Association Between Vitamin D Deficiencies in Sarcoidosis with Disease Activity, Course of Disease and Stages of Lung Involvements

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Summary

Background: Despite negative association between 25-hydroxy vitamin D and incidence of many chronic respiratory diseases, this feature was not well studied in sarcoidosis. Current study investigated the association between 25-hydroxy vitamin D deficiency with sarcoidosis chronicity, disease activity, extra-pulmonary skin manifestations, urine calcium level and pulmonary function status in Iranian sarcoidosis patients. Results of this study along with future studies, will supply more effective programs for sarcoidosis treatment.

Methods: Eighty sarcoidosis patients in two groups of insufficient serum level and sufficient serum level of 25-hydroxy vitamin D were studied. Course of sarcoidosis was defined as acute and chronic sarcoidosis. Pulmonary function test (PFT) was assessed by spirometry. Skin involvements were defined as biopsy proven skin sarcoidosis. 24-hour urine calcium level was used to specify the disease activity. Stages of lung involvements were obtained by CT-scan and chest X-ray. The statistical analyses were evaluated using Statistical Package for the Social Sciences.

Results: A significant negative correlation was obtained between vitamin D deficiency in sarcoidosis patients and disease chronic course and stages two to four of lung involvements. Considering other parameters of the disease and vitamin D deficiency, no significant correlation was detected.

Conclusions: In conclusion, results of the current study implies in the role of vitamin 25(OH)D deficiencies in predicting the course of chronic sarcoidosis. Furthermore, it was concluded that vitamin 25(OH)D deficiency can direct pulmonary sarcoidosis toward stage 2–4 of lung involvements.

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  • 1. Mihailović-Vučinić V Ignjatović S Dudvarski-Ilić A Stjepanović M Vuković M Omčikus M et al. The role of vitamin D in multisystem sarcoidosis/Uloga vitamina D u sarkoidozi. Journal of Medical Biochemistry 2012; 31(4): 339–46.

  • 2. Eklund Daniel et al. »Vitamin D enhances IL-1 secretion and restricts growth of Mycobacterium tuberculosis in macrophages from TB patients.« International Journal of Mycobacteriology 2.1 (2013): 18–25.

  • 3. Sharma OP. Vitamin D and sarcoidosis. Current Opinion in Pulmonary Medicine 2010; 16(5): 487–8.

  • 4. Anderson J Harper C Dent C Philpot G. Effect of cortisone on calcium metabolism in sarcoidosis with hypercalcaemia: Possibly antagonistic actions of cortisone and vitamin D. The Lancet 1954; 264(6841): 720–4.

  • 5. Vucinic V Sumarac Z Vukovic M Stjepanovic M Omcikus M Videnovic J et al. 25(OH)D3 Vitamin Serum Levels Associated With Chronic Sarcoidosis. CHEST Journal 2011; 140(4_MeetingAbstracts): 617A-A.

  • 6. Black PN Scragg R. Relationship between serum 25- hydroxyvitamin d and pulmonary function in the third national health and nutrition examination survey. Chest Journal 2005; 128(6): 3792–8.

  • 7. Costabel U Teschler H. Biochemical changes in sarcoidosis. Clinics in Chest Medicine 1997; 18(4): 827–42.

  • 8. Kamphuis LS Bonte Mineur F van Laar JA van Hagen PM van Daele PL. Calcium and vitamin D in sarcoidosis: is supplementation safe? Journal of Bone and Mineral Research 2014; 29(11): 2498–503.

  • 9. Cowell G Reid J Simpson A Murchison J. Disorders of pulmonary circulation. Thrombosis J 2007; 46: 513–9.

  • 10. Costabel U Dubois R Eklund A James D Joneswilliams W Klech H et al. Consensus Conference-Activity Of Sarcoidosis 3rd Wasog Meeting Los-Angeles USA September 8–11 1993. Munksgaard Int Publ Ltd 35 Norre Sogade Po Box 2148 Dk-1016 Copenhagen Denmark; 1994.

  • 11. Adams JS Sharma O Gacad MA Singer FR. Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. Journal of Clinical Investigation 1983; 72(5): 1856.

  • 12. Nasiri MJ Varahram M Shams M Taghavi K Farnia P Velayati AA. Osteoarticular Tuberculosis in Iran 2002 to 2011. 2012.

  • 13. Swigris JJ Olson AL Huie TJ Fernandez-Perez ER Solomon J Sprunger D et al. Sarcoidosis-related mortality in the United States from 1988 to 2007. American Journal of Respiratory and Critical Care Medicine 2011; 183(11): 1524–30.

  • 14. Popević S Šumarac Z Jovanović D Babić D Stjepanović M Jovičić S Šobić-Šaranović D Filipović S Gvozdenović B Omčikus M Milovanović A Videnović-Ivanov J Radović A Žugić V Mihailović-Vučinić V. Verifying sarcoidosis activity: Chitotriosidase versus ACE in sarcoidosis – a case-control study. J Med Biochem 2016; 35: 390–400.

  • 15. Burke RR Rybicki BA Rao DS editors. Calcium and vitamin D in sarcoidosis: how to assess and manage. Seminars in Respiratory and Critical Care Medicine; 2010: © Thieme Medical Publishers.

  • 16. Sweiss NJ Lower EE Korsten P Niewold TB Favus MJ Baughman RP. Bone health issues in sarcoidosis. Current Rheumatology Reports 2011; 13(3): 265–72.

  • 17. Kennel KA Drake MT Hurley DL editors. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clinic Proceedings; 2010: Elsevier.

  • 18. Miller MR Hankinson J Brusasco V Burgos F Casaburi R Coates A et al. Standardisation of spirometry. European Respiratory Journal 2005; 26(2): 319–38.

  • 19. Mortaz E Masjedi M Abedini A Matroodi S Kiani A Soroush D et al. Common features of tuberculosis and sarcoidosis. International Journal of Mycobacteriology 2016; 5: S240–S241.

  • 20. Hasanain A Zayed A Mahdy R Nafee A. Cholecalciferol for prophylaxis against antituberculosis therapy-induced liver disorders among naïve patients with pulmonary tuberculosis: A randomized comparative study. The Inter national Journal of Mycobacteriology 2017; 6(2): 149.

  • 21. Katayoon Samadi AA Shahram Kharabian Lida Rezaian. Six-Minute Walking Test (6MWT) Results Assessment in Pulmonary Sarcoidosis Patients. Journal of Pulmonary & Respiratory Medicine 2016; 6: 3.

  • 22. Altman DG Gore SM Gardner MJ Pocock SJ. Statistical guidelines for contributors to medical journals. SAGE Publications Sage UK: London England; 1992.

  • 23. Mahmood A. Al-Azzawi Adel H. Ghoneim Ibrahim Elmadbouh. Evaluation of vitamin D vitamin D binding protein gene polymorphism with oxidant – antioxidant profiles in chronic obstructive pulmonary disease. J Med Biochem 2017; 36: 331–40.

  • 24. Salari M Rezaieyazdi Z. Prevalence and clinical picture of musculoskeletal sarcoidosis. Iranian Red Crescent Medical Journal 2014; 16(7).

  • 25. Sharma OP. Hypercalcemia in granulomatous disorders: a clinical review. Current Opinion in Pulmonary Medicine 2000; 6(5): 442–7.

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