Open access


In this paper the thermodynamic analyses were used to calculate the contributions of entropic and enthalpic terms of the binding processes of selected derivatives of alkoxy-substituted phenylcarbamic acid (MEP) and phenolic acids (PAs) on the series of molecularly imprinted polymers (MIPs) and corresponding non-imprinted polymers (NIPs). All polymers were prepared by a bulk polymerization method with different porogens and functional monomers. The thermodynamic assessments were based on the quantification by HPLC measurements of the analytes tested in different mobile phases and at temperature range from 293 K to 333 K. The thermodynamic parameters were determined from the van’t Hoff plots - dependences between logarithms of the retention factors of studied analytes (ln k) and the inverse value of the temperature (1/T). Almost all data showed that enthalpic term was the dominating driving force for the investigated analytes.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • BAGGIANI C. ANFOSSI L. GIOVANNOLI C.: MIP-based immunoassays: State of the art limitations and perspectives. Mol. Imprint. 1 2013 41 - 54.

  • CHEN J. XU G.R. BAI L.Y. TAO J.Z. LIU Y.Q. ZHANG Y.P.: A high sensitive sensor for terbuthylazine determination based on molecularly imprinted electropolymer of 3-Thiophenemalonic acid. J. Electrochem. Sci. 7 2012 9812 -9824.

  • CHESTER T.L. COYM J.W.: Effect of phase ratio on van't Hoff analysis in reversed-phase liquid chromatography and phase-ratio-independent estimation of transfer enthalpy. J. Chromatogr. A 1003 2003 101 - 111.

  • COYM J.W.: Comparison of retention on traditional alkyl polar endcapped and polar embedded group stationary phases. J. Sep. Sci. 31 2008 1712 - 1718.

  • HAIDACHER D. VAILAYA A. HORVÁTH C.: Temperature effects in hydrophobic interaction chromatography. PNAS 93 1996 2290 - 2295.

  • IRSHAD M. IQBAL N. MUJAHID A. AFZAL A. HUSSAIN T. SHARIF A. AHMAD E. ATHAR M.M.: Molecularly imprinted nanomaterials for sensor applications: Review. Nanomaterials 3 2013 615 - 637.

  • KIRSCH N. HEDIN-DAHLSTROM J. HENSCHEL H. WHITCOMBE M. J. WIKMAN S. NICHOLLS I.A.: Molecularly imprinted polymer catalysis of a Diels-Alder reaction. J. Mol. Catal. B: Enzym. 58 2009 110 - 117.

  • LI J. JIANG F. LI Y. CHEN Z.: Fabrication of an oxytetracycline molecularimprinted sensor based on the competition reaction via a GOD-enzymatic amplifier. Biosens. Bioelectron. 26 2011 2097 - 2101.

  • LUO Y. HUANG P. FU Q. DU W. SUN S. LI Y. LIU M. CHANG CH.: Preparation of monolithic imprinted stationary phase for clenbuterol by in situ polymerization and application in biological samples pretreatment.Chromatographia 74 2011 693 - 701.

  • SELLERGREN B.: Imprinted chiral stationary phases in high performance liquid chromatography. J Chromatogr. A 906 2001 227 - 252.

  • TONG K. XIAO S. LI S. WANG J.: Molecular recognition and catalysis by molecularly imprinted polymer catalysts: thermodynamic and kinetic surveys on the specific behaviors. J. Inorg. Organomet. Polym. 18 2008 426 - 433.

Journal information
Impact Factor

CiteScore 2018: 0.68

SCImago Journal Rank (SJR) 2018: 0.173
Source Normalized Impact per Paper (SNIP) 2018: 0.288

Cited By
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 133 44 0
PDF Downloads 74 39 1