Nutritive And Dietetic Value Of Genetically-Modified Tomatoes Expressing Thaumatin Gene

Open access

Abstract

Genetically-modified (GM) tomatoes, carrying thaumatin gene encoding sweet-tasting protein may be a component of diet with high sensory values, constituting a valuable source of nutrients and substances with a health-promoting role. Good utilization and a lack of the effect on animal growth, value of hematological parameters, concentration of immunoglobulins and most of chemical blood parameters of laboratory rats were demonstrated in the nutritional studies on fruits of tomato GM plants. The biological response of the rats receiving GMO or its isogenic equivalent in the diet was recognized as similar. However, the unfavourable effect of the diets containing addition of tomatoes with the recombined thaumatin on the degree of oxidative degradation of DNA of rats liver was recorded. At the same time, the discussed dietary component had no effect on values of the remaining parameters of the oxidative status of tissue of the above mentioned organ and its histological image

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Alshatwi A.A. Al Obaaid M.A. Al Sedairy S.A. Al-Assaf A.H. Zhang J.J. Lei K.Y. Tomato powder is more protective than lycopene supplement against lipid peroxidation in rats. Nutr. Res. 2010 30 66-73.

  • 2. AOAC Official Methods of Analysis of the Association of Official Analytical Chemists (15th ed.) 1996 Arlington USA.

  • 3. Bartoszewski G. Niedziela A. Szwacka M. Niemirowicz- -Szczytt K. Modification of tomato taste in transgenic plants carrying a thaumatin gene from Thaumatococcus daniellii Benth. Plant Breed. 2003 122 347-351.

  • 4. Benito S. Buxaderas S. Mitjavila M.T. Flavonoid metabolites and susceptibility of rat lipoproteins to oxidation. Am. J. Physiol.

  • Heart Circ. Physiol. 2004 287 H2819-H2824.

  • 5. Bose K.S. Agrawal B.K. Effect of lycopene from cooked tomatoes on serum antioxidant enzymes lipid peroxidation rate and lipid profile in coronary heart disease. Singapore Med. J. 2007 48 415-420.

  • 6. Butelli E. Titta L. Giorgio M. Mock H.P. Matros A. Peterek S. Schijlen E.G.W.M. Hall R.D. Bovy A.G. Luo J. Martin C. Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors. Nat. Biotechnol. 2008 26 1301-1308.

  • 7. Campbell J.K. Canene-Adams K. Lindshield B.L. Boileau T.W. Clinton S.K. Erdman J.W. Jr. Tomato phytochemicals and prostate cancer risk. J. Nutr. 2004 134 3486S-3492S.

  • 8. Chen L. Bowen P.E. Berzy D. Aryee F. Stacewicz-Saountzakis M. Rilej R.E. Diet modification affects DNA oxidative damage in healthy humans. Free Rad. Biol. Med. 1999 26 695-703.

  • 9. Cooke M.S. Evans M.D. Dizdaroglu M. Lunec J. Oxidative DNA damage: mechanisms mutation and disease. FASEB J. 2003 17 1195-1214.

  • 10. Davidovich-Rikanati R. Sitrit Y. Tadmor Y. Iijima Y. Bilenko N. Bar E. Carmona B. Fallik E. Dudai N. Simon J.E. Pichersky E. Lewinsohn E. Enrichment of tomato flavor by diversion of the early plastidial terpenoid pathway. Nature Biotech. 2007 25 899-901.

  • 11. Dobromilska R. Mikiciuk M. Gubarewicz K. Evaluation of cherry tomato yielding and fruit mineral composition after using of bio-algeen s-90 preparation. J. Elementol. 2008 13 491-499.

  • 12. Dragsted L.O. Daneshvar B. Vogel U. Autrup H.N. Wallin H. Risom L. Moller P. Molcka M. Hansen M. Poulsen H.E. Loft S. A sucrose-rich diet induces mutations in the rat colon. Cancer Res. 2002 62 4339-4345.

  • 13. Dybing E. Doe J. Groten J. Kleiner J. O’Brien J. Renwick A.G. Schlatter J. Steinberg P. Tritscher A. Walker R. Younes M. Hazard characterisation of chemicals in food and diet: dose response mechanisms and extrapolation issues. Food Chem. Toxicol. 2002 40 237-282.

  • 14. EFSA Guidance document of the scientific panel on Genetically Modified Organisms for the risk assessment of genetically modified plants and derived food and feed. EFSA J. 2004 99 (updated on 7.12.2005) 1-94.

