Study of Correlations Between Clinical Signs and Morphological Features Identified in Dogs Affected with Inflammatory Bowel Disease

Open access


This paper evaluates possible relations between the clinical activity and the histopathological findings of the entire intestine in dogs with inflammatory bowel disease (IBD). To perform this study, hospital records of 64 dogs of different sex and breed diagnosed with IBD were evaluated. The results of this study did not show a statistically significant correlation between clinical activity and the histopathological assessment of dogs with IBD. Certain connections were found between diarrhea and lacteal dilation in duodenum, and hematochezia and villous epithelial injury in colon but no other associations were found between the rest of the lesions and symptoms.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Jergens A.E. Schreiner C.A. Dagmar E.F. Yosiya N. Franklin E.A. Eckersall P.D. Benson T.J. Evans R.A. (2003). Scoring Index for disease activity in canine inflammatory bowel disease. J Vet Intern Med. 17 291-297. PMid:12774968

  • 2. Craven M. Simpson J.W. Ridyard A.E. Chandler M.L. (2004). Canine inflammatory bowel disease: retrospective analysis of diagnosis and outcome in 80 cases (1995-2002). J Small Anim Pract. 45 336-342. PMid:15266855

  • 3. Allenspach K. Steiner J.M. Shah B.N. Berghoff N. Ruaux C. Williams D.A. Blum J.W. Gaschen F. (2006). Evaluation of gastrointestinal permeability and mucosal absorptive capacity in dogs with chronic enteropathy. Am J Vet Res. 67 479-483. PMid:16506911

  • 4. Allenspach K. Wieland B. Gröne A. Gaschen F. (2007). Chronic enteropathies in dogs: evaluation of risk factors for negative outcome. J Vet Intern Med. 21 700-708. PMid:17708389

  • 5. Simpson K.W. Jergens A.E. (2011). Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease. Vet Clin Small Anim. 41 381-398. PMid:21486642

  • 6. Rychlik A. Nieradka R. Kander M. Nowicki M. Wdowiak M. Kolodziejska-Sawerska A. (2012). A correlation between the canine inflammatory bowel disease activity index score and the histopathological evaluation of the small intestinal mucosa in canine inflammatory bowel disease. Pol J Vet Sci. 15 315-321. PMid:22844710

  • 7. García-Sancho M. Rodríguez-Franco F. Sainz A. Mancho C. Rodríguez A. (2007). Evaluation of clinical macroscopic and histopahologic response to treatment in non hypoproteinemic dogs with limphocyticplasmacytic enteritis. J Vet Intern Med. 21 11-17. PMid:17338144

  • 8. Washabau R.J. Day M.J. Willard M.D. Hall E.J. Jergens A.E. Mansell J. Minami T. Bilzer T.W. (2010). Endoscopic biopsy and histopathologic guidelines for the evaluation of gastrointestinal inflammation in companion animals. ACVIM Consensus statement. J Vet Intern Med. 2410-26. PMid:20391635

  • 9. Jergens A.E. (2004). Clinical assessment of disease activity for canine inflammatory bowel disease. J Am Anim Hosp Assoc. 40 437-445. PMid:15533963

  • 10. Jergens A.E. Evans R.B. Ackerman M. Hostetter J. Willard M. Mansell J. et al. (2014). Design of a simplified histopathologic model for gastrointestinal inflammation in dogs. Vet Pathol. 51 (5): 946-950. PMid:24280943

  • 11. German A.J. Hall E.J. Day M.J. (2001). Immune cell populations within the duodenal mucosa of dogs with enteropathies. J Vet Intern Med. 15 14-25. PMid:11215906

  • 12. Münster M. Horauf A. Bilzer T. (2006). Assessment of disease severity and outcome of dieatary antibiotic and immunosuppressive interventions by use of the canine IBD activity index in 21 dogs with chronic inflammatory bowel disease. Berl Munch Tierarztl Wochenschr. 119 493-505.

  • 13. Day M.J. Bilzer T. Mansell J. Wilcock B. Hall E.J. Jergens A. et al. (2008). Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: a report from the world small animal veterinary association gastrointestinal standardization group. J Comp Path. 138 S1-S43.

  • 14. Allenspach K.A. Mochel J.P. Du Y. Priestnall S.L. Moore F. Slayter M. et al. (2019). Correlating gastrointestinal histopathologic changes to clinical disease activity in dogs with idiopathic inflammatory bowel disease. Vet Pathol. 56 435-443. PMid:30563436

  • 15. Willard M. Mansell J. (2011). Correlating clinical activity and histopathologic assessment of gastrointestinal lesion severity: current challenges. Vet Clin North Am Small Anim Pract. 41 457-463. PMid:21486647

  • 16. Willard M.D. Moore G.E. Denton B.D. Day M.J. Mansell J. Bilzer T. et al. (2010). Effect of tissue processing on assessment of endoscopic intestinal biopsies in dogs and cats. J Vet Intern Med. 24 84-89. PMid:20002551

  • 17. Pierce E.S. (2018). Could Mycobacterium avium subspecies paratuberculosis cause Crohn’s disease ulcerative colitis and colorectal cancer? Infect Agent Cancer. 13 1. PMid:29308085 PMCid:PMC5753485

  • 18. Heilmann R. M. Suchodolski J. S. (2015). Is inflammatory bowel disease in dogs and cats associated with a Th1 or Th2 polarization? Vet Immunol Immunopathol. 168(3-4): 131-134. PMid:26672910

  • 19. Prinsen C.A.C. Mokkink L.B. Bouter L.M. Alonso J. Patrick D.L. De Vet HC. et al. (2018). COSMIN guideline for systematic reviews of patient-reported outcome measures. Qual Life Res. 27(5): 1147-1157. PMid:29435801 PMCid:PMC5891568

Journal information
Impact Factor

CiteScore 2018: 0.45

SCImago Journal Rank (SJR) 2018: 0.193
Source Normalized Impact per Paper (SNIP) 2018: 0.328

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 12 12 12
PDF Downloads 10 10 10