Health-Promoting Effects of Traditional Mediterranean Diets - A Review

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Health-Promoting Effects of Traditional Mediterranean Diets - A Review

Epidemiological studies have suggested that the adherence to Mediterranean diet (in Greek Mεσoγειακή Διατρoϕή, Mesogiaki diatrofi) is correlated to a low risk of cardiovascular diseases. Mediterranean diet offers a nutritional model enriched by diverse cultures which, over centuries, has essentially maintained the same structure. In general, this diet is rich in plant foods (fruit, vegetables, whole grain cereals, legumes, nuts), with moderate amounts of seafood, extra virgin olive oil as main dressing and regular, moderate red wine consumption at meals. Furthermore, it has been assumed that some bioactive constituents of Mediterranean foods are, at least in part, responsible for the observed health-promoting effects ascribed to this dietary style. Among these, polyphenols have been extensively studied for their biological activities, though hundreds of different secondary metabolites are present in plant foods. Therefore, it is plausible that additive and/or synergistic effects of phytochemicals may maximize the health potential of the traditional Mediterranean diet.

Abou-Agag L. H., Aikens M. L., Tabengwa E. M., Benza R. L., Shows S. R., Grenett H. E., Booyse F. M., Polyphenolics increase t-PA and u-PA gene transcription in cultured human endothelial cells. Alcohol. Clin. Exp. Res., 2001, 25, 155-162.

Afaq F., Katiyar S. K., Polyphenols: skin photoprotection and inhibition of photocarcinogenesis. Mini-Rev. Med. Chem., 2011, 11, 1200-1215.

Araim O., Ballantyne J., Waterhouse A. L., Sumpio B. E., Inhibition of vascular smooth muscle cell proliferation with red wine and red wine polyphenols. J. Vasc. Surg., 2002, 35, 1226-1232.

Corder R., Douthwaite J. A., Lees D. M., Khan N. Q., Viseu Dos Santos A. C., Wood E. G., Carrier M. J., Endothelin-1 synthesis reduced by red wine. Nature, 2001, 414, 863-864.

Csiszar A., Smith K., Labinsky N., Orosz Z., Rivera A., Ungvari Z., Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition. Am. J. Physiol-Heart C., 2006, 291, H1694-H1699.

Clifford M. N., Diet-derived phenols in plasma and tissues and their implication for health. Planta Med., 2004, 70, 1103-1114.

de la Puerta C., Carrascosa-Salmoral M. P., García-Luna P. P., Lardone P. J., Herrera J. L., Fernández-Montesinos R., Guerrero J. M., Pozo D., Melatonin is a phytochemical in olive oil. Food Chem., 2007, 104, 609-612.

de Lorgeril M., Salen P., The Mediterranean-style diet for the prevention of cardiovascular diseases. Public Health Nutr., 2006, 9, 118-123.

Fitó M., Guxens M., Corella D., Sáez G., Estruch R., de la Torre R., Francés F., Cabezas C., López-Sabater M. C., Marrugat J., Garcia-Arellano A., Aros F., Ruiz-Gutierrez V., Ros E., Salas-Salvado J., Fiol M., Sola R., Cova M. I., On behalf of the PREDIMED Study Investigators. Effect of a traditional Mediterranean diet on lipoprotein oxidation. A randomized, controlled trial. Arch. Intern. Med., 2007, 167, 1195-1203.

Garrido M., Paredes S. D., Cubero J., Lozano M., Toribio-Delgado A. F., Muñoz J. L., Reiter R. J., Barriga C., Rodríguez A. B., Jerte Valley cherry-enriched diets improve nocturnal rest and increase 6-sulfatoxymelatonin and total antioxidant capacity in the urine of middle-aged and elderly humans. J. Gerontol. Biol. Sci., 2010, 65A, 909-914.

Grigg D., Olive oil, the Mediterranean and the world. GeoJournal, 2001, 53, 163-172.

