The Effect of Hyperbaric Oxygen Therapy On the Level of Lipid Peroxides in Rat Brains

Open access


The problem of oxygen toxicity, and its effect on the nervous system, is an important topic with regard to the application of oxygen and breathing mixes in the pursuit of diving, as well as in the light of the striking synergy between the effects of oxygen and ionising radiation. Studies on the level of lipid peroxides were performed on rat brains. The animals were subjected to exhaustive physical strain in a pressure chamber and oxygen at the pressure between 0-3 atm for the period of 25-60 minutes. Parallel research was conducted on rested animals. Following the dissection, the brain was homogenised and the levels of lipid peroxides were determined using the Wollman method with TBA. In animals subjected to physical effort over the specified time, no deviations in the levels of lipid peroxides were observed in comparison to the control group. An increase in lipid peroxide level was noted in rats manifesting oxygen toxicity symptoms. On the basis of the above findings, the authors presume that the growth of lipid peroxides in the brain in cases subjected to hyperbaric oxygenation should be recognised as a far-reaching harmful effect of oxygen, occurring after enzymatic damage and the violation of cellular antioxidant protection. At low oxygen overpressures, no deviations in the levels of lipid peroxides were noted as compared to the control group.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Becker N. Galvin J.: Acrospace Medloine. 1962 33 985-987;

  • 2. Beischer D:”Man’s dependence on the earthly atmosphere. Publ. The McMillan Comp. New York. 1962 166-186;

  • 3. Bieri J.: Progress in the Chemistry of Fats and other Lipids. Publ. Oxford 1964 v. 7: 2 247-266;

  • 4. Boerema J.: American Heart Jurnal. 1965 69 289-292;

  • 5. Dolatkowski A.: Collection of works published between1929-1957. D-wo Mar.Woj. Gdynia 1957;

  • 6. Fenn W.: Boll. Soc. Ital. Biol. Sperim. 1963 39 24 1703-1713;

  • 7. Froese G.: J. Appl. Physical. 1960 15 53-98;

  • 8. Gerschmun H.: Man’s dependence on the earthly atmosphere. Publ. The McMillan Comp. New York 1962 171-178.

  • 9. Guilford J.: Basic methods applied in psychology and pedagogy. PWN Warsaw 1960;

  • 10. Lambertson C. Kough R. Cooper D. Emmel G. Loeschoke M. Schmidt C.: J.Appl. Physiol. 1953 5 9 471-486;

  • 11. Płacer Z. Wiesielikowa A. Słabochowa E.: Woprosy Pitanja 1964 6 30-33;

  • 12. Sodlacek S.: Nahrung19582 655;

  • 13. Sjostedt S.: Biol. Neonatorum. 1964 6 1-2 1-7;

  • 14. Szczupakow W.: Profiłaktika i leczenie kessonnej bolezni. Medgiz 1962.

Journal information
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 164 81 3
PDF Downloads 102 58 1