Well-Differentiated Liposarcoma of The Larynx: A Case Report and Review of Literature

Open access


Liposarcoma is one of the most common soft tissue sarcomas in adults with a relative incidence amongst other sarcomas ranging from 9.8% to 16%. It usually locates in the limbs and retroperitoneum. Primary liposarcomas of the larynx and hypopharynx are rare, comprising less than 20% of all head and neck liposarcomas. According to World Health Organization, these tumors are divided into four histologic types, and well-differentiated liposarcoma is the most common one. It is a tumor of low-grade malignancy that may recur locally, but does not metastasize. We present a case of laryngopharyngeal well- differentiated liposarcoma in an old patient with two previous removals. We also discuss recently published cases with this unusual location of liposarcoma.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Weiss SW Goldblum JR. Liposarcoma. In: Weiss SW Goldblum JR editors. Enzinger and Weiss's soft tissue tumors. 5th ed. St. Louis: Mosby; 2007. p.641-65.

  • 2. Fletcher CDM Unni K.K Mertens F editors. World Health Organization classification of tumours. Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press; 2002.

  • 3. Barnes L Eveson LW Reichard P Sidransky D editors. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005.

  • 4. Sanz Gonzalo JJ P. Martinez Molina P Ribalta Farres MT Sabater Matadelabarata F. Liposarcoma of the hypopharynx. Acta Otorrinolaryngol Esp. 2002;53( 1): 60-3.

  • 5. Almela Cortis R Moreno Carazo A Martin Rodriguez L. Laryngeal and hypopharyngeal liposarcoma. Report of a case and literature review. An Otorrinolaringol Ibero Am. 2002;29(5):431-8.

  • 6. Perez Gonzalez R Martin Sigüenza G Alonso Orcajo N Casas Rubio C. Sarcoma of the larynx. Report of two cases. An Otorrinolaringol Ibero Am. 2003;30(3):301 -13.

  • 7. El Ouakif F Decourselle F Schultheis D. Li posarcoma of the hypopharynx: two case reports and literature review. Rev Laryngol Otol Rhinol (Bord). 2011; 132(4-5):245-50.

  • 8. Acharki A Sahraoui S Benider A Samlali R Kahlain A. Liposarcoma of the larynx. Review of the literature apropos of a case. Cancer Radiother. 1999;3(3):245-8.

  • 9. Steiger P Maurer R Honegger HP. Liposarcoma of the laryngeal region. Case report and literature review. Schweiz Med Wochenschr. 1992; 122(24):944-9.

  • 10. Miller D Goodman M Weber A Goldstein A. Primary liposarcoma ofthe larynx. Trans Am Acad Ophthalmol Otolaryngol. 1976;82:569-70.

  • 11. Shi H Wei L Wang H Sun L. Clinicopathological features of atypical lipomatous tumors of the laryngopharynx. J Zhejiang Univ Sci B. 2010;11(12):918-22.

  • 12. Mandell DL Brandwein MS Woo P Som PM Biller HF Urken ML.. Upper acrodigcstivc tract liposarcoma: report on four eases and literature rcvicw._Laryngoscopc. 1999;109(8): 1245-52.

  • 13.Wenig BM Heffner DK. Liposareomas of the larynx and hypopharynx: a clinicopathologic study of eight new eases and a review of the literature. Laryngoscope. 1995; 105(7 Pt 1):747-56.

  • 14. Wenig BM Weiss SW Gnepp DR. Laryngeal and hypopharyngeal liposarcoma. A clinicopathologic study of 10 eases with a comparison to soft-tissue counterparts. Am J Surg Pathol. 1990; 14(2): 134-41.

  • 15. Gleinser DM Font JP Clement CG Mohammed BS Underbrink MP. Primary myxoid liposarcoma of the supraglottic larynx. Rare Tumors. 2010;2(3): 112-4.

  • 16. Luna-Ortiz K Campos-Ramos E Carmona-Luna T Mohar-Betancourt A Fcrrari-Carballo T. Laser resection of liposarcoma of the hypopharynx. Med Oral Patol Oral Cir Bucal. 2009;14(5):E252-6.

  • 17. Makeief M PcUiccia P Poizat F Amaud S Rat F Cuppissol D ct al. Laryngeal dedifferentiated liposarcoma. Eur Arch Otorhinolaryngol. 2010; 267(6)391-4.