Hak A. E., Ma J., Powell C. B., Campos H., Gaziano J. M., Willet W. C., Stampfer M. J., Prospective study of plasma carotenoids and tocopherols in relation to risk of ischemic stroke. Stroke, 2004, 35, 1584-1588.

Hardeland R., Poeggeler B., Non-vertebrate melatonin. J. Pineal Res., 2003, 34, 233-241.

He K., Song Y., Daviglus M. L., Liu K., Van Horn L., Dyer A. R., Goldbourt U., Greenland P., Fish consumption and incidence of stroke: a meta-analysis of cohort studies. Stroke, 2004, 35, 1538-1542.

Hoffmann K., Zyriax B. C., Boeing H., Windler E., A dietary pattern derived to explain biomarker variation is strongly associated with the risk of coronary artery disease. Am. J. Clin. Nutr., 2004, 80, 633-640.

Hung H. C., Joshipura K. J., Jiang R., Hu F. B., Hunter D., Smith-Warner S. A., Colditz G. A., Rosner B., Spiegelman D., Willet W. C., Fruit and vegetable intake and risk of major chronic disease. J. Nat. Cancer Inst., 2004, 96, 1577-1584.

Iriti M., Faoro F., Plant defense & human nutrition: phenylpropanoids on the menu. Curr. Top. Nutraceutical Res., 2004, 2, 47-65.

Iriti M., Faoro F., Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. Int. J. Mol. Sci., 2009, 10, 3371-3399.

Iriti M., Varoni E. M., Vitalini S., Melatonin in traditional Mediterranean diets. J. Pineal Res., 2010, 49, 101-105.

Keys A., Seven Countries: a Multivariate Analysis of Death and Coronary Heart Disease. 1980, University of Harvard Press, Cambridge.

Lecour S., Lamont K. T., Natural polyphenols and cardioprotection. Mini-Rev. Med. Chem., 2011, 11, 1191-1199.

Lin B., Polyphenols and neuroprotection against ischemia and neurodegeneration. Mini-Rev. Med. Chem., 2011, 11, 1222-1238.

Maldonado M. D., Moreno H., Calvo J. R., Melatonin present in beer contributes to increase the levels of melatonin and antioxidant capacity of the human serum. Clin. Nutr., 2009, 28, 188-191.

Manach C., Williamson G., Morand C. Scalbert A, Remesy C., Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr., 2005, 81, 230S-242S.

Martinez J., Moreno J. J., Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production. Biochem. Pharmacol., 2000, 59, 865-870.

McGovern P. E., Ancient Wine: the Search for the Origins of Viniculture. 2003, University of Princeton Press, Princeton.

Mendoza E. E., Burd R., Quercetin as a systemic chemopreventative agent: structural and functional mechanisms. Mini-Rev. Med. Chem., 2011, 11, 1216-1221.

Naska A., Oikonomou E., Trichopoulou A., Psaltopoulou T., Trichopoulos D., Siesta in healthy adults and coronary mortality in the general population. Arch. Intern. Med., 2007, 167, 296-301.

Panagiotakos D. B., Arapi S., Pitsavos C., Antonoulas A., Mantas Y., Zombolos S., Stefanadis C., The relationship between adherence to the Mediterranean diet and the severity and short-term prognosis of acute coronary syndromes (ACS): The Greek Study of ACS (The GREECS). Nutrition, 2006, 22, 722-730.

Panagiotakos D. B., Chrysochou C., Sianos G., Zisimos K., Skoumas J., Pitsavos C., Stefanadis C., Sociodemographic and lifestyle statistics of oldest old people (>80 years) living in Ikaria Island: the Ikaria Study. Cardiol. Res. Pract., 2011, doi:10.4061/2011/679187.

Perez-Vizcaino F., Duarte J., Andriantsitohaina R., Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols. Free Radical Res., 2006, 40, 1054-1065.

