Toxicological Chemical Analysis of Methanol in Blood of Patients with Acute Ethanol Intoxication for Determining Detectable Quantities of Methanol and Analysis of the Correlation Between Ingested Alcohol

Open access

Summary

The aim of the study was to carry out a toxicological chemical analysis of methanol in detectable quantities in the blood of patients with acute alcohol intoxication. Blood samples from 85 patients with acute alcohol intoxication were analysed for the presence of methanol. All patients with acute methanol intoxication were excluded from the study. The methods of gas chromatography with vapor-phase analysis (head-space) and flame ionization detection (FID) were used. The limit of detection (LOD=0.015 g/L) and the limit of quantification (LOQ=0.025 g/L) of methanol in whole blood were evaluated. In 30% of the cases, methanol was found in the blood in detectable quantities. The levels of methanol were on the average 5 to 6 times lower than the toxic methanol level (0200 g/L) and they were not due to natural metabolic processes (ingestion of fruit, fruit juices or vegetables). No reliable statistically linear correlation between the concentration of ethanol and methanol was found. Methanol subintoxications are major factors in alcohol intoxications, in which the quantity of the alcohol ingested is not as important as its quality. Chronic methanol subintoxication of people who often consume alcohol of poor quality is discussed.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. National Institute for Occupational Safety and Health (NIOSH): Methyl alcohol [Internet] Atlanta (GA): NIOSH; 1994 [updated 2014 Dec 4; cited 2015 Nov 15]. Available from: http://www.cdc.gov/niosh/idlh/67561.html.

  • 2. Seyffart G. Poyson index: The treatment of acute intoxication. Lengerich: Pabst Science; 1997.671 p.

  • 3. Barceloux DG Bond GR Krenzelok EP Cooper H Vale JA American Academy of Clinical Toxicology Ad Hoc Committee on the Treatment Guidelines for Methanol Poisoning. American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. J Toxicol Clin Toxicol. 2002;40(4):415-46.

  • 4. Schulz M Schmoldt A. Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Pharmazie. 2003;58(7):447-74.

  • 5. Malcolm Pimie Inc. Evaluation of the fate and transport of methanol in the environment [Internet] Washington (DC): American Methanol Institute; 1999 [cited 2015 Dec 15] 57 p. Available from:http://www.methanol.org/Environment/Res ources/Environment/MP-Methanol-Fate.aspx.

  • 6. Heward A. PN 06/14 (NAM7): Upgraded MERLIN spies cloud of alcohol spanning 28https://www.ras.org.uk/search/article-archi-ve/973-pn-0614-nam7-upgraded-merlin-spies-cloud-of-alcohol-spanning-288-billion-miles.

  • 7. Monte WC. Aspartame; methanol and the public health. JApplNutr. 1984;36(l):42-58.

  • 8. Turner C Spanel P Smith D. A longitudinal study of methanol in the exhaled breath of 30 healthy volunteers using selected ion flow tube mass spectrometry SIFT-MS. Physiol Meas. 2006;27(7):637-48.

  • 9. Sedived V Mraz M Flek J. Biological monitoring of persons exposed to methanol vapours. Int Arch Occup Environ Health. 1981 ;48(3):257-71.

  • 10. Lesch OM Walter H Wetschka CH Hesselbrock M Hesselbrock V. [Alcohol and tobacco: Medical and sociological aspects of use abuse and addiction] Sofia: Tempora; 2011. Bulgarian. ll.Schmidtke LM Blackman JW Agboola SO. Production technologies for reduced alcoholic wines. J Food Sci. 2012;77( 1 ):R25-41.

  • 12. Radanov S. [Forensic medicine] Sofia: Siela; 2001. Bulgarian.

  • 13. Gilg T. Methanol and congeners as markers of alcohol use and abuse. In: Wurst MF editor. New and upcoming markers of alcohol consumption. Darmstadt: Steinkopfif-Verlag; 2001. p. 35-52.

  • 14. Mechkarska B Hubenova A Stankova E Gesheva M Loukova A. The role of methanol isopropanol and acetone as possible markers for chronic ethanol consumption - preliminary results. In: Programme and abstracts EAPCCT 26th international congress; 2006 Apr 19-22; Prague Czech Republic. Prague: European association of poisons centres and clinical toxicologists p. 165.

  • 15. Monte WC. Methanol: a chemical Trojan horse as the root of the inscrutable U. Med Hypotheses. 2010;74(3):493-6.

  • 16. Kavet R Nauss KM. The toxicity of inhaled methanol vapors. Crit Rev Toxicol. 1990;21( 1):21-50.

  • 17. Andrews LS Clary JJ Terrill JB Bolte HF. Subchronic inhalation toxicity of methanol. J Toxicol Environ Health. 1987;20:117-24.

  • 18. Henzi H. Chronic methanol poisoning with the clinical and pathologic-anatomical features of multiple sclerosis. Med Hypotheses. 1984; 13(l):63-75.

  • 19. Hageman G van der Hoek JAF van Hout MSE van der Laan G Steur EJ de Bruin WI. Parkinsonism pyramidal signs polyneuropathy and cognitive decline after long-term occupational solvent exposure. J Neurol. 1999;246(3): 198-206.

  • 20. Bailey LA Prueitt RL Rhomberg LR. Hypothesis-Based Weight-of-Evidence evaluation of methanol as a human carcinogen. Regul Toxicol Pharmacol. 2012;62(2):278-91.

Search
Journal information
Metrics
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 593 247 20
PDF Downloads 236 126 18