Psoriasis is a systemic chronic immune-mediated disorder, rarely reported in HIV-infected patients, in which the disease is more severe and debilitating. Response to treatment is modest, and skin diseases may profoundly affect the patients’ quality of life. Anti-psoriasis therapies have immunosuppressive effects and must be carefully recommended in HIV-infected patients. Moreover, the compliance of HIV patients diagnosed with psoriasis is low, and monitoring these patients is challenging. Herein we present a rare case of severe HIV-associated psoriasis with large plaques localized on the trunk, abdomen, limbs and plantar area in a non-compliant patient, with impaired renal and hepatic functions, dyslipidemia, and anemia, for whom the therapeutic approach was disappointing.
If the inline PDF is not rendering correctly, you can download the PDF file here.
1. Namazi MR. Paradoxical exacerbation of psoriasis in AIDS: proposed explanations including the potential roles of substance P and gramnegative bacteria. Autoimmunity. 2004;37:67-71.
2. Muñoz-Pérez MA Rodriguez-Pichardo A Camacho F Colmenero MA. Dermatological findings correlated with CD4 lymphocyte counts in a prospective 3 year study of 1161 patients with human immunodeficiency virus disease predominantly acquired through intravenous drug abuse. Br J Dermatol. 1998;139:33-39.
3. Arnett FC Reveille JD Duvic M. Psoriasis and psoriatic arthritis associated with human immunodeficiency virus infection. Rheum Dis Clin North Am. 1991;17:59-78.
4. Menon K Van Voorhees AS Bebo BF Jr et al. Psoriasis in patients with HIV infection: from the medical board of the National Psoriasis Foundation. J Am Acad Dermatol. 2010;62:291-299.
5. Morar N Willis-Owen SA Maurer T Bunker CB. HIV-associated psoriasis: pathogenesis clinical features and management. Lancet Infect Dis. 2010;10:470-478.
6. Borska L Andrys C Krejsek J et al. Oxidative damage to nucleic acids and benzo(a)pyrene-78-diol-910-epoxide-DNA adducts and chromosomal aberration in children with psoriasis repeatedly exposed to crude coal tar ointment and UV radiation. Oxid Med Cell Longev. 2014;302528.