  • 18. Giordano G Corcionc L Gnetti L Mercante G Ferri T. Dedifferentiated liposarcoma of the pyriform sinus. Oral Oncol. 2006;42(4): 176-80.

  • 19. Gonzalez-Lois C Ibarrola C Ballestin C Martanez-Tello FJ. Dedifferentiated liposarcoma of the pyriform sinus: report of a ease and review of the literature. Int J Surg Pathol 2002; 10(1 ):75-9.

  • 20. Tobey DN Whcclis RF Yarington Jr CT. Electron microscopy in the diagnosis of liposarcoma and fibrosarcoma of the larynx. Arm Otol Rhinol Laryngol. 1979;88(Pt 1):867-71.

  • 21. McCormick D Mentzel T Beham A Fletcher CD. Dedifferentiated liposarcoma. Clinicopathologic analysis of 32 eases suggesting a better prognostic subgroup among pleomorphic sarcomas. Am J Surg Pathol. 1994; 18( 12): 1213-23.

  • 22. Muddaiah A Zaffarullah W Tewary A. Recurrent well-differentiated liposarcoma of the larynx: a ease report and review of literature. Eur Arch Otorhinolaryngol. 2010;267(7):1163-5.

  • 23. Mestre dc Juan MJ FcmGndcz-Accccro MJ. Laryngeal liposarcoma: report of a ease. Pathol Res Pract. 1999; 195(2): 125-8.

  • 24. Brauchle RW Farhood AI Pereira KD. Well-differentiated liposarcoma of the epiglottis. J Laryngol Otol. 2001; 115(7):593-5.

  • 25. Fahmy FF Osborne J Khalil HS Rodgers B. Well-differentiated liposarcoma of the hypopharynx. J Laryngol Otol. 1998;112(9):880-2.

  • 26. Powitzky R Powitzky ES Garcia R. Liposarcoma of the larynx. Ann Otol Rhinol Laryngol. 2007;116(6):418-24.

  • 27. Wambeek ND Mcndclson RM. Liposarcoma of the hypopharynx. Australas Radiol. 1996;40(2): 165-8.

  • 28. Mourct P. Liposarcoma of the hypopharynx. A ease report and review of the literature. Rev Laryngol Ftol Rhinol. 1999; 120( 1 ):39-42.

  • 29. Nouri H Hassani R Aderdour L Raji A. The well-differentiated liposarcoma of the hypopharynx. Eur Ann Otorhinolaryngol Head Neck Dis. 2011; 128(3):143-145.

  • 30. Sotirovic J Vukomanovic-Djurdjcvic B Balcdc N Paviccvic L Bijclic D Pcric A. Recurrent lipomatous tumor of hypopharynx: ease report and literature review. Acta Clin Croat. 2014; 53:365-368.

  • 31. Nishihoria T Aokia M Aokia K Yamadaa N Bunyaa K Mizutaa Kct al The surgical treatment for recurrent liposarcoma of the hypopharynx in a pregnant woman. J Med Cases. 2011 ;2(3): 127-31.

  • 32. Hurtado JF Lopez JJ Aranda FI Talavcra J. Primary liposarcoma of the larynx. Case report and literature review. Ann Otol Rhinol Laryngol. 1994;103(4):315-8.

  • 33. Reed JM Vick EG. Hypopharyngeal liposarcoma. Otolaryngol Head Neck Surg. 1996;114(3):499-500.

  • 34. Meis JM Mackay B Goepfert H. Liposarcoma of the larynx. Case report and literature review. Arch Otolaryngol Head Neck Surg. 1986;112(12): 1289-92.

  • 35. Allsbrook WC Jr Harmon JD Chongchitnant N Erwin S. Liposarcoma of the larynx. Arch Pathol Lab Med. 1985;109(3):294-6.

  • 36. Takano K Kondoh A Matsumiya H Himi T. A well-differentiated liposarcoma of the hypopharynx. Otolaryngol Head Neck Surg. 2011; 144(3):479-80.

  • 37. Miettinen M. Atypical lipomatous tumor and liposareomas. In: Miettinen M editor. Modem soft tissue pathology: tumors and non-ncoplasdc conditions. New York (NY): Cambridge University Press; 2010. p.432-60.

Journal information
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 221 75 2
PDF Downloads 88 35 1