Pharmacokinetics of Doxycycline in Ducks with Steatosis due to Force-feeding

Open access

Abstract

The pharmacokinetics of doxycycline was investigated in force-fed and normally fed ducks after single intravenous (i.v.) and oral (p.o.) administration at a dose of 15 mg/kg bw. Serum concentrations of the drug were determined by the HPLC method. Pharmacokinetic parameters were calculated using compartmental analysis. Serum concentrations of doxycycline after i.v. administration in both groups were not statistically different. The values of half-lives were 5.82±1.85 h and 6.06±5.51 h in normal and force-fed birds. The total body clearance was respectively 0.40±0.05 L/h/kg and 0.34±0.10 L/h/kg, and volume of distribution (Vss) was 2.80±0.85 L/kg and 2.18±0.89 L/kg. After p.o. administraton the maximum serum levels in the control group were 0.70±0.12 μg/mL and in force-fed birds were 1.93±0.32 μg/mL, measured at 2.95±0.60 h and 1.45±0.24 h, respectively. The values of absolute bioavailability were 18.89±6.48% and 37.58±13.63%. Longer doxycycline retention in force-fed ducks was registered. Our data can be accepted as an information for possible prolonged retention of doxycycline in force fed ducks compared to normally fed ones.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Pijpers A. Van Klingeren B. Schoevers E.J. Verheijden J.H.M. Van Miert A.S. (1989). In vitro activity of five tetracyclines and some other antimicrobial agents four porcine respiratory tract pathogens. J. Vet. Pharmacol. Ther. 12 267–276. http://dx.doi.org/10.1111/j.1365-2885.1989.tb00670.x PMid:2810475

  • 2. Anadón A. Martínez-Larra-aga M.R. Diaz M.J. Bringas P. Fernandez M.C. Fernandez-Cruz M.L. Iturbe J. Martínez M.A. (1994). Pharmacokinetics of doxycycline in broiler chickens. Avian Pathol. 23 79-90. http://dx.doi.org/10.1080/03079459408418976 PMid:18671073

  • 3. Poapolathep A. Poapolathep S. Imsilp K. Noonpugdee C. Klangkaew N. Kusujarit N. Tirawattanawanich C. Subsinsoonthon B. (2005). Pharmacokinetics and bioavailability of doxycycline in Thai native chickens. J. Thai. Vet. Med. Assoc. 56 59–65.

  • 4. Yang F. Li GH. Meng X.B. Wang L.Q. Huang X.H. Shan Q. Zeng D.P. Ding H.Z. Zeng Z.L. (2012). Pharmacokinetic interactions of flunixin meglumine and doxycycline in broiler chickens. J. Vet. Pharmacol. Ther. 36 85–88. http://dx.doi.org/10.1111/j.1365-2885.2012.01382.x PMid:22292913

  • 5. Küng K. Wanner M. (1994). Pharmacokinetics of Doxycycline in turkeys and comparison between feed and water medication. Archiv für Geflügelkunde 58 84–88.

  • 6. Santos M.D. Vermeersch H. Remon J. Schelkens M. Backer P. Van Bree H.J. Ducatelle R. Haesebrouck F. (1996). Pharmacokinetics and bioavailability of doxycycline in turkeys J. Vet. Pharmacol. Ther. 19 274–280. http://dx.doi.org/10.1111/j.1365-2885.1996.tb00049.x

  • 7. Yang F. Sun N. Zhao Z.S. Wang G.Y. Wang M.F. (2015). Pharmacokinetics of doxycycline after a single intravenous oral or intramuscular dose in Muscovy ducks (Cairina moschata). British Poultry Sci. 56 137–142. http://dx.doi.org/10.1080/00071668.2014.989488 PMid:25411077

  • 8. Dorrestein G. Weling J. Haagsma N. (1990). Pharmacokinetic differences for doxycycline between racing pigeon (Columba livia) and collared doves (Streptopelis decaocto) and the effect of a salmonella infection. In VII. Tagung der Fachgroupe „Geflugelkrankheiten“ (pp. 132–143) In Verbindung dem Institut für Geflugelkrankheiten der Ludvig-Maximilians-Universitet München Germany

  • 9. Bernard P.G. Bengone T Prehn D. Durand S. Labie C. Benard P. (2006). Physiology of ducks during force-feeding: study of hepatic steatosis. Bulletin de l‘Academie Vétérinaire de France 159 43–54.

