] Chatterjee DK Fong LS Zhang Y. Nanoparticles in photodynamic therapy: An emerging paradigm. Adv Drug Deliv Rev 2008;60(15):1627-37.

  • [16] Etame AB Diaz RJ O’Reilly MA et al. Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound. Nanomedicine: Nanotechnology Biology and Medicine. 2012;8(7):1133-42.

  • [17] Feng G Kong B Xing J Chen J. Enhancing multimodality functional and molecular imaging using glucose-coated gold nanoparticles. Clin Radiol. 2014;69(11):1105-11.

  • [18] Gaca S Reichert S Multhoff G et al. Targeting by cmHsp70.1-antibody coated and survivin miRNA plasmid loaded nanoparticles to radiosensitize glioblastoma cells. J Control Rel. 2013;28;172(1):201-6.

  • [19] Hong H Chen F Zhang Y Cai W. New radiotracers for imaging of vascular targets in angiogenesis-related diseases. Adv Drug Deliv Rev. 2014;76:2-20.

  • [20] Lin Y McMahon SJ Scarpelli M et al. Comparing gold nano-particle enhanced radiotherapy with protons megavoltage photons and kilovoltage photons: a Monte Carlo simulation. Phys Med Biol. 2014;59(24):7675-89.

  • [21] Asadi S Vaez-Zadeh M Vahidian M et al. Ocular brachytherapy dosimetry for 103Pd and 125I in the presence of gold nanoparticles: a Monte Carlo study. J Appl Clin Med Phys. 2016;17(3):90-99.

  • [22] Khosravi H Hashemi B Mahdavi SR Hejazi P. Effect of Gold Nanoparticles on Prostate Dose Distribution under Ir-192 Internal and 18 MV External Radiotherapy Procedures Using Gel Dosimetry and Monte Carlo Method. J Biomed Phys Eng. 2015;5(1):3-14.

  • [23] Sinha N Cifter G Sajo E et al. Brachytherapy application with in situ dose painting administered by gold nanoparticle eluters. Int J Radiat Oncol Biol Phys. 2015;91(2):385-92.

  • [24] Reed JL Rivard MJ Micka JA et al. Experimental and Monte Carlo dosimetric characterization of a 1 cm 103Pd brachytherapy source. Brachytherapy. 2014;13(6):657-67.

  • [25] P Saidi M Sadeghi M Enferadi G Aslani. Investigation of palladium-103 production and IR07-103Pd brachytherapy seed preparation. Ann Nucl Energy. 2011;38(1):2168-73.

  • [26] Butler WM Merrick GS. Focal prostate brachytherapy with 103Pd seeds. Phys Med. 2016;32(3):459-64.

  • [27] Li ZY Gao HB Deng XS et al. Preparation of 103Pd brachytherapy seeds by electroless plating of 103Pd onto carbon bars. Appl Radiat Isot. 2015;103:128-30.

  • [28] Saidi P Sadeghi M Shirazi A Tenreiro C. Dosimetric parameters of the new design 103Pd brachytherapy source based on Monte Carlo study. Phys Med. 2012;28(1):13-8.

  • [29] National Laboratory Report No. BNL.NCS-17541. Cross section Evaluation Working Group. ENDF/B-VI summary documentation (ENDF-201). December 2000: National Nuclear Data Center; 2000.

  • [30] Rivard MJ Coursey BM DeWerd LA et al. Update of AAPM task group No. 43 report: a revised AAPM protocol for brachytherapy dose calculations. Med Phys. 2004;31(3):633-74.

  • [31] Raisali G Ghonchehnazi MG Shokrani P Sadeghi M. Monte Carlo and experimental characterization of the first AMIRS 103Pd brachytherapy source. Appl Radiat Isot 2008;66(12):1856-60.

  • [32] Kim YJ Park JH Yun IH Kim YS. A prospective comparison of acute intestinal toxicity following whole pelvic versus small field intensity-modulated radiotherapy for prostate cancer. Onco Targets Ther. 2016;9:1319-25.

  • [33] Xie WZ Friedland WF Li WB et al. Simulation on the molecular radiosensitization effect of gold nanoparticles in cells irradiated by x-rays. Phys Med Biol 2015; 21;60(16):6195-212.

  • [34] Yang CJ Chithrani DB. Nuclear Targeting of Gold Nanoparticles for Improved Therapeutics. Curr Top Med Chem. 2016;16(3):271-80.

  • [35] Brun E Sanche L Sicard-Roselli C. Parameters governing gold nanoparticle X-ray radiosensitization of DNA in solution. Colloids Surf B Biointerfaces. 2009;7(1)2:128-34.

  • [36] Brun E Duchambon P Blouquit Y et al. Gold nanoparticles enhance the X-ray-induced degradation of human centrin 2 protein. Radiat Phys Chem. 2009;78(3):177-83.

  • [37] Feng G Kong B Xing J Chen J. Enhancing multimodality functional and molecular imaging using glucose-coated gold nanoparticles. Clin Radiol. 2014;69(11):1105-11.

  • [38] Ghorbani M Mehrpouyan M Davenport D Ahmadi Moghaddas T. Effect of photon energy spectrum on dosimetric parameters of brachytherapy sources. Radiol Oncol. 2016;50(2):238-46.

  • [39] Reynoso FJ Manohar N Krishnan S Cho SH. Design of an Yb-169 source optimized for gold nanoparticle-aided radiation therapy. Med Phys. 2014;41(10):101709.

  • [40] Sinha N Cifter G Sajo E et al. Brachytherapy application with in situ dose painting administered by gold nanoparticle eluters. Int J Radiat Oncol Biol Phys. 2015;91(2):385-92.

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