Open access

Summary

Affective disorders, including depression, are of great social importance and lead to serious everyday life infringement and disability. Affective disorders are one of the main causes of suicide causes. Anxiety disorders represent a variety of psychic disorders that often lead to disability. Anxiety and depression syndromes together are often seen in patients. Vitamin B12 (cobalamin) is the only vitamin containing cobalt. Our aim was to investigate, evaluate and compare depression and increased anxiety and serum Vitamin B12 level in patients with depression, in patients with Vitamin B12 deficiency anemia and healthy controls. We investigated 74 subjects – 38 patients and 36 healthy controls. Serum Vitamin B12 level was measured in all participants. It is assumed that normal ranges of Vitamin B12 level vary. The most recently accepted ones are 200 to 900 pg/ml. In cases of levels below 200 pg/ml, a therapy with vitamin B12 should be applied. On the other hand, the level necessary for normal biochemical processes is higher – 250 pg/ml. In our study, serum Vitamin B12 level in more than 50% of patients with depression/anxiety was below 200 pg/ml, and in more than 60% of these patients it was below 250 pg/ml.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Kaplan HI Sadock BJ. Kaplan. and Sadock‘s synopsis of psychiatry: behavioral sciences clinical psychiatry. 11th ed. London:Wolters Kluwer;2015.

  • 2. Andersan NC Black OW. Introductory textbook of psychiatry. 3rd ed. London: American psychiatric publishing. Inc; 2001.

  • 3. Milanova VK. [Psychiatry – book for medical student and medical specialists].1st ed. Sofia: Medicine and P.T;2013. Bulgarian.

  • 4. Akabaliev V. [Book for medical student]. 3rd ed. Plovdiv: Laks book; 2015. Bulgarian.

  • 5. Boncheva I. [Medical psychology – book for health care specialists]. Varna: Medical University;2012. Bulgarian.

  • 6. Madzhirova N. [Practical Guide of psychiatry for general medicine specialists]. Sofia: Rajkov; 2009. Bulgarian.

  • 7. Stoimenova M. [The suicide – an escape or a decision?] Sofia: Oita-M; 2014. Bulgarian.

  • 8. Todorov V Ljutckanova E Marinova I Lyubomirova D Tzvetkov N. [Internal diseases 2nd part - book for medical students]. 1st ed. Pleven: Medical University; 2012. Bulgarian.

  • 9. Morris AL Thomas AB Francis JK Jerome L Loren RM Richard W. Megavitamin and orthomolecular therapy in psychiatry. Washington: American Psychiatric Association; 1973.

  • 10. Airola P. Hypoglycemia: A Better Approach. Phoenix Ariz.: Health Plus Publishers; 1977.

  • 11. Miller C. Vitamin B12 for depression. Livestrong.com [Internet].c2017 [cited 2017 Sept] [about 1p.] Available from: https://www.livestrong.com/article/463325-vitamin-b12-for-depression/

  • 12. Coppen A Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacol. 2005;19(1):59-65.

  • 13. Methylcobalamininfo Info. Treating depression with vitamin B12. [Internet]. c2015 [cited 2017 Sept22]; [about 1 screen.] Available from: http://www.methylcobalamininfo.com/b12-depression-treatment/

  • 14. Barclay L. Vitamins B6 B12 may protect against depression in older adults. Medscape [Internet] 2010; [cited 2017 Sept 12]; [about 1 p.] Available from: https://www.medscape.com/viewarticle/724456.

Search
Journal information
Metrics
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 941 770 54
PDF Downloads 404 291 34