  • 10. Bogin E. Avidar Y. Merom M. Israeli B. Malkinson M. Sobak S. Kudler Y. (1984). Biochemical changes associated whit fatty liver in geese. Avian Pathol. 13 683-901. http://dx.doi.org/10.1080/03079458408418566 PMid:18766879

  • 11. Awde S. Marty-Gasset N. Wilkesman J. Remingnon H. (2013). Proteolytic activity alterations resulting from force-feeding in Muscovy and Pekin ducks. Poultry Sci. 92 2997-3002. http://dx.doi.org/10.3382/ps.2013-03195 PMid:24135604

  • 12. Bratoev N. Lashev L. (2014). Pharmacokinetics of enrofloxacin in ducks with steatosis after force-feeding. VII-conference of the Bulgarian focal center of EFSA October 2014 Sofia Bugaria.

  • 13. Baert K. Croubels S. Gasthuys F. De Busser J. De Backer P. (2001). Pharmacokinetics and oral bioavailability of a doxycycline formulation (DOXYCYCLINE 75%) in nonfasted young pigs. J. Vet. Pharmacol. Ther. 23 45-48.

  • 14. El-Gendi A.Y.I. Aziza M.A. Amer M.M. Kamel G.M. (2010). Pharmacokinetic and tissue distribution of doxycycline in broiler chickens pre-treated with either: Diclazuril or Halofuginone. Food and Chem. Toxicol. 48 3209–3214. http://dx.doi.org/10.1016/j.fct.2010.08.024 PMid:20736042

  • 15. Yang F. Si HB. Wang Z.S. Zhao B. H. Zhou B. H. Hao X. Q. (2016). Pharmackinetics of doxycycline in laying hens after intravenous and oral administration. Britsh poultry sci. http://dx.doi.org/10.1080/00071668.2016.1184228 PMid:27137900

  • 16. Bengone-Ndong T. Benard G. Prehn D. Colas E. Grimm F. Benard P. (1996). Etude de la cinetique de la bromosulfonephthaleine et du vert d‘indocyanine chez le canard: determination de la linearite. Revue. Méd. Vét. 147 75-80.

  • 17. Slana M. Pahor V. Cvitkovič Maričič L Sollner-Dolenc M. (2014). Excretion pattern of enrofloxacin after oral treatment of chicken broilers. 37 611-614. http://dx.doi.org/10.1111/jvp.12130

  • 18. Buechler C Weiss T.S. (2011). Does hepatic steatosis affect drug metabolizing enzymes in the liver? Curr. Drug Metab. 12 24-34. http://dx.doi.org/10.2174/138920011794520035

  • 19. Liu Y. Ramamurthy N. Marecek J. Lee H.M. Chen J.L. Ryan M.E. Rifkin B.R. Golub L.M. (2001). The lipophilicity pharmacokinetics and cellular uptake of different chemically-modified tetracyclines (CMTs). Curr. Med. Chem. 8 243-252. http://dx.doi.org/10.2174/0929867013373525 PMid:11172678

  • 20. Mckellar Q. Sanchez Bruni A. S. F. Jones D. G. (2004) Pharmacokinetic/pharmacodynamic relationships of antimicrobial drugs used in veterinary medicine. J. Vet. Pharmacol. Therap. 27 503–514. http://dx.doi.org/10.1111/j.1365-2885.2004.00603.x PMid:15601444

Search
Journal information
Impact Factor


CiteScore 2018: 0.45

SCImago Journal Rank (SJR) 2018: 0.193
Source Normalized Impact per Paper (SNIP) 2018: 0.328

Cited By
Metrics
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 211 131 4
PDF Downloads 106 81 3