Freeze-Drying - Application in Food Processing and Biotechnology - A Review

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Freeze-Drying - Application in Food Processing and Biotechnology - A Review

Freeze-drying is a method of removing water by sublimation of ice crystals from frozen material. Suitable parameters of process application allow us to obtain best quality products compared to products dried with traditional methods. Very good physical and chemical properties of food and biotechnological products make this method the best for drying exclusive products. On the domestic market there is a large selection of different types of freeze-dried products, and there is still increasing interest of consumers in these products. A high cost of the freeze-drying still limits the wide-scale application in the food industry. Equipment innovation and pretreatment of raw material can reduce the time and energy needed for this process.

Abdelwahed W., Degobert G., Stainmesse S., Fessi H., Freeze-drying of nanoparticles: Formulation, process and storage considerations. Adv. Drug Deliv. Rev., 2006, 58, 1688-1713.

Babic J., Cantalejo M. J., Arroqui C., The effect of freeze-drying process parameters on Broiler chicken breast meat. Food Sci. Technol., 2009, 42, 1325-1334.

Bird K., Palatability of freeze-dried meats. Food Technol., 1965, 19, 55.

Branger T., Bobin C., Iroulart M-G., Lepy M-C., Le Garreres I., Morelli S., Lacour D., Plagnard J., Comparative sturdy of two drying techniques used in radioactive source preparation: Freeze-drying and evaporation using hot dry nitrogen jets. Appl. Radiat. Isot., 2008, 66, 685-690.

Chan E. W. C., Lim Y. Y., Wong S. K., Lim K. K., Tan S. P., Lianto F. S., Yong M. Y., Effect of different drying methods on the antioxidant properties of leaves and tea of ginger species. Food Chem., 2009, 113, 166-172.

Chirife J., Buera M. P., A critical review of some nonequilibrium situations and glass transitions on water activity values of foods in the microbiological growth range. J. Food Eng., 1995, 25, 531-552.

Ciurzyńska A., Lenart A., Colour changes of freeze-dried strawberries osmotically dehydrated before drying. 2009, Food Technology Operations new vistas, pp. 217-223, Monograph.

Ciurzyńska A., Lenart A., Rehydration and sorption properties of osmotically pretreated freeze-dried strawberries. J. Food Eng., 2010, 97, 267-274.

Cui J. X., Li C. L., Deng Y. J., Wang Y. L., Wang W., Freeze-drying of liposomes using tertiary butyl alcohol/water cosolvent system. Int. J. Pharm., 2006, 312, 131-136.

De Sanoit J., Leprince B., Bobin Ch., Bouchard J., Freeze-drying applied to radioactive source preparation. Appl. Radiat. Isot., 2004, 61, 1391-1395.

Di Matteo P., Donsi G., Ferrari G., The role of heat and mass transfer phenomena in atmospheric freeze-drying of foods in a fluidised bed. J. Food Eng., 2003, 59, 267-275.

Dincer I., One energetic, exergetic and environmental aspects of drying systems. Int. J. Energy Res., 2002, 26, 717-727.

Dincer I., Refrigeration Systems and Applications. 2003, John Wiley & Sons, England, pp. 534-536.

Flink J. M., Energy analysis in dehydration processes. Food Technol., 1977, 31, 76-83.

Franks F., Freeze-dried blood: reality or confidence trick? Cryo-Letters, 1996, 17, 1.

Franks F., Freeze-drying of bioproducts: Putting principles into practice. Eur. J. Pharm. Biopharm., 1998, 45, 221-229.

Franks F., Freeze-drying/lyophilisation of pharmaceutical and biological products. Cryobiology, 2000, 40, 381-382.

Gawałek J., Effect of convection and freeze drying conditions on the quality of dried carrot roots. Inż. Roln., 2005, 71, 119-127 (in Polish).

George J. P., Datta A. K., Development and validation of heat and mass transfer models for freeze-drying of vegetables slices. J. Food Eng., 2002, 52, 89-93.

Hammami C., Rene F., Determination of freeze-drying process variables for strawberries. J. Food Eng., 1997, 32, 133-154.

Hammami C., Rene F., Marin M., Process-quality optimization of the vacuum freeze-drying of apple slices by the response surface method. Int. J. Food Sci. Technol., 1999, 34, 145-160.

Huang L., Zhang M., Wei-qiang Y., Mujumdar A. S., Sun D., Effect of coating on post-drying of freeze-dried strawberry pieces. J. Food Eng., 2009, 92, 107-111.

Jaekel T., Dautel K., Ternes W., Preserving functional properties of hen's egg yolk during freeze-drying. J. Food Eng., 2008, 87, 522-526.

Kreilgaard L., Frokjaer S., Flink J. M., Randolph T. W., Carpenter J. F., Effects of additives on the stability of recombinant human factor XIII during freeze-drying and storage in the dried solids. Arch. Biochem. Bioph., 1998, 360, 1, 121-134.

Krokida M. K., Tsami E., Maroulis Z. B., Kinetics on color changes during drying of some fruits and vegetables. Drying Technol., 1998, 16, 667-685.

Kusakabe H., Kamiguchi Y., Chromosomal integrity of freeze-dried mouse spermatozoa after 137Cs gamma-ray irradiation. Mutat. Res., 2004, 556, 163-168.

Lee S. M., Hwang T. R., Song Y. S., Lee J. W., Epoxy-phenolic novolac-montmorillonite hybrid nanocomposites: Novel synthesis methods and their characteristics. Polymer Eng. Sci., 2004, 44, 1170-1177.

