Goji Berry (Lycium barbarum): Composition and Health Effects – a Review

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Abstract

Goji berries contain many nutrients and bioactive compounds which allowed to classify them as superfruits. A short description of the fruits is presented together with cultivation requirements. The chemical composition of the berries and their health-promoting properties are described later in this literature review. Based on the available data, their potentially beneficial application in dietary prevention of diseases of affluence, such as diabetes, cardiovascular diseases and cancer, is elaborated. We also refer to the safety of Goji consumption in the context of ingredients potentially harmful for human health, allergic reactions and the interactions with other substances.

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  • 1. Adams M. Wiedenmann M. Tittel G. Bauer R. HPLC-MS trace analysis of atropine in Lycium berries. Phytochem. Anal. 2006 17 279–283.

  • 2. Ahmad S.R. Gokulakrishnan P. Giriprasad R. Yatoo M.A. Fruit based natural antioxidants in meat and meat products: a review. Crit. Rev. Food Sci. Nutr. 2015 55 1503–1513.

  • 3. Amagase H. Farnsworth N.R. A review of botanical characteristics phytochemistry clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji). Food Res. Int. 2011 44 1702–1717.

  • 4. Amagase H. Sun B. Borek C. Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults. Nutr. Res. 2009a 29 19–25.

  • 5. Amagase H. Sun B. Nance D. Immunomodulatory effects of a standardized Lycium barbarum fruit juice in Chinese older healthy human subjects. J. Med. Food. 2009b 12 1159–1165.

  • 6. Amani R. Gill T. Shiftworking nutrition and obesity: implications for workforce health-a systematic review. Asia Pac. J. Clin. Nutr. 2013 22 505–515.

  • 7. Astrup A. Kristensen M. Gregersen N.T. Belza A. Lorenzen J.K. Due A. Larsen T.M. Can bioactive foods affect obesity? Ann. N. Y. Acad. Sci. 2010 1190 25–41.

  • 8. Batcagan-Abueg A.P.M. Lee J.J.M. Chan P. Rebello S.A. Amarra M.S.V. Salt intakes and salt reduction initiatives in Southeast Asia: a review. Asia Pac. J. Clin. Nutr. 2013 22 490–504.

  • 9. Benzie I.F.F. Wachtel-Galor S. Herbal Medicine: Biomolecular and Clinical Aspects. 2011 2nd ed. Boca Raton FL: CRC Press.

  • 10. Bucheli P. Vidal K. Shen L. Gu Z. Goji berry effects on macular characteristics and plasma antioxidant levels. Optom. Vis. Sci. 2011 88 257–262.

  • 11. Carnés J. de Larramendi.CH. Ferrer A. Huertas A.J. López-Matas M.A. Pagán J.A. Peña M. Recently introduced foods as new allergenic sources: sensitisation to Goji berries (Lycium barbarum). Food Chem. 2013 137 130–135.

  • 12. Castro I.A. Barroso L.P. Sinnecker P. Functional foods for coronary heart disease risk reduction: a meta-analysis using a multivariate approach. Am. J. Clin. Nutr. 2005 82 32–40.

  • 13. Chen Z. Tan B.K.H. Chan S.H. Activation of T lymphocytes by polysaccharide-protein complex from Lycium barbarum L. Int. Immunopharmacol. 2008 8 1663–1671.

  • 14. Cheng D. Kong H. The effect of Lycium barbarum polysaccha-ride on alcohol-induced oxidative stress in rats. Molecules 2011 16 2542–2550.

  • 15. Chiu K. Zhou Y. Yeung S.C. Lok C.K.M. Chan O.O.C. Chang R.C.C. Chiu J.F. Up-regulation of crystallins is involved in the neuroprotective effect of wolfberry on survival of retinal ganglion cells in rat ocular hypertension model. J. Cell Biochem. 2010 110 311–320.

  • 16. Cho Y.H. Ahn S.C. Lee S.Y. Jeong D.W. Choi E.J. Kim Y.J. Lee J.G. Lee Y.H. Shin B.C. Effect of Korean red ginseng on insulin sensitivity in non-diabetic healthy overweight and obese adults. Asia Pac. J. Clin. Nutr. 2013 22 365–371.

  • 17. Cui B. Liu S. Lin X. Wang J. Li S. Wang Q. Li S. Effects of Lycium barbarum aqueous and ethanol extracts on high-fat-diet induced oxidative stress in rat liver tissue. Molecules 2011 16 9116–9128.

