A Case Report of Influence of Free Tyrosine Kinase/Placental Growth Factor (SFLT-1/PLGF) Ratio Test for Preeclampsia on Clinical Decision Making in Screening Positive Women

Polina P. Vasileva 1 , Angel D. Yordanov 2 , Valentina I. Mazneykova 3 , Adelaida L. Ruseva 4 , and Dobromir D. Dimitrov 5
  • 1 Department of Obstetrics and Gynecology, Medical University, Pleven, Bulgaria
  • 2 Department of Oncogynaecology, Georgi Starnski University Hospital, Pleven, Bulgaria
  • 3 Department of Obstetrics and Gynecology, Multiprofile Hospital for Active Treatment “St. Sofia”, Sofia, Bulgaria
  • 4 Department of Clinical Laboratory, Clinical Immunology and Allergology, Medical University, Pleven, Bulgaria
  • 5 Department of Surgical Propaedeutics, Medical University, Pleven, Bulgaria


Preeclampsia (PE) is characterized by hypertension and proteinuria after the 20th gestational week (GW). It is a significant cause of maternal and fetal perinatal morbidity and mortality during pregnancy. There is increasing evidence suggesting that PE is due to an impaired balance between maternal placental angiogenic and antiangiogenic factors that harm maternal vascular endothelium. The study aimed to assess the clinical and financial aspects of introducing into practice the soluble fms-like tyrosine kinase (sFlt-1) to placental growth factor (PlGF) ratio test to improve the management of preeclampsia and adverse pregnancy outcome, intrauterine growth retardation, iatrogenic prematurity, and placental abruption.

We report a case study in which we used the sFlt-1/PlGF ratio in the management of a high-risk pregnancy. Unnecessary hospitalization was avoided, and the patient was managed appropriately.

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