Clinical Aspects of Food Allergy in Infants in Pleven Region, Bulgaria

Vanya M. Nedkova-Milanova 1 , Tsvetelina V. Miteva 1 , Darina N. Hristova 2 , Lyubomira D. Gadjelova 1 , and Magdalena I. Balashkova 1
  • 1 Division of General Medicine, Medical University – Pleven, Bulgaria
  • 2 Department of Hygiene, Medical University - Varna, Bulgaria


Food allergy is an immunoglobulin E-meditated reaction, to which the organism’s immune system reacts to a food allergen, recognizing it as harmful. The study aimed to establish at what age cow’s milk protein allergy is manifested and determine the values of immunoglobulin E (IgE) and hemoglobin(Hb) in children with CMPA in Pleven region, Bulgaria. The study included 94 infants presenting with clinical manifestations of food allergy (age range 0 to 12 months) from Pleven and Pleven region, consulted in 2017 by a pediatrician at the University Hospital Consulting Center in Pleven. Venous blood was collected to determine the IgE and Hb values. Chronic iron-deficiency anemia could be the only clinical manifestation in children with CMPA. Out of all the children with CMPA, 17% had a pronounced anemic syndrome. The rest had normal Hb values. Anemic syndrome could have severe consequences for a growing child. Elevated IgE values were found in 73% of the children tested. CMPA is frequently seen in infants. Early diagnosis of clinical manifestations and diet could prevent severe complications of allergy such as chronic diarrhea, chronic urticaria, and asthma.

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