  • 18. Dominion Seed House [online]. GOJI (Lycium barbarum) [access: 19–12–2013]. Retrieved from [http://www.dominion-seed-house.com/upload/GOJI_AN.pdf].

  • 19. Donno D. Beccaro G.L. Mellano M.G. Cerutti A.K. Bounous G. Goji berry fruit (Lycium spp.): antioxidant compound fingerprint and bioactivity evaluation. J. Funct. Food. 2015 doi:10.1016/j.jff.2014.05.020.

  • 20. dos Reis B.A. Kosińska–Cagnazzo A. Schmitt R. Andlauer W. Fermentation of plant material – Effect on sugar content and stability of bioactive compounds. Pol. J. Food Nutr. Sci. 2014 64 235–241.

  • 21. Gan L. Zhang S.H. Liang Yang X. Bi Xu H. Immunomodulation and antitumor activity by a polysaccharide-protein complex from Lycium barbarum. Int. Immunopharmacol. 2004 4 563–569.

  • 22. Gan L. Zhang S.H. Liu Q. Xu H.B. A polysaccharide-protein complex from Lycium barbarum upregulates cytokine expression in human peripheral blood mononuclear cells. Eur. J. Pharmacol. 2003 471 217–222.

  • 23. Gramza-Michałowska A. Caffeine in tea Camellia sinensis – content absorption benefits and risks of consumption. J. Nutr. Health Aging 2014 18 143–149.

  • 24. Gramza-Michałowska A. Korczak J. Oxygen radical absorbance capacity of selected food products. Acta Sci. Pol. Technol. Aliment. 2013 12 175–180.

  • 25. Gramza-Michałowska A. Sidor A. Hęś M. Herb extract influence on the oxidative stability of selected lipids. J. Food Biochem. 2011 35 1723–1736.

  • 26. Gross M.P. [online]. Exotic Antioxidant Superfruits. Volume 2: Goji (“Wolfberry”) [access: 19–12–2013]. Retrieved from [http://www.gojitrees.com/BerryDoctorGoji-GeneralEbook0–07.pdf].

  • 27. Guiné R.P.F. Lima M.J.R. Barroca M.J. Functional components of Foods. 2010 in: Food Diet and Health. Past Present and Future Tendencies (ed. R.P.F. Guiné). Nova Science Publishers New York pp. 59–135.

  • 28. Guo D.J. Cheng H.L. Chan S.W. Yu P.H.F. Antioxidative activities and the total phenolic contents of tonic Chinese medicinal herbs. Inflammopharmacology 2008 16 201–207.

  • 29. Guowen C. Longjun J. Qiang F. Anti-hyperglycemic activity of a polysaccharide fraction from Lycium barbarum. Afr. J. Biomed. Res. 2010 13 55–59.

  • 30. Harsh M.L. Tropane alkaloids from Lycium barbarum Linn. in vivo and in vitro. Curr. Sci. 1989 58 817–818.

  • 31. Henning S.M. Zhang Y. Rontoyanni V.G. Huang J. Lee R. Trang A. Nuernberger G. Heber D. Variability in the antioxidant activity of dietary supplements from pomegranate milk thistle green tea grape seed goji and acai: effects of in vitro digestion. J. Agric. Food Chem. 2014 62 4313−4321.

  • 32. Hęś M. Jeżewska M. Szymandera–Buszka K. Gramza-Michałowska A. Effect of antioxidant additives on nutritive value of dried meat. Zyw. Nauka Technol. Jakosc. 2011 5 94–106.

  • 33. Hu C.K. Lee Y.J. Colitz C.M. Chang C.J. Lin C.T. The protective effects of Lycium barbarum and Chrysanthemum morifolum on diabetic retinopathies in rats. Vet. Ophthalmol. 2012 15 65–71.

  • 34. Huang L.J. Tian G.Y. Wang Z.F. Dong J.B. Wu M.P. Studies on the glycoconjugates and glycans from Lycium barbarum L in inhibiting low density lipoprotein (LDL) peroxidation. Acta Pharm. Sin. 2001 36 108–111.

  • 35. Inbaraj B.S. Lu H. Hung C.F. Wu W.B. Lin C.L. Chen B.H. Determination of carotenoids and their esters in fruits of Lycium barbarum Linnaeus by HPLC-DAD-APCI-MS. J. Pharm. Biomed. Anal. 2008 47 812–818.