Reiter R. J., Manchester L. C., Tan D.-X., Melatonin in walnuts: influence on levels of melatonin and total antoxidant capacity of blood. Nutrition, 2005, 21, 920-924.

Reiter R. J., Paredes S. D., Manchester L. C., Tan D.-X., Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin. Crit. Rev. Biochem. Mol. Biol., 2009, 44, 125-200.

Requena T., Monagas M., Pozo-Bayón M. A., Martín-Álvarez P. J., Bartolomé B., del Campo R., Ávila M., Martínez-Cuesta M. C., Peláez C., Moreno-Arribas M. V., Perspectives of the potential implications of wine polyphenols on human oral and gut microbiota. Trends Food Sci. Techn., 2010, 21, 332-344.

Scalbert A., Manach C., Morand C., Remesy C., Jimenez L., Diet ary polyphenols and the prevention of diseases. Crit. Rev. Food Sci. Nutr., 2005, 45, 287-306.

Scheepens A., Tan K., Paxton J. W., Improving the oral bioavailability of beneficial polyphenols through designed synergies. Genes Nutr., 2010, 5, 75-87.

Schreiner M., Vegetable crop management strategies to increase the quantity of phytochemicals. Eur. J. Nutr., 2005, 44, 85-94.

Shanmuganayagam D., Beahm M. R., Osman H. E., Krueger G. G., Reed J. D., Folts J. D., Grape seed and grape skin extracts elicit a greater anti-platelet effect when used in combination than when used individually in dogs and humans. J. Nutr., 2002, 132, 3592-3598.

Stein J. H., Keevil J. G., Wiebe D. A., Aeschlimann S., Folts J. D., Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation, 1999, 100, 1050-1055.

Trichopoulou A., Bamia C., Trichopoulos D., Anatomy of health effects of the Mediterranean diet: Greek EPIC prospective cohort study. Brit. Med. J., 2009, 338, b2337.

Vincent-Baudry S., Defoort C., Gerber M., Bernard M. C., Verger P., Helal O., Portugal H., Planells R., Grolier P., Amiot-Carlin M-J., Vague P., Lairon D., The Medi-RIVAGE study: reduction of cardiovascular disease risk factors after a 3-months intervention with a Mediterranean-type diet or a low-fat diet. Am. J. Clin. Nutr., 2005, 82, 964-971.

Visioli F., Davalos A., Polyphenols and cardiovascular disease: a critical summary of the evidence. Mini-Rev. Med. Chem., 2011, 11, 1186-1190.

Vitalini S., Gardana C., Zanzotto A., Fico G., Faoro F., Simonetti P., Iriti M., From vineyard to glass: agrochemicals enhance the melatonin and total polyphenol content and antiradical activity of red wines. J. Pineal Res., 2011a, 51, 278-285.

Vitalini S., Gardana C., Zanzotto A., Simonetti P., Faoro F., Fico G., Iriti M., The presence of melatonin in grapevine (Vitis vinifera L.) berry tissues. J. Pineal Res., 2011b, 51, 331-337.

Wallerath T., Deckert G., Ternes T., Anderson H., Li H., Witte K., Forstermann U., Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation, 2002, 106, 1652-1658.

Yang C. S., Sang S., Lambert J. D., Lee M.-J., Bioavailability issues in studying the health effects of plant polyphenolic compounds. Mol. Nutr. Food Res., 2008, 52, S139-S151.

Yusuf S., Hawkin S., Ounpuu S., Dans T., Avezum A., Lanas F., McQueen M., Budaj A., Pais P., Varigos J., Lisheng L., Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet, 2004, 364, 937-952.

Zern T. L., Wood R. J., Greene C., West K. L., Liu Y., Aggarwal D., Shachter N. S., Fernández M. L., Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J. Nutr., 2005, 135, 1911-1917.

Polish Journal of Food and Nutrition Sciences

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