Impact of Coexposure to Aluminum and Ethanol on Phosphoesterases and Transaminases of Rat Cerebrum

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Impact of Coexposure to Aluminum and Ethanol on Phosphoesterases and Transaminases of Rat Cerebrum

Ubiquitous presence along with uncontrolled use of aluminum and increasing trends of ethanol consumption in India increased the chance of coexposure to aluminum and ethanol. Possibilities are there, that both of them follow common mechanisms to produce neurotoxicity. The phosphomonoesterases and glutamate transaminases are studied in rat brain cerebrum after combined exposure to aluminum and varied doses of ethanol for 4 weeks. Dose dependent decreases in growth have been observed. The impact of aluminum on cerebral acidic and alkaline phosphomonoesterases activities were shown to be altered in a dose dependent fashion by the coexposure to ethanol. Aspartate aminotransferase and alanine aminotransferase of the cerebrum were responding differentially to aluminum exposure in the presence of different doses of ethanol exposure. It has been suggested that the ethanol-induced augmentation of impacts of aluminum on the cerebrum is dose dependent and there might be a critical level of ethanol exposure for the observed effect on cerebrum.

Nayak P. Aluminum: Impacts, Disease. Enviorn Res Sec A 2002; 89: 111-15.

Miu AC, Benga O. Aluminum, Alzheimer's disease: A new look. J Alzheimer Dis 2006; 10: 179-201.

Bihaqi SW, Sharma M, Singh AP, Tiwari M. Neuro-protective role of Covolvulus pluricaulis on aluminium induced neurotoxicity in rat brain. J Ethnopharmacol 2009; 124: 409-15.

Walton JR. Brain lesion comprised of aluminum-rich cells that lack microtubules may be associated with the cognitive deficit of Alzheimer's disease. Neurotoxicology 2009; 30: 1059-69.

WHO. Surveys of drinking patterns, problems in seven developing countries. WHO/MSD/MSB/ 01.2. 2001; p 103-114.

Benegal V Velayudhan A, Jain S. Social Costs of Alcoholism: A Karnataka Perspective. NIMHANS J 2000; 18: 67.

Dhatrak SV, Nandi SS. Risk assessment of chronic poisoning among Indian metallic miners. Ind J Occup Environ Med 2009; 13: 60-4.

Davis WM. Is aluminum an etiologic contributor to alcoholic amnesia, dementia? Med Hypotheses 1993; 41: 341-3.

Krewski D, Yokel RA, Nieboer E, Borchelt D, et al. Human health risk assessment for aluminium, aluminium oxide, aluminium hydroxide. J Toxicol Environ Health B Crit Rev 2007; 10 (Suppl 1): 1-269.

Nayak P, Chatterjee AK. Impact of protein malnutrition on subcellular nucleic acid, protein status of brain of aluminum-exposed rats. J Toxicol Sci 1998; 23: 1-14.

Nayak P, Chatterjee AK. Differential responses of certain brain phosphoesterases to aluminum in dietary protein adequacy or inadequacy. Food Chem Toxicol 2001; 39: 587-92.

Nayak P, Chatterjee AK. Response of regional brain glutamate transaminases of rat to aluminum in protein malnutrition. BMC Neurosci 2002; 3: 12.

Diamond I, Gordon AS. Cellular, molecular neuroscience of alcoholism. Physiol Rev 1997; 77: 1-20.

Rajasekaran K. Effects of combined exposure to aluminium, ethanol on food intake, motor behaviour, a few biochemical parameters in pubertal rats. Environ Toxicol Pharmacol 2000; 9: 25-30.

Das SK, Hiran KR, Mukherjee S, Vasudevan DM. Oxidative stress is the primary event: Effects of ethanol consumption in brain. Ind J Clin Biochem 2007; 22: 99-104.

Bharathi, Vadudevaraju P, Govindraju M, Plaanisamy AP, Sambamurti K, Rao KSJ. Molecular toxicity of aluminium in relation to neurodegeneration. Ind J Med Res 2008; 128: 545-56.

Strong MJ, Jakowec DM. 200kDa, 160kDa neurofilament protein phosphatase resistance following in vivo aluminum chloride exposure. Neurotoxicology 1994; 15: 799-808.