  • 36. Jiang L. Preparation and antioxidant activity of Lycium barbarum oligosaccharides. Carbohydr. Polym. 2014 99 646–648.

  • 37. Kmiecik D. Korczak J. Rudzińska M. Gramza-Michałowska A. Hęś M. Kobus-Cisowska J. Stabilization of phytosterols by natural and synthetic antioxidants in high temperature conditions. Food Chem. 2015 173 966–971.

  • 38. Kris-Etherton P.M. Hecker K.D. Bonanome A. Coval S.M. Binkoski A.E. Hilpert K.F. Griel A.E. Etherton T.D. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am. J. Med. 2002 113 71S–88S.

  • 39. Lam A.Y. Elmer G.W. Mohutsky M.A. Possible interaction between warfarin and Lycium barbarum L. Ann. Pharmacother. 2001 35 1199–1201.

  • 40. Larramendi C.H. García-Abujeta J.L. Vicario S. García-Endrino A. López-Matas M.A. García-Sedeño M.D. Carnés J. Goji berries (Lycium barbarum): risk of allergic reactions in individuals with food allergy. J. Investig. Allergol. Clin. Immunol. 2012 22 345–350.

  • 41. Leung H. Hung A. Hui A.C.F. Chan T.Y.K. Warfarin overdose due to the possible effects of Lycium barbarum L. Food Chem. Toxicol. 2008 46 1860–1862.

  • 42. Li X. Ma Y. Liu X. Effect of the Lycium barbarum polysaccha-rides on age-related oxidative stress in aged mice. J. Ethnopharmacol. 2007 111 504–511.

  • 43. Li X. Zhou A. Evaluation of the antioxidant effects of polysaccharides extracted from Lycium barbarum. Med. Chem. Res. 2007 15 471–482.

  • 44. Li X.M. Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats. Int. J. Biol. Macromol. 2007 40 461–465.

  • 45. Lin C. Wang C. Chang S. Antioxidative activity of polysaccharide fractions isolated from Lycium barbarum Linnaeus. Int. J. Biol. Macromol. 2009 45 146–151.

  • 46. Liu R.H. Dietary bioactive compounds and their health implications. J. Food Sci. 2013 78 A18–25.

  • 47. Liu X.L. Sun J.Y. Li H.Y. Zhang L. Qian B.C. Extraction and isolation of active component for inhibiting PC3 cell proliferation in vitro from the fruit of Lycium barbarum L. J. Chinese Materia Medica 2000 25 481–483.

  • 48. Llorent-Martínez E.J. Fernández-de Córdova M.L. Ortega-Barrales P. Ruiz-Medina A. Characterization and comparison of the chemical composition of exotic superfoods. Microchem. J. 2013 110 444–451.

  • 49. Luo Q. Cai Y. Yan J. Sun M. Corke H. Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sci. 2004 76 137–149.

  • 50. Mao F. Xiao B. Jiang Z. Zhao J. Huang X. Guo J. Anticancer effect of Lycium barbarum polysaccharides on colon cancer cells involves G0/G1 phase arrest. Med. Oncol. 2011 28 121–126.

  • 51. Marczyński S. Piotrowski W. Clematis [online]. Encyclopaedia of vines [access: 07–12–2013]. Retrieved from [http://www.clematis.com.pl].

  • 52. Marrazzo G. Barbagallo I. Galvano F. Malaguarnera M. Gazzolo D. Frigiola A. D’Orazio N. Li Volti G. Role of dietary and endogenous antioxidants in diabetes. Crit. Rev. Food Sci. Nutr. 2014 54 1599–1616.

  • 53. Medina M.B. Determination of the total phenolics in juices and superfruits by a novel chemical method. J. Funct. Foods 2011 3 79–87.

  • 54. Meydani M. Hasan S.T. Dietary polyphenols and obesity. Nutrients 2010 2 737–751.

  • 55. Mikulic-Petkovsek M. Schmitzer V. Slatnar A. Stampar F. Veberic R. Composition of sugars organic acids and total phenolics in 25 wild or cultivated berry species. J. Food Sci. 2012 77 C1064–1070.

  • 56. Milner J.A. Molecular targets for bioactive food components. J. Nutr. 2004 134 2492S-2498.

