Fatal aluminium phosphide poisoning

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Abstract

Aluminium phosphide (AlP) is a cheap solid fumigant and a highly toxic pesticide which is commonly used for grain preservation. AlP has currently aroused interest with a rising number of cases in the past four decades due to increased use for agricultural and non-agricultural purposes. Its easy availability in the markets has increased also its misuse for committing suicide. Phosphine inhibits cellular oxygen utilization and can induce lipid peroxidation. Poisoning with AlP has often occurred in attempts to commit suicide, and that more often in adults than in teenagers. This is a case of suicidal consumption of aluminium phosphide by a 32-year-old young medical anesthetist. Toxicological analyses detected aluminium phosphide. We believe that free access of celphos tablets in grain markets should be prohibited by law.

Arora B, Punia RS, Kalra R, Chugh SN, Arora DR. (1995). Histopathological changes in aluminium phosphide poisoning. J Indian Med Assoc 93(10): 380–381.

Jain AK, Nigam M, Garg SD, Dubey BP, Arora A. (2005). Aluminium phosphide poisoning – Autopsy findings. JIAFM 27(1): 35–39.

Bolter C, Chefurka W. (1989). Extra mitochondrial release of hydrogen peroxide from insects and mouse liver mitochondria using respiratory inhibitors--phosphine, nyxothiazol, antimycin and spectral analysis of inhibited cytochromes. Arch Biochem Biophys 278(1): 65–72.

Chefurka W, Kashi KP, Bond EJ. (1976). The effect of phosphine on electron transport in mitochondria. Pest Biochem Physiol 6: 350–362.

Chopra JS, Kalra OP, Malik VS, Sharma R, Chandna A (1986): Aluminium phosphide poisoning: a prospective study of 16 cases in one year. Postgrad Med J 62: 1113–1115.

Chugh SN. (1992), Aluminium phosphide poisoning – present status and management JAPL 40: 401–405.

Chugh SN. (1995). Aluminium phosphide poisoning with special reference on its diagnosis and management. Review article. J Ind Assoc Clin Med 1: 20–22.

Chugh SN, Arora V, Sharma A, Chugh K. (1996). Free radical scavengers and lipid peroxidation in acute aluminium phosphide poisoning. Indian J Med Res 104: 190–193.

Chugh SN, Ram S, Shanna Anjali, Arora BB Saini AS, Malhotra KG. (1988). Adrenocortical involvement in Aluminium phosphide poisoning. Indian J Med Res 90: 289–294.

Chugh SN, Santram, Mehta L. (1991). Adult respiratory distress syndrome (ARDS) following Aluminium phosphide poisoning. J Assoc Physician India 37: 27.

Garry VF, Good PF, Manivel JC, Perl DP. (1993). Investigation of a fatality from non occupational aluminium phosphide exposure: measurement of aluminium in tissue and body fluids as a marker of exposure. J Lab Clin Med 122: 739–747.

Gupta BD, Hapani JH, Shah VN. (2006). Current trend of poisoning in Jamnagar. J Indian Acad Forensic Med 28(3): 90–92.

Kabra SG, Narayanan R. (1988). Aluminium phosphide: worse than Bhopal. Lancet 1(8598): 1333.

Karamjit S, Oberoi SS, Bhullar DS. (2003). Poisoning trends in the Malwa region of Punjab. J Punjab Acad Forensic Med Toxicol 3: 26–29.

Khosla SN, Handa R, Khosla P. (1992). Aluminium phosphide poisoning. Trop Doct 22(4): 155–157.

Khosla SN, Chugh SN, Nityanand, Saini RS. (1986). Systemic involvement in Aluminium phosphide poisoning. JAPL 34(3): 227–230

Mehrpour O, Singh S (2010): Rice tablet poisoning: a major concern in Iranian population. Hum Exp Toxicol 29: 701–702.

Mishra UK, Tripathi AK, Pandey R. (1989). The spectrum of phosphine toxicity in India. JAPL 37: 68.

Nagar KS. (1985). Aluminium phosphide poisoning. J Assoc Physicians India 33(12): 819–820.

Raman R, Dubey M. (1985). The electrocardiographic changes in quick phos poisoning. Ind Heart J 37(3): 193–195.

Ranga GS, Dwivedi S, Agarwal M, Kumar D. (2004): Aluminium phosphide poisoning in a young adult: a suicidal cardiotoxin simulating myocardial ischaemia. J Ind Acad Clin Med 5: 369.

Saraswat PK, Gupta BP, Malhotra VK, Goyal VK. (1985). Prevalence of fatalities due to Aluminium phosphide poisoning in Southern Rajasthan (an epidemiological study). J Forensic Med Toxicol 2: 1–7.

Sepaha GC, Bharani AK, Jain SM, Raman PG. (1985). Actue aluminium phosphide poisoning. J Indian Med Assoc 83(11): 378–9.

Singh D, Dewan I, Pandey AN, Tyagi S. (2003): Spectrum of unnatural fatalities in the Chandigarh zone of north-west India – a 25 year autopsy study from a tertiary care hospital. J Clin Forensic Med 10: 145–152.

Dalbir S, Indarjit D, Vashisht R. (1985). Aluminium phosphide poisoning –autopsy and histopathological findings. JFMT 12(1&2): 16–20.

Singh S, Dilwari JB, Vashisht R, Malhotra HS, Sharma BK. (1985). Aluminium phosphide ingestion. British Medical Journal 40: 110–111.

Siwach SB, Yadav DR, Arora B, Dalal S, Jagdish. (1988). Acute aluminium phosphide poisoning – An epidemiological, clinical and histopathological study. J Assoc Physicians India 36(10): 594–596.

Sudakin DL. (2005). Occupational exposure to aluminium phosphide and phosphine gas? A suspected case report and review of the literature. Hum Exp Toxicol 24: 27–33.

Interdisciplinary Toxicology

The Journal of Institute of Experimental Pharmacology of Slovak Academy of Sciences

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