  • 15. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP); Scientific Opinion on the Safety and Efficacy of thaumatin for all animal species. EFSA J. 2011 9(9) 2354-2364.

  • 16. Fanasca S. Colla G. Maiani G. Venneria E. Rouphael Y. Azzini E. Saccardo F. Changes in antioxidant content of tomato fruits in response to cultivar and nutrient solution composition.J. Agric. Food Chem. 2006 54 4319-4325.

  • 17. Foksinski M. Gackowski D. Rozalski R. Siomek A. Guz J. Szpila A. Dziaman T. Olinski R. Effects of basal level of antioxidants on oxidative DNA damage in humans. Eur. J. Nutr. 2007 46 174-180.

  • 18. Friedman M. Fitch T.E. Yokoyama W.E. Lowering of plasma LDL cholesterol in hamsters by the tomato glycoalkaloid tomatine.Food Chem. Toxicol. 2000 38 549-553.

  • 19. Gajewski M. Kamińska E. Wysocki Ł. Szczepanik Sz. Sygitowicz G. Wojciechowski M. Pachecka J. Maśliński S. The economy of oxygen in the body. Vet. Life 2005 80 380-386 (in Polish).

  • 20. Georgé S. Tourniaire F. Gautier H. Goupy P. Rock E. Caris- -Veyrat C. Changes in the contents of carotenoids phenolic compounds and vitamin C during technical processing and lyophilisation of red and yellow tomatoes. Food Chem. 2011 124 1603-1611.

  • 21. Giovannucci E. A review of epidemiologic studies of tomatoes lycopene and prostate cancer. Exp. Biol. Med. 2002 227 852-859.

  • 22. Guil-Guerrero J.L. Rebolloso-Fuentes M.M. Nutrient composition and antioxidant activity of eight tomato (Lycopersicon esculentum) varieties. J. Food Comp. Anal. 2009 22 123-129.

  • 23. Gundersen V. McCall D. Bechmann I.E. Comparison of major and trace element concentrations in Danish greenhouse tomatoes (Lycopersicon esculentum Cv. Aromata F1) cultivated in different substrates. J. Agric. Food Chem. 2001 49 3808-3815.

  • 24. Hagiwara A. Yoshino H. Sano M. Kawabe M. Tamano S. Sakaue K. Nakamura M. Tada M. Imaida K. Shirai T. Thirteen- week feeding study of thaumatin (a natural proteinaceous sweetener) sterilized by electron beam irradiation in Sprague- -Dawley rats. Food Chem. Toxicol. 2005 5 1297-1302.

  • 25. Halliwell B. Gutteridge J.M.C. Lipid peroxidation: a radical chain reaction. 1989 in: Free Radicals in Biology and Medicine (2nd ed.). Clarendon Press Oxford pp. 139-189.

  • 26. Hallmann E. Rembiałkowska E. Estimation of fruits quality of selected tomato cultivars (Lycopersicon esculentum Mill) from organic and conventional cultivation with special consideration of bioactive compounds content. J. Res. Appl. Agric. Eng. 2007 52 55-60.

  • 27. Heber D. Lu Q.Y. Overview of mechanisms of action of lycopene. Exp. Biol. Med. 2002 227 920-923.

  • 28. Hernández M. Rull J. Rios D. Rodríguez E. Díaz C. Chemical composition of cultivar of tomatoes resistant and non resistant against the tomato yellow leaf curl virus (TYLCV). Electron.J. Environ. Agric. Food. Chem. 2005 4 1049-1054.

  • 29. Higginbotham J.D. Snodin D.J. Eaton K.K. Daniel J.W. Safety evaluation of thaumatin (Talin protein) Food Chem. Toxicol. 1983 21 815-823.

  • 30. INCHEM Thaumatin (WHO Food Additives Series 20) [http:// www.inchem.org/documents/jecfa/jecmono/v20je15.htm].

  • 31. JECFA Monograph: Toxicological evaluation of certain food additives and ontaminants. Thaumatin. 1987 WHO Food Additives Series No. 20. Cambridge University Press nos 605 on INCHEM [http://www.inchem.org/pages/jecfa.html].

  • 32. Kosieradzka I. Sawosz E. Pastuszewska B. Szwacka S. Malepszy S. Bielecki W. Czumińska K. The effect of feeding diets with genetically modified cucumbers on the growth and health status of rats. J. Anim. Feed Sci. 2001 10 7-12.