  • 57. Ming M. Guanhua L. Zhanhai Y. Guang C. Xuan Z. Effect of the Lycium barbarum polysaccharides administration on blood lipid metabolism and oxidative stress of mice fed high-fat diet in vivo. Food Chem. 2009 113 872–877.

  • 58. Mocan A. Vlase L. Vodnar D.C. Bischin C. Hanganu D. Gheldiu A. Operan R. Silaghi-Dumitrescu R. Crisan G. Polyphenolic content antioxidant and antimicrobial activities of Lycium barbarum L. and Lycium chinense Mill. leaves. Molecules 2014 19 10056–10073.

  • 59. Möller N.P. Scholz-Ahrens K.E. Roos N. Schrezenmeir J. Bio-active peptides and proteins from foods: indication for health effects. Eur. J. Nutr. 2008 47 171–182.

  • 60. Monzón Ballarín S. López-Matas M.A. Sáenz Abad D. Pérez-Cinto N. Carnés J. Anaphylaxis associated with the ingestion of Goji berries (Lycium barbarum). J. Investig. Allergol. Clin. Immunol. 2011 21 567–570.

  • 61. Morimoto A. Ohno Y. Tatsumi Y. Mizuno S. Watanabe S. Effects of healthy dietary pattern and other lifestyle factors on incidence of diabetes in a rural Japanese population. Asia Pac. J. Clin. Nutr. 2012 21 601–608.

  • 62. Ni T. Wei G. Yin X. Liu X. Liu D. Neuroprotective effect of Lycium barbarum on retina of Royal College of Surgeons (RCS) rats: a preliminary study. Folia Neuropathol. 2013 2 158–163.

  • 63. Pai P. Habeeba P. Ullal S. Evaluation of hypolipidemic effects of Lycium barbarum (Goji Berry) in a murine model. J. Nat. Rem. 2013 13 4–8.

  • 64. Peaceful Valley Farm Supply [online]. Goji (Wolf) Berries. Planting and growing guide [access: 21–12–2013]. Retrieved from [http://www.groworganic.com/media/pdfs/goji-l.pdf].

  • 65. Peng X.M. Qi C.H. Tian G.Y. Zhang Y.X. Physico-chemical properties and bioactivities of a glycoconjugate LbGp5B from Lycium barbarum L. Chin. J. Chem. 2001 19 842–846.

  • 66. Peng Y. Ma C. Li Y. Leung K.S.Y. Jiang Z.H. Zhao Z. Quantification of zeaxanthin dipalmitate and total carotenoids in Lycium fruits (Fructus Lycii). Plant Foods Hum. Nutr. 2005 60 161–164.

  • 67. Potterat O. Goji (Lycium barbarum and Lycium chinense): Phytochemistry pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med. 2010 76 7–19.

  • 68. Reguła J. Gramza-Michałowska A. New cereal food products with the addition of dried shiitake mushroom (Lentinula edodes) as a source of selected nutrients. Ital. J. Food Sci. 2010 3 292–297.

  • 69. Reguła J. Gramza-Michałowska A. Nutritional value and glycemic index of cereal products with dried oyster mushroom (Pleurotus ostreatus) added. Żywność. Nauka Technologia Jakość 2013 5 119 – 128.

  • 70. Rivera C.A. Ferro C.L. Bursua A.J. Gerber B.S. Probable interaction between Lycium barbarum (Goji) and warfarin. Pharmacotherapy 2012 32 e50-e53.

  • 71. Saldanha G.L. Summary of comments received in response to the Federal Register notice defining bioactive food components. Federal Register 2004 69 55821–55822.

  • 72. Shan X. Zhou J Ma T. Chai Q. Lycium barbarum polysaccha-rides reduce exercise-induced oxidative stress. Int. J. Mol. Sci. 2011 12 1081–1088.

  • 73. Sharma R. Singh R.B. Bioactive foods and nutraceutical supplementation criteria in cardiovascular protection. Open Nutraceut. J. 2010 3 141–153.

  • 74. Shashirakhaa M.N. Mallikarjunaa S.E. Rajarathnama S. Status of bioactive compounds in foods with focus on fruits and vegetables. Crit. Rev. Food Sci. Nutr. 2015 55 1324–1339.

  • 75. Shen Z. Wang J. Li G. Effect of extract of Lycium barbarum L. on adult human retinal nerve cells. Chin. J. Ophthalmol. 2012 48 824–828.

  • 76. Sidor A. Gramza-Michałowska A. Advanced research on the antioxidant and health benefit of elderberry (Sambucus nigra) in food – a review. J. Funct. Foods 2015 doi:10.1016/j.jff2014.07.012 in press.

  • 77. Song M.K. Salam N.K. Roufogalis B.D. Huang T.H.W. Lycium barbarum (Goji Berry) extracts and its taurine component inhibit PPAR-γ-dependent gene transcription in human retinal pigment epithelial cells: Possible implications for diabetic retinopathy treatment. Biochem. Pharmacol. 2011 82 1209–1218.

  • 78. Sopher L. Lauren. (n.d.). Lycium barbarum L. climbers.lsa.umich.edu (11) 1–5. Retrieved from [http://climbers.lsa.umich.edu/wpcontent/uploads/2013/07/LycibarbSOLAFINAL.pdf].

  • 79. Srinath Reddy K. Katan M.B. Diet nutrition and the prevention of hypertension and cardiovascular diseases. Public Health Nutr. 2004 7 167-186.

  • 80. Tang L. Zhang Y. Jiang Y. Willard L. Ortiz E. Wark L. Medeiros D. Lin D. Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes. Exp. Biol. Med. 2011 236 1051–1063.

  • 81. Tang W.M. Chan E. Kwok C.Y. Lee Y.K. Wu J.H. Wan C.W. Chan S.W. A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit. Inflammopharmacology 2012 20 307–314.

  • 82. USDA U.S. Department of Agriculture Agricultural Research Service. 2010. Oxygen Radical Absorbance Capacity (ORAC) of Selected Foods Release 2. Nutrient Data Laboratory Home Page: http://www.ars.usda.gov/nutrientdata/orac

  • 83. Wang C.C. Chang S.C. Inbaraj B.S. Chen B.H. Isolation of carotenoids flavonoids and polysaccharides from Lycium barbarum L. and evaluation of antioxidant activity. Food Chem. 2010 120 184–192.

  • 84. Wu S. Ng L. Lin C. Antioxidant activities of some common ingredients of traditional Chinese medicine Angelica sinensisLycium barbarum and Poria cocos. Phytother. Res. 2004 18 1008–1012.

  • 85. Xiao J. Liong E. Ching Y. Chang R. Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation. J. Ethnopharmacol. 2012 139 462–470.

  • 86. Yu H. Wark L. Ji H. Willard L. Jaing Y. Han J. Lin D. Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice. Mol. Nutr. Food Res. 2013 57 1158–1169.

  • 87. Zhang M. Chen H. Huang J. Li Z. Zhu C. Zhang S. Effect of Lycium barbarum polysaccharide on human hepatoma QGY7703 cells: inhibition of proliferation and induction of apoptosis. Life Sci. 2005 76 2115–2124.

  • 88. Zhang Z. Liu X. Wu T. Liu J. Zhang X. Yang X. Wang Y. Selective suppression of cervical cancer Hela cells by 2-O-β-D-glucopyranosyl-L-ascorbic acid isolated from the fruit of Lycium barbarum L. Cell Biol. Toxicol. 2011a 27 107–121.

  • 89. Zhang Z. Liu X. Zhang X. Liu J. Hao Y. Comparative evaluation of the antioxidant effects of the natural vitamin C analog 2-O-β-D-glucopyranosyl-L-ascorbic acid isolated from Goji berry fruit. Arch. Pharm. Res. 2011b 34 801–810.

  • 90. Zhao R. Li Q. Xiao B. Effect of Lycium barbarum polysaccha-ride on the improvement of insulin resistance in NIDDM rats. Yakugaku zasshi.J. Pharmaceut. Soc. Jap. 2005 125 981–988.

  • 91. Zhong Y. Shahidi F. Naczk M. Phytochemicals and health benefits of goji berries. 2013 in: Dried Fruits: Phytochemicals and Health Effects 1st Edition (eds. C. Alasalvar F. Shahidi). Wiley-Blackwell Publisher Hoboken New Jersey pp. 133–144.

  • 92. Zhu C.P. Zhang S.H. Lycium barbarum polysaccharide inhibits the proliferation of HeLa cells by inducing apoptosis. J. Sci. Food. Agric. 2013 93 149–156.

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