Influence of Type 2 Diabetes and the Sex on the Occurrence of Sub-Clinic Left-Ventricular Diastolic Dysfunction of the Heart

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Abstract

Aims: To test the hypothesis that: the potential of type 2 diabetes, in precipitation of the sub clinical left ventricular diastolic dysfunction at the female sex, in absence of high blood pressure disease, coronary disease and other known heart disease, is different in comparison to the male sex.

Material and Methods: Prospectively, 180 people with type 2 diabetes were tested, at the ages between 45 and 55, divided into 2 groups: 1) Control group- was comprised of 60 patients (30 male and 30 female), without diabetes, with similar epidemiological-demographic characteristics; 2) Diabetes group - was comprised of 120 patients (60 women and 60 men) with type 2 diabetes. The estimation of the diastolic function of the left ventricular was made by Doppler echocardiograph analysis of the diastolic time intervals, as well as analysis of the model of ventricular filling, shown with a transmitral flow-velocity profile, acquired with a conventional pulsed-wave Doppler.

Results: Significant changes between the groups in clinical variables were observed regarding body mass index, low density cholesterol and triglycerides, the variables gotten with the pulsed-wave Doppler of the transmitral flow, and the duration of the isovolumetric relaxation time.

Conclusions: In this study, we do not prove the hypothesis that the type 2 diabetes potential in the precipitation of the sub clinical left ventricular diastolic dysfunction at the female sex, in absence of coronary disease, blood pressure disease and other well known heart diseases, is different in comparison to the male sex.

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