Lewicki P. P., Lenart A., Osmotic dehydration of fruits and vegetables. 2007, in: Handbook of Industrial Drying. 3rd edit. (ed. Arun S. Mujumdar). Taylor & Francis Group, New York, pp. 665-688.

Lin Y-P. Tsen J-H., King A-E., Effect of far-infrared radiation on the freeze-drying of sweet potato. J. Food. Eng., 2005, 68, 249-255.

Liu Y., Zhao Y., Feng X., Exergy analysis for a freeze-drying process. Appl. Thermal Eng., 2008, 28, 675-690.

Long-yuan Li, Numerical simulation of mass transfer during the osmotic dehydration of biological tissues. Comp. Mater. Sci., 2006, 35, 75-83.

Marques L. G., Ferreira M. C., Freire J. T., Freeze-drying acerola (Malpighia glabra L.). Chem. Eng. Process., 2007, 46, 451-457.

Nowak D., Lewicki P. P., Infrared drying of apple slices. Inn. Food Sci. Emer. Technol., 2004, 5, 353-360.

Nsonzi F., Ramaswamy H. S., Osmotic dehydration kinetics of blueberries. Drying Technol., 1998, 16, 725-741.

Oesterle J., Frank F., Auffret T., The influence of tertiary butyl alcohol and volatile salts on the sublimation of ice from frozen sucrose solutions: implications for freeze-drying. Pharm. Dev. Technol., 1998, 3, 175-183.

Oguchi T., Yonemochi E., Yamamoto K., Freeze-drying of drugadditive binary system. IV. Effects of saccharide addition on the crystallization of cefazolin sodium in frozen aqueous solution. Pharm. Acta Helv., 1995, 70, 113-116.

Pacuła A., Bielańska E., Gaweł A., Baranowski K., Serwicka E. M., Textural effects in powdered montmorillonite induced by freeze-drying and ultrasound pretreatment. Appl. Clay Sci., 2006, 32, 64-72.

Palmfeldt J., Hahn-Hägerdal B., Influence of culture pH on survival of Lactobacillus reuteri subjected to freeze-drying. Int. J. Food Microbiol., 2000, 55, 235-238.

Pan Z., Shih C., McHugh T. H., Hirschberg E., Study of banana dehydration using sequential infrared radiation heating and freeze-drying. LWT-Food Sci. Technol., 2008, 41, 1944-1951.

Pikal M. J., Freeze-drying of proteins. Biopharmaceutics, 1991, 3, 18-29.

Ratti C., Hot air and freeze-drying of high-value foods: a review. J. Food Eng., 2001, 49, 311-319.

Rey L., May J., Freeze-drying/Lyophilization of pharmaceutical and biological products. Book reviews. Eur. J. Pharm. Biopharm., 2001, 51, 163-164.

Rindler V., Lüneberger S., Schwindke P., Heschel I., Rau G., Freeze-drying of red blood cells at ultra-low temperatures. Cryobiology, 1999, 38, 2-15.

Rindler V., Schwindke P., Heschel I., Rau G., Technical description of a low-temperature freeze-drying device. Int. J. Refrig., 1998, 7, 535-541

Sablani S. S., Rahman M. S., Al.-Kuseibi M. K., Al-Habsi N. A., Al-Belushi R. H., Al-Marhubi I., Al-Amri I. S., Influence of shelf temperature on pore formation in garlic during freeze-drying. J. Food Eng., 2007, 80, 68-79.

Sereno A. M., Hubinger M. D., Comesana J. F., Correa A., Prediction of water activity of osmotic solution. J. Food Eng., 2001, 49, 103-114.

Shahgaldian P., Gualbert J., Aissa K., Coleman A. W., A study of the freeze-drying conditions of calixarene based solid lipid nanoparticles. Eur. J. Pharm. Biopharm., 2003, 55, 181-184.

Shih C., Pan Z., Mc Hug, Wood D., Hirschberg E., Sequential infrared radiation and freeze-drying method for producing crispy strawberries. Trans. ASABE, 2008, 51, 205-216.

Stapelfeldt H., Nielsen B. R., Skibsted L. H., Effect of heat treatment, water activity and storage temperature on the oxidative stability of whole milk powder. Int. Dairy J., 1997, 7, 331-339.

Tsinontides S. C., Rajniak P., Pham D., Hunke W. A., Placek J., Reynolds S. D., Freeze drying-principles and practice for successful scale-up to manufacturing. Int. J. Pharm., 2004, 280, 1-16.

Tsuka H., Mori H., Okada K., Matsukawa S., Utilization of the freeze-drying method in the preparation of biologically active, intact RNA from hard frozen tissues of human prostate. Anal. Biochem., 1997, 247, 458-461.

Winkler M. M., Monaghan P., Gilbert J. L., Lautenschlager E. P., Freeze-drying and scanning electron microscopy of setting dental gypsum. Dent. Mater. J., 1995, 11, 226-230.

Witrowa-Rajchert D., Lewicki P. P., Rehydration properties of dried plant tissues. Int. J. Food Sci. Technol., 2006, 41, 1040-1046.

Yunfei L., Chengzhi W., The optimal parameters of freeze drying of food. 1996, in: Proc. of the 10th Int. Dry. Symp. (IDS '96), Krakow, Poland, 30 July-2 August 1996, Vol. B, pp. 801-804.

Zhai S., Taylor R., Sanches R., Slater N. K. H., Measurement of lyophilisation primary drying rates by freeze-drying microscopy. Chem. Eng. Sci., 2003, 58, 2313-2323.

Polish Journal of Food and Nutrition Sciences

The Journal of Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn

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