Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) lead to a significant decrease in pulmonary function and quality of life and an increase in mortality. However, systemic use of corticosteroids is able to improve the conditions of patients in AECOPD. By a short review of several clinical trials, we suggest that 40 mg prednisone per day for 5 days should be recommended for the treatment of AECOPD with a preference for oral prednisolone.
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