The electrochemical behavior of an Fe(II)/Fe(III) redox couple in the presence of various selected amino acids has been studied using ferrocene-modified carbon paste electrode at pH = 7.4. Because of Fe(II)/Fe(III) solubility issues at physiological pH, ferrocene was used as a source of iron. Anodic oxidation of iron (pH = 7.2) occurred at 0.356 V and cathodic oxidation at 0.231 V, both vs Ag|AgCl. Treatment of the voltammetric data showed that it was a purely diffusion-controlled reaction with the involvement of one electron. After addition of amino acids, potential shifts and current changes can be observed on the voltammograms. Cyclic voltammetry experiments revealed the capability of amino acids to change the electrochemical behavior of the Fe(II)/Fe(III) redox couple.
If the inline PDF is not rendering correctly, you can download the PDF file here.
ARREGUIN S. NELSON P. PADWAY S. SHIRAZI M. PIERPONT C.: Dopamine complexes of iron in the etiology and pathogenesis of Parkinson’s disease. J. Inorg. Biochem. 103 2009 87-93.
BARD A. J. FAULKNER L. R.: Electrochemical methods: Fundamentals and applications. John Wiley & Sons New York 2001. 833 pp.
BOU-ABDALLAH F.: The iron redox and hydrolysis chemistry of the ferritins. Biochim. Biophys. Acta 1800 2010 719-731.
BRIDGEA M.H. WILLIAMSA E. LYONSB M.E.G. TIPTONC K.F. LINERT W.: Electrochemical investigation into the redox activity of Fe(II)/Fe(III) in the presence of nicotine and possible relations to neurodegenerative diseases. Biochim. Biophys. Acta 1690 2004 77-84.
GARCÍA C.R. ANGELÉ-MARTÍNEZ C. WILKES J.A. WANG H.C. BATTIN E.E. BRUMAGHIM J.L.: Prevention of iron- and copper-mediated DNA damage by catecholamine and amino acid neurotransmitters L-DOPA and curcumin: metal binding as a general antioxidant mechanism. Dalton Trans. 41 2012 6458-6467.
JAMESON G.N.L. LINERT W.: Iron release from horse-spleen ferritin by 6- hydroxydopamine : A kinetic study. J. Inorg. Biochem. 67 1997 164-164.
KAMYABI M.A. AGHAJANLOO F.: Electrocatalytic response of dopamine at a carbon paste electrode modified with ferrocene. Croat. Chem. Acta 82(3) 2009 599-606.
LLOYD R.V. HANNA P.M. MASON R.P.: The origin of the hydroxyl radical oxygen in the Fenton reaction. Free Rad. Biol. Med. 22 1997 885-888.
SAYRE L.M. PERRY G. HARRIS P.L.R. LIU Y. SCHUBERT K.A. SMITH M.A.: In Situ Oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer’s disease: a central role for bound transition metals. J. Neurochem. 74 2000 270-279.
SMITH M.A. HARRIS P.L.R. SAYRE L.M. PERRY G.: Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc. Natl. Acad. Sci. USA 94 1997 9866-9868.
ŠVANCARA I. KALCHER K. WALCARIUS A. VYTRAS K.: Electroanalysis with carbon paste electrodes CRC Press Boca Raton 2012 602 pp.
VALKO M. MORRI H. CRONIN M.T.D.: Metals Toxicity and Oxidative Stress. Curr. Medicinal Chem. 12 2005 1161-1208.
WATT G.D. FRANKEL R.B. PAPAEFTHYMIOU G.C.: Reduction of mammalian ferritin. Proc. Natl. Acad. Sci. USA 82 1985 3640-3643.
WINTERBOURN C.C.: Toxicity of iron and hydrogen peroxide: the Fenton reaction. Toxicol. Lett. 82/83 1995 969-974.
ZATTA P.: Metal ions and neurodegenerative disorders World Scientific Singapore 2003 511 pp.