Follow-Up of Neuropsychological Development During the First Postnatal Year in Infants with Neonatal Jaundice

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It is believed that 98% of newborns have elevated serum bilirubin levels, but only about 60% have clinic of jaundice. Severe late neurological effects should not be observed if the serum bilirubin levels are well controlled. To follow-up the motor and mental development during the first year of life in infants suffered from neonatal jaundice. The study includes 92 term babies, divided in four groups: A – without jaundice, B – with jaundice treated by phototherapy in the 1st week , C - intensive jaundice during the first 14 postnatal days , D – intensive prolonged jaundice . Studied indicators: birth weight , gestational age, sex, delivery mode, Apgar score, maternal age and education, domicile, bilirubin serum levels during hospital stay, transcutaneous bilirubin levels ambulatory. Neuro-psychological development was assessed monthly until the 1-year-age.We found that groups were comparable across the all indicators except for residence, with significant difference for groups B and D. There was a statistically significant development delay in the Group D compared to the other three groups in the all studied age periods. All the cases of prolonged jaundice were resolved until the age of 3rd month. According to our data, prolonged jaundice compromises the first-year-psychomotor- development of the infants.

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  • 1. Dennery PA Seidman DS Stevenson DK. Neonatal hyperbilirubinemia. Wood AJJ editor. N Engl J Med. 2001;344(8):581-90.

  • 2. Bhutani VK Stark AR Lazzeroni LC et al. Predischarge screening for severe neonatal hyperbilirubinemia identifies infants who need phototherapy. J Pediatr. 2013;162(3):477-82.

  • 3. Slancheva B Krasteva M Georgieva R Mumdjiev Hr. Neonatologya. Laxbook Plovdiv. 2018; 714-741. Bulgarian.

  • 4. Agrawal V Goyal AK Sharma JN Yadav MD. Different causes of prolonged unconjugated Jaundice in the newborns. International Journal of Contemporary Pediatrics. 2017;4(3):984.

  • 5. Newman TB Liljestrand P Jeremy RJ Ferriero DM Wu YW Hudes ES et al. Outcomes among newborns with total serum bilirubin levels of 25 mg per deciliter or more. N Engl J Med. 2006;354(18):1889-900.

  • 6. Ordinance No. 2 on the organization and verification of preventive examinations in persons from 0 to 18 years and dispensary monitoring of carefully health insured persons of February 4 2003 State Gazette № 4 of January 16 2004. Bulgarian.

  • 7. Olusanya BO Kaplan M Hansen TWR. Neonatal hyperbilirubinaemia: a global perspective. Lancet Glob Health. 2018;2(8):610-20.

  • 8. Wu YW Kuzniewicz MW Wickremasinghe AC Walsh EM Wi S McCulloch CE et al. Risk for cerebral palsy in infants with total serum bilirubin levels at or above the exchange transfusion threshold. JAMA Pediatrics. 2015;169(3):239.

  • 9. Shapiro S Le Pichon JB Riordan SM Watchkoe J. The neurological sequelae of neonatal hyperbilirubinemia: definitions diagnosis and dreatment of the dernicterus spectrum disorders (KSDs). Current Pediatric Reviews. 2017;13.

  • 10. Olds C Oghalai JS. Audiologic impairment associated with bilirubin-induced neurologic damage. Semin Fetal Neonat M. 2015;20(1):42-6.

  • 11. Hokkanen L Launes J Michelsson K. Adult neurobehavioral outcome of hyperbilirubinemia in full term neonates – a 30-year prospective follow-up study. Peer J. 2014;2:e294.

  • 12. Lv M Zhang H Shu Y Chen S Hu Y Zhou M. The neonatal levels of TSB NSE and CK-BB in autism spectrum disorder from Southern China. Transl. Neurosci. 2016;7(1).

  • 13. Kuzniewicz MW Niki H Walsh EM McCulloch CE Newman TB. Hyperbilirubinemia phototherapy and childhood asthma. Pediatrics. 2018;142(4):e20180662.

  • 14. Ramy N Ghany EA Alsharany W Nada A Darwish RK Rabie WA et al. Jaundice phototherapy and DNA damage in full-term neonates. J Perinatol. 2015;36(2):132-6.

  • 15. Yahia S Shabaan AE Gouida M El-Ghanam D Eldegla H El-Bakary A et al. Influence of hyperbilirubinemia and phototherapy on markers of genotoxicity and apoptosis in full- term infants. Eur J Pediatr. 2014;174(4):459-64.

  • 16. Krishna H Changil A Srinivas M Roy TS Jacob TG. Ultrastructural study of rat testis following conventional phototherapy during neonatal period. J Microsc Ultrastruct. 2018;6(4):205-11.

  • 17. Kanmaz HG Okur N Dilli D Yesilyurt A Oguz SS. The effect of phototherapy on sister chromatid exchange with different light density in newborn hyperbilirubinemia. Turk Pediatri Ars. 2018;52(4):202-7.

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