  • 33. Kosieradzka I. Sawosz E. Szopa J. Bielecki W. Potato genetically modified by 14-3-3 protein repression in growing rat diets.Part II.: health status of experimental animals. Pol. J. Food. Nutr.Sci. 2008 58 377-382.

  • 34. Kosieradzka I. Sawosz E. Winnicka A. Kluciński W. Malepszy S. Szwacka M. Pastuszewska B. The effect of transgenic cucumbers expressing thaumatin on selected immunity parameters in rats. J. Anim. Feed Sci. 2004 13 97-100.

  • 35. Kosieradzka I. Vasko V. Szwacka M. Przybysz A. Fiedorowicz Sz. Evaluation of the possibility of horizontal gene transfer and accumulation of transgenic DNA from diet in the bodies of experimental animals. J. Anim. Feed Sci. 2010 19 306-315.

  • 36. Martin C. Butelli E. Petroni K. Tonelli Ch. How can research on plants contribute to promoting human health? Plant Cell 2011 23 1685-1699.

  • 37. Moreno F.J. Gastrointestinal digestion of food allergens: Effect on their allergenicity. Biomed. Pharmacother. 2007 61 50-60.

  • 38. Neily M.H. Matsukura C. Maucourt M. Bernillon S. Deborde C. Moing A. Yin Y.G. Saito T. Mori K. Asamizu E. Rolin D. Moriguchi T. Ezura H. Enhanced polyamine accumulation alters carotenoid metabolism at the transcriptional level in tomato fruit over-expressing spermidine synthase. J. Plant. Physiol. 2011 168 242-252.

  • 39. NRC Nutrient Requirements of Laboratory Animals. 1996 National Research Council. (4th Ed.). Washington DC. National Academy of Sciences.

  • 40. Petr L. Erdman J.W. Lycopene and risk of cardiovascular disease. 2005 in: Carotenoids and Retinoids: Biological Actions and Human Health (eds. L. Packer L. U. Obermueller-Jevic K. Kramer Sies). AOCS Press Champaign IL pp. 204-217.

  • 41. Romer S. Fraser P.D. Kiano J.W. Shipton C.A. Misawa N. Schuch W. Bramley P.M. Elevation of the provitamin A content of transgenic tomato plants. Nat. Biotechnol. 2000 18 666-669.

  • 42. Saniewski M. Czapski J. The effect of methyl jasmonate on lycopene and beta-carotene accumulation in ripening red tomatoes.Experimentia 1983 39 1373-1374.

  • 43. Schijlen E.G. de Vos R. Jonker H. van den Broeck H. Molthoff J. van Tunen A. Martens S. Bovy A. Pathway engineering for healthy phytochemicals leading to the production of novel flavonoids in tomato fruit. Plant Biotech. J. 2006 4 433-444.

  • 44. Seroczyńska A. Niemirowicz-Szczytt K. Korzeniewska A. Utilization of three non-ripening mutants in tomato breeding for prolonged shelf life. Folia Horticulturae 1998 10 3-14.

  • 45. Sznajder M. Moskalik B. Wielicka A. Influence of age on customs of consumers in the range of fruits and vegetables consumption.The Polish Association of Agricultural and Agrobusiness Economists. Annals 2005 7(3) 173-178 (in Polish).

  • 46. Szwacka M. Krzymowska M. Osuch A. Kowalczyk M.E. Malepszy S. Variable properties of transgenic cucumber plants containing the thaumatin II gene from Thamatococcus daniellii. Acta Physiol. Plantarum 2001 24 173-185.

  • 47. Taylor S.L. Hefle S.L. Will genetically modified foods be allergenic? J. Allergy Clin. Immunol. 2001 107 765-771.

  • 48. Twardowska A. The application of transgenic cucumber containing thaumatin gene for direct consumption and food technology 2003 PhD Thesis Poznań University of Life Sciences Poland (in Polish) p. 134.

  • 49. Zhang C. Liu J. Zhang Y. Cai X. Gong P. Zhang J. Wang T. Li H. Ye Z. Overexpression of SlGMEs leads to ascorbate accumulation with enhanced oxidative stress cold and salt tolerance in tomato. Plant Cell Reports 2011 30 SI 389-398.

Search
Journal information
Impact Factor


IMPACT FACTOR 2017: 1.697
5-year IMPACT FACTOR: 1.760



CiteScore 2018: 1.92

SCImago Journal Rank (SJR) 2018: 0.621
Source Normalized Impact per Paper (SNIP) 2018: 0.908

Metrics
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 386 126 2
PDF Downloads 188 70 2