Ochmanski W, Barabasz W. Aluminum occurrence, toxicity for organisms. [Abstract from PubMed]. Przegl Lek 2000; 57: 665-8.

Sallam SMA, Nasser MEA, Yousef MSH, El-Morsy AM, Mahmoud SAS, Yousef MI. Influence of Aluminum Chloride, Ascorbic Acid on Performance, Digestibility, Caecal Microbial Activity, Biochemical Parameters of Rabbits. Res J Agri Biol Sci 2005; 1: 10-16.

Galle P. The toxicity of aluminum. World Scientist 1987; 13: 26-35.

Karlik SJ, Eichorn GL, Crapper McLachlan DR. Molecular interactions of aluminum with DNA. Neuro-toxicology 1980; 1: 83-8.

Dasgupta S, Ghosh S. Nicotine induced alterations in brain acid and alkaline phosphatase activities. Ind J Physiol Allied Sci 1993; 47: 200-6.

Laske V, Stein B, Muller A, Braunlich H, Fleck C, Linss W. The effect of chronic aluminum loading on lysosomal enzymes in serum and organ homogenates. Methodologic aspect. Pharmazie 1989; 44: 218-21.

Suzuki H, Takeda M, Nakamura Y, Tada k, Hariguchi S, Nishimura T. Activities of lysosomal enzymes in rabbit brain with experimental neurofibrillary changes. Neurosci Lett 1988; 89: 234-9.

Cohen S. Phosphatases. In: Lajtha A, editor. Handbook of Neurochemistry, Vol. III. Plenum Press, New York, 1970: 87-131.

Streecher HJ. Transaminases. In: Lajtha A, editor. Handbook of Neurochemistry, Vol III. Plenum Press, New York, 1970: 173-92.

Beal MF, Brovillet E, Jenkins B, Henshaw R, Rosen B, Hyman BT. Age-dependent striatal excitotoxic lesion produced by the endogenous mitochondrial inhibitor malanate. J Neurochem 1993; 61: 1147-50.

Schulz JB, Mathews RT, Henshaw DR, Beal MF. Neuro-protective strategies for treatment of lesions produced by mitochondrial toxins: implication for neurodegenerative diseases. Neuroscience 1996; 71: 1043-8.

Llansola M, Minana MD, Montoliu C, Saez R, Carbalan R, Manzo L, Felipo V. Prenatal exposure to aluminum reduces expression of neuronal nitric oxide synthase, soluble guanylate cyclase, impairs glutamatergic neuro-transmission in rat cerebellum. J Neurochem 1998; 73: 712-8.

Toninello A, Clari G, Mancon M, Tognon G, Zatta P. Aluminum as an inducer of the mitochondrial permeability transition. J Biol Inorg Chem 200; 5: 612-23.

Favarato M, Zatta PF. Differential aluminum lactate toxicity in rabbits using either aqueous solutions or liposomal suspensions. Toxicol Lett 1993; 66: 133-46.

Netopilova M, Haugvicova R, Kubova H, Drsata J, Mares P. Influence of convulsants on rat brain activities of alanine aminotransferase, aspartate aminotransferase. Neurochem Res 2001; 26: 1285-91.

Sedman GL, Austin L, Langford CJ. Protein turnover in brain during the development of alcohol dependence. Neurosci Lett 1982; 28: 93-9.

Jarlstedt J. Effect of alcohol and diet on 3H leucine incorporation into brain and liver protein. I. Acute intoxication and vitamin deficiency in rats. J Stud Alcohol 1976; 37: 1178-87.

Matthews CC, Zielke HR, Wollack JB, Fishman PS. Enzymatic degradation protects neurons from glutamate excitotoxicity. J Neurochem 2000; 75: 1045-52.

Moss DW, Henderson AR. Clinical enzymology. In: Burtis CA, Ashwood ER, editors. Teitz Textbook of Clinical Chemistry, Harcourt Brace, Company Asia Pvt. Ltd., Singapore. 1999: 617-721.

Santos F, Chan JC, Yang MS, Savory J, Wills MR. Aluminum deposition in the central nervous system: Preferential accumulation in the hippocampus in weaning rats. Med Biol 1987; 65: 53-5.

Journal of Medical Biochemistry

The Journal of Society of Medical Biochemists of Serbia

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