Correlation between endoscopic and histopathological findings in dogs with chronic gastritis

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Introduction: Chronic gastritis is a common diagnosis in dogs with signs of chronic vomiting. However, there is no data concerning endoscopic and histopathological agreement in dogs with chronic gastritis. Thus, a question should be raised whether taking gastroduodenal biopsies in dogs with chronic gastritis is necessary or not. Consequently, the purpose of the study was to compare the endoscopic and histopathological agreement in dogs with chronic gastritis. Material and Methods: A total of 22 non-pregnant client-owned dogs with the signs of chronic gastritis were enrolled in this prospective study. Procedures including clinical examination, blood analysis, and diagnostic imaging were performed before anaesthesia. Biopsies obtained from gastroduodenal sites were histopathologically evaluated. A total of 110 gastroduodenal samples were examined. Results: Sixtyeight samples had abnormal histopathology and endoscopy while 11 showed normal histopathological and endoscopic evidence. Conclusion: The obtained data demonstrated that it is not necessary to take extra gastroduodenal biopsies in dogs with evidence of endoscopic gastroduodenitis. We also believe that further prospective studies, including cost and time effectiveness and more specific comparison between endoscopic appearance and histopathology, are necessary to make final recommendations regarding the need of using both procedures for definitive diagnosis.

1. Atkins L., Benedict E.B.: Correlation of gross gastroscopic findings with gastroscopic biopsy in gastritis. N Engl J Med 1956, 254, 641-644.

2. Cotton P.B., Price A.B., Tighe J.R., Beales J.S.M.: Preliminary evaluation of “duodenitis” by endoscopy and biopsy. Br Med J 1973, 3, 430-433.

3. Dawson L., Baker J., Ala K., Shutt J., Jupp J., Bridger S.: Is taking histological biopsies in patients with gastritis a waste of time and money? Gut 2016, 65, 13-14.

4. Day M.J., Bilzer T., Mansell J., Wilcoc B., Hall E.J., Jergens A., Minami T., Willard M., Washabau R.: Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: a report from the world small animal veterinary association gastrointestinal standardization group. J Comp Path 2008, 138, 1-43.

5. Dunn J.K.: Textbook of small animal medicine. W.B. Saunders, London, 1999.

6. Eaton K.A., Dewhirst F.E., Paster B.J., Tzellas N., Coleman B.E.., Paola J., Sherding R.: Prevalence and varieties of Helicobacter species in dogs from random sources and pet dogs: animal and public health implications. J Clin Microbiol 1996, 34, 3165-3170.

7. Elta G.H., Appelman H.D, Behler E.M., Wilson J.A., Nostrant T.J.: A study of the correlation between endoscopic and histological diagnoses in gastroduodenitis. Am J Gastroenterol 1987, 82, 749-753.

8. Greenlaw R., Sheahan D.G., Deluca V., Miller D., Myerson D., Myerson P.: Gastroduodenitis. Digestive diseases and sciences 1980, 25, 660-672.

9. Guilford W.G.: Idiopathic inflammatory bowel disease. In: Strombeck’s Small Animal Gastroenterology, edited by D.R. Strombeck, W.B. Saunders, St. Louis, 1996, pp. 451-486.

10. Gwet K.: Handbook of Inter-Rater Reliability. Publishing Co, Gaithersburg, 2001.

11. Happonen I., Saari S., Castren L., Tyni O., Hänninen M.L., Westermarck E.: Occurrence and topographical mapping of gastric Helicobacter‐like organisms and their association with histological changes in apparently healthy dogs and cats. J Vet Med Series A 1996, 43, 305-315.

12. Hermanns W., Kregel K., Breuer W., Lechner J.: Helicobacterlike organisms: histopathological examination of gastric biopsies from dogs and cats. J Comp Pathol 1995, 112, 307-318.

13. Hwang C.Y., Han H.R., Youn H.Y.: Prevelance and clinical characterization of gastric Helicobacter species infection of dogs and cats in Korea. J Vet Sci 2002, 3, 123-133.

14. Ibis M., Arhan M., Odemis B.: The relation between endoscopically diagnosed gastritis and its histologic findings. Turk J Academic Gastroenterol (Akademik Gastroenteroloji) 2009, 8, 12-17.

15. Kono S., Gotoda T., Yoshida S., Oda I., Kondo H., Gatta L., Naylo G., Dixon M., Moriyasu F., Axon A.: Can endoscopic atrophy predict histological atrophy? Historical study in United Kingdom and Japan. World J Gastroenterol 2015, 21, 13113-13123.

16. Lidbury J.A., Suchodolski J.S., Steiner J.M.: Gastric histopathologic abnormalities in dogs: 67 cases (2002-2007). J Am Vet Med Assoc 2009, 234, 1147-1153.

17. Nakagawa S., Kato M., Shimizu Y.: Relationship between histopathologic gastritis and mucosal microvascularity: observations with magnifying endoscopy. Gastrointest Endosc 2003, 58, 71-75.

18. Robić M., Artuković B., Beck A., Gudan A., Svetina A., Grabarević Z.: Histopathological changes in stomachs of dogs with naturally acquired Helicobacter infection. Vet Arhiv 2007, 77, 103-111.

19. Shabestari A.S., Mohammadi M., Jamshidi S., Sasani F., Bahadori A., Oghalaie A.: Assessment of chronic gastritis in pet dogs and its relation with Helicobacter-like organisms. Pak J Biol Sci 2008, 11, 1443-1448.

20. Shanmugasamy K., Bhavani K., Narashiman R., Kotasthane D.S.: Clinical correlation of upper gastrointestinal endoscopic biopsies with histopathological findings and to study the histopathological profile of various neoplastic and non-neoplastic lesions. J Pharm Biomed Sci 2016, 6, 220-224.

21. Simpson K.W.: Gastric disease. In: Textbook of Veterinary Internal Medicine, edited by S.J. Ettinger, E.C. Feldman, W.B. Saunders, St. Louis, 2010, p. 1515.

22. Washabau R.J., Day M.J., Willard M.D., Hall E.J., Jergens A.E., Mansel J., Minami T., Bilzer T.W.: Endoscopic, biopsy, and histopathologic guidelines for the evaluation of gastrointestinal inflammation in companion animals. J Vet Intern Med 2010, 24, 10-26.

Journal of Veterinary Research

formerly Bulletin of the Veterinary Institute in Pulawy

Journal Information

IMPACT FACTOR Bull Vet Inst Pulawy 2017: 0.811

CiteScore 2016: 0.46

SCImago Journal Rank (SJR) 2017: 0.29
Source Normalized Impact per Paper (SNIP) 2015: 0.383


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