Investigation of human papillomaviruses (HPV), mouse mammary tumour virus (MMTV), Epstein–Barr virus (EBV), and human polyomavirus entities in canine mammary tumours

Kivilcim Sonmez 1 , Eda Altan 2 , Funda Yildirim 1 , Seçkin Serdar Arun 1 , Nuri Turan 2 , Huseyin Yilmaz 2 ,  and Mert Ahmet Kuskucu 3
  • 1 Pathology Department
  • 2 Virology Department, Veterinary Faculty, Istanbul University, 34320, Avcilar, Istanbul, Turkey
  • 3 Microbiology and Clinical Bacteriology Department, Cerraphasa Medicine Faculty, Istanbul University, 34098, Fatih, Istanbul, Turkey


Introduction: The aim of the study was to investigate the presence of human papillomaviruses (HPV), mouse mammary tumour virus (MMTV), Epstein-Barr virus (EBV), and human polyomavirus BK in canine mammary tumours (CMTs) and to correlate the results of histopathological classification with the results of virological examination. Material and Methods: Eighty CMTs and ten normal canine mammary gland samples were evaluated using histopathological methods and TaqMan real-time PCR analysis. Results: The results indicated that all mammary tumours and normal mammary tissue samples were negative for HPV16 and other HPV, EBV, human polyomavirus, and human mammary tumour virus strains. Conclusion: Further studies should be performed to investigate the existence of other strains of HPV, EBV, and human polyomavirus in CMTs.

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