An Inulin-Enriched Soy Drink and Its Lowering Effect on Oxidized Low Density Lipoproteins in Healthy Volunteers

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Abstract

Due to selection of appropriate ingredients and parameters, a microbiologically-safe drink enriched with soy protein isolate (SPI) and prebiotic dietary fiber inulin with high scores of acceptability was produced. The results of medical nutrition survey showed that on the 21 day of using drink the level of oxidized low density lipoproteins (LDL) significantly decreased while the other biochemical parameters of blood of healthy patients as compared to the control tests remained unchanged. As well there was no apparent impact on the intestinal microflora balance of recipients established.

1. Ascencio C., Torres N., Isoard-Acosta F., Gomez-Perez F.J., Hernandez-Pando R., Tovar A.R., Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats. J. Nutr., 2004, 134, 522–529.

2. Bazzoli D.L., Hill S., DiSilvestro R. A., Soy protein antioxidant actions in active, young adult women. Nutr. Res., 2002, 22, 807–815.

3. Betoret E., Betoret N., Carbonell J.V., Fito P., Effect of pressure homogenization on particle size and the functional properties of citrus juices. J. Food Eng., 2009, 92, 18–23.

4. Burris R.L., Ng H.P., Nagarajan S., Soy protein inhibits inflammation-induced VCAM-1 and inflammatory cytokine induction by inhibiting the NF-κB and AKT signaling pathway in apolipoprotein E-deficient mice. Eur. J. Nutr., 2014, 53, 135–148.

5. Causey J.L., Feirtag J.M., Gallaher D.D., Tungland B.C., Slavin J.L., Effects of dietary inulin on serum lipids, blood glucose and gastrointestinal environment in hypercholesterolemic men. Nutr. Res., 2000, 20, 191–201.

6. Chen C.Y., Bakhiet R.M., Hart V., Holtzman G., Isoflavones improve plasma homocysteine status and antioxidant defense system in healthy young men at rest but do not ameliorate oxidative stress induced by 80% VO2pk exercise. Ann. Nutr. Metab., 2005, 49, 33–41.

7. Commission Regulation (EC) No. 2073/2005 of 15 November 2005 on microbiological criteria for foodstuffs.

8. EFSA Scientific Opinion on the substantiation of a health claim related to isolated soy protein and reduction of blood LDL-cholesterol concentrations pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal, 2012, 10(2):2555, p. 17.

9. Gibson G.R., Dietary modulation of the human gut microflora using the prebiotics oligofructose and inulin. J. Nutr., 1999, 129, 1438S-1441.

10. Hoie L.H., Guldstrand M., Sjoholm A., Graubaum H.J., Gruenwald J., Zunft H.J., Lueder W., Cholesterol-lowering effects of a new isolated soy protein with high levels of nondenaturated protein in hypercholesterolemic patients. Adv. Ther., 2007, 24, 439–447.

11. ISO 4833–1:2013 Microbiology of the food chain – Horizontal method for the enumeration of microorganisms – Part 1: Colony count at 30 degrees C by the pour plate technique.

12. ISO 4832:2006 Microbiology of food and animal feeding stuffs – Horizontal method for the enumeration of coliforms – Colony-count technique.

13. ISO 16649–2:2001 Microbiology of food and animal feeding stuffs – Horizontal method for the enumeration of beta-glucuronidase-positive Escherichia coli – Part 2: Colony-count technique at 44 degrees C using 5-bromo-4-chloro-3-indolyl beta-D-glucuronide.

14. Kaminskas A., Abaravičius J.A., Liutkevičius A., Jablonskienė V., Valiūnienė J., Bagdonaitė L., Andrikonytė J., Hendrixson V., Sekmokienė D., Quality of yoghurt enriched by inulin and its influence on human metabolic syndrome. Vet. Med. Zoot., 2013, 64, 23–28.

15. Kleessen B., Schwarz S., Boehm A., Fuhrmann H., Richter A., Henle T., Krueger M., Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers. Brit. J. Nutr., 2007, 98, 540–549.

16. Kuntz M.G.F., Fiates G.M.R., TeIxeira E., Characteristics of prebiotic food products containing inulin. Brit. Food J., 2013, 115, 235–251.

17. Letexier D., Diraison F., Beylot M., Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans. Am. J. Clin. Nutr., 2003, 77, 559–564.

18. Lindeberg S., Food and western disease: health and nutrition from an evolutionary perspective. 2013, (2. Expending our perspective, pp. 8–29). Wiley-Blackwell, Kindle Edition, p. 368.

19. Paßlack N., Vahjen W., Zentek J., Dietary inulin affects the intestinal microbiota in sows and their suckling piglets. BMC Vet. Res., 2015, 11, 351.

20. Pang G.C., Xie J., Chen Q., Hu Z., How functional foods play critical roles in human health. Food Sci. Hum. Wellness, 2012, 1, 26–60.

21. Schaafsma G.J., The protein digestibility–corrected amino acid score. J. Nutr., 2000, 130, 1865–1867.

22. Stoyanova S., Geuns J., Hideg E., Van Den Ende W., The food additives inulin and stevioside counteract oxidative stress. Int. J. Food Sci. Nutr., 2011, 62, 207–214.

23. Thorp A.A., Howe P.R., Mori T.A., Coates A.M., Buckley J.D., Hodgson J., Mansour J., Meyer B.J., Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers. Am. J. Clin. Nutr., 2008, 88, 298–304.

24. Tsumura K., Saito T., Tsuge K., Ashida H., Kugimiya W., Inouye K., Functional properties of soy protein hydrolysates obtained by selective proteolysis. LWT-Food Sci. Tech., 2005, 38, 255–261.

25. Van den Ende W., Peshev D., De Gara L., Disease prevention by natural antioxidants and prebiotics as ROS scavengers in the gastro-intestinal tract. Trends Food Sci. Tech., 2011, 22, 689–697.

26. Waitzberg L.D., Alves Pereira C.C., Logullo L., Manzoni Jacintho T., Almeida D., Teixeira da Silva M.L., Matos de Miranda Torrinhas R.S., Microbiota benefits after inulin and partially hydrolyzed guar gum supplementation: a randomized clinical trial in constipated women. Nutr. Hosp., 2012, 27, 123–129.

27. WHO, Strategy on Diet, Physical Activity and Health, 2004. [http://apps.who.int/iris/bitstream/10665/43035/1/9241592222_eng.pdf?ua=1].

28. Xiao C.W., Health effects of soy protein and isoflavones in humans. J. Nutr., 2008, 138, 1245s-1249s.

29. Zhan S., Ho S.C., Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. Am. J. Clin. Nutr., 2005, 81, 397–408.

Polish Journal of Food and Nutrition Sciences

The Journal of Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn

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