Steroid pharmacokinetics: An “overlooked” issue of steroid metabolism in acute and chronic disease

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  • 1. Sefar S Degoricija V. About drug dialyzability. Acta Clin Croat 2003;42:257-26.

  • 2. Al-Habet SM Rogers HJ. Methylprednisolone pharmacokinetics after intravenous and oral administration. Br J Clin Pharmacol 1989;27:285-90.

  • 3. Venkatesh B Myburgh J Finfer S Webb SA Cohen J Bellomo R et al. The ADRENAL study protocol: Adjunctive corticosteroid treatment in critically ill patients with septic shock. Crit Care Resusc 2013;15:83-8.

  • 4. Frey BM Frey FJ. Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet 1990;19:126-46.

  • 5. Rohatagi S Barth J Möllmann H Hochhaus G Soldner A Möllmann C et al. Pharmacokinetics of methylprednisolone and prednisolone after single and multiple oral administration. J Clin Pharmacol 1997;37:916-25.

  • 6. Jusko WJ Milad MA Ludwig EA Lew KH Kohli RK. Methylprednisolone pharmacokinetics and pharmacodynamics in chronic renal failure. Clin Nephrol 1995;43 Suppl 1:S16-9.

  • 7. Straub RH Weidler C Demmel B Herrmann M Kees F Schmidt M et al. Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis 2004;63:961-8.

  • 8. Batzofin BM Sprung CL Weiss YG. The use of steroids in the treatment of severe sepsis and septic shock. Best Pract Res Clin Endocrinol Metab 2011;25:735-43.

  • 9. Toma A Stone A Green RS Gray S. Steroids for patients in septic shock: The results of the CORTICUS trial. CJEM 2011;13:273-6.

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