The prognostic role of thrombophilia in the treatment of infertility

Túrós János Levente 1 , Kiss Szilárd-Leó 1 , Bereczky Lujza-Katalin 1 , Bartha Edina 3 , Lészai Lehel 2 , Szabó Tamás 2 , Györfi Imola 2 , and Szabó Béla 1
  • 1 University of Medicine and Pharmacy Târgu Mureş, 1st Department of Obstetrics and Gynecology
  • 2 Clinical Emergency Hospital of Târgu Mureş, 1st Department of Obstetrics and Gynecology
  • 3 Zygota Infertility Clinic,


Thrombophilia refers to a coagulation disorder that predisposes to thrombosis and thus increases the risk of thrombotic events. Both inherited and acquired thrombophilia are associated with vascular thrombosis and pregnancy-related complications, including infertility, recurrent miscarriage, and premature birth.

Recently, thrombophilia has been increasingly encountered as an infertility factor, which gives the clinical relevance of the disease.

The aim of the study was to investigate the prognostic role of thrombophilia in the treatment of infertility and the pregnancy of thrombophilic women during assisted reproduction procedures.

Frequency of abortions increases and effectiveness of in vitro fertilization (IVF) decreases with age. Normal weight has a positive effect on assisted reproduction techniques (ART’s) outcome. Repeat IVF failure is more common in thrombophilia than in healthy women, and the “take home baby” ratio for IVF is 24%. Spontaneous abortion was most commonly observed in the PAI homozygous group followed by MTHFR homozygous mutation, MTHFR heterozygous mutation, and Factor V (Leiden) mutation. The most effective treatment was concomitant therapy with low molecular weight heparin and